A5081296091- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Diet, Metabolism, and Disease
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Ubiquitin and proteasome pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Adenosine and Purinergic Signaling
- Protease and Inhibitor Mechanisms
- Erythrocyte Function and Pathophysiology
- Galectins and Cancer Biology
- Cellular transport and secretion
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Calcium signaling and nucleotide metabolism
- Bone and Joint Diseases
- Renal and related cancers
- S100 Proteins and Annexins
- Pulmonary Hypertension Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Tuberculosis Research and Epidemiology
University of Gothenburg
2020-2023
Wallenberg Wood Science Center
2023
MRC Protein Phosphorylation and Ubiquitylation Unit
2016-2022
University of Dundee
2016-2022
Article22 May 2018Open Access Transparent process LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages Anetta Härtlova MRC Protein Phosphorylation and Ubiquitylation Unit, University Dundee, UK Newcastle University, Newcastle-upon-Tyne, Search for more papers by this author Susanne Herbst Host-Pathogen Interactions Tuberculosis Laboratory, The Francis Crick Institute, London, Crick-GSK Biomedical LinkLabs, GlaxoSmithKline Pharmaceuticals R&D,...
Abstract Phagocytosis is a key process in innate immunity and homeostasis. After particle uptake, newly formed phagosomes mature by acquisition of endolysosomal enzymes. Macrophage activation interferon gamma (IFN‐γ) increases microbicidal activity, but delays phagosomal maturation an unknown mechanism. Using quantitative proteomics, we show that proteins harbour high levels typical atypical ubiquitin chain types. Moreover, ubiquitylation vesicle trafficking substantially enhanced upon IFN‐γ...
Resident tissue macrophages are organ-specialized phagocytes responsible for the maintenance and protection of homeostasis. It is well established that diversity reflected by heterogeneity resident macrophage origin phenotype. However, much less known about tissue-specific phagocytic proteolytic functions. Here, using a quantitative proteomics approach, we identify cathepsins as key determinants phagosome maturation in primary peritoneum-, lung-, brain-resident macrophages. The data further...
Abstract Obesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, exact mechanisms remain incompletely understood. Here we demonstrate that macrophage scavenger receptor 1 (MSR1, CD204) expression associated with occurrence hepatic lipid-laden foamy macrophages and correlates degree steatosis steatohepatitis cohort 170 NAFLD patients. Mice lacking Msr1 are protected against high fat-cholesterol diet (HFD)-induced metabolic...
Summary Phagocytosis is a key process in innate immunity and homeostasis. After uptake, newly formed phagosomes mature by acquisition of endo-lysosomal enzymes. Macrophage activation interferon-gamma (IFN-γ) increases microbicidal activity, but delays phagosomal maturation an unknown mechanism. Using quantitative proteomics, we show that proteins harbour high levels typical atypical ubiquitin chain types. Moreover, ubiquitylation vesicle trafficking substantially enhanced upon IFN-γ...
ABSTRACT Resident tissue macrophages (RTMs) are organ-specialized phagocytes responsible for the maintenance and protection of homeostasis. It is well established that diversity reflected by heterogeneity RTMs origin phenotype. However, much less known about tissue-specific phagocytic proteolytic macrophage functions. Here, using quantitative proteomics approach, we identify cathepsins as key determinants phagosome maturation in primary peritoneal, lung brain resident macrophages. The data...
Myofibroblasts, considered main drivers in IPF, gather fibrotic foci where adjacent macrophages secrete mediators affecting their function. Of special interest is PGE<sub>2</sub>, which acutely peaks during early inflammation and reemerges with extended high levels the post-resolution phase. Here, we mimic resolution milieu by chronic dose PGE<sub>2</sub> to study transcriptomic, metabolic phenotypic changes IPF myofibroblasts macrophages. TGF-β1-induced were treated 500 nM global...