A5102900744- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Urinary Tract Infections Management
- Neonatal and fetal brain pathology
- Pancreatic function and diabetes
- Cannabis and Cannabinoid Research
- Pharmacological Effects of Natural Compounds
- Lipid metabolism and biosynthesis
- Antibiotic Resistance in Bacteria
- Neuroscience of respiration and sleep
- Blood Coagulation and Thrombosis Mechanisms
- Metabolism, Diabetes, and Cancer
- Infrared Thermography in Medicine
- Lipid metabolism and disorders
- Fatty Acid Research and Health
- Neonatal Respiratory Health Research
- Thyroid Cancer Diagnosis and Treatment
- Enterobacteriaceae and Cronobacter Research
- Cardiovascular Disease and Adiposity
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
AstraZeneca (Sweden)
2015-2024
University of Gothenburg
2005-2023
Region Västra Götaland
2023
Sahlgrenska University Hospital
2023
Charlottesville Medical Research
2019
Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of advanced chronic disease. The progression NAFLD, including nonalcoholic steatohepatitis (NASH), has strong genetic component, and the most robust contributor patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 encoding 148M protein sequence variant. We hypothesized that suppressing expression PNPLA3 mutant would exert beneficial effect on entire spectrum NAFLD. examined effects liver-targeted...
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty disease, encompasses steatosis and metabolic steatohepatitis (MASH), leading to cirrhosis hepatocellular carcinoma. Preclinical MASLD research is mainly performed in rodents; however, the model that best recapitulates human yet be defined. We conducted a wide-ranging retrospective review (metabolic phenotype, histopathology, transcriptome benchmarked against humans) of murine...
Peroxisome proliferator-activated receptors (PPARs) are key transcription factors that regulate adipose development and function, the conversion of white into brown-like adipocytes. Here we investigated whether PPARα PPARγ activation synergize to induce browning fat.A selection PPAR activators was tested for their ability both mouse human adipocytes in vitro, vivo lean obese mice.All dual PPARα/γ robustly increased uncoupling protein 1 (Ucp1) expression with tesaglitazar leading largest Ucp1...
Abstract Fatty liver disease (FLD) is a growing health issue with burdening unmet clinical needs. FLD has genetic component but, despite the common variants already identified, there still missing heritability component. Using candidate gene approach, we identify locus (rs71519934) at Pleckstrin and Sec7 domain-containing 3 ( PSD3 ) resulting in leucine to threonine substitution position 186 of protein (L186T) that reduces susceptibility entire spectrum individuals risk. downregulation by...
Abstract Objective Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a global health concern with no effective and specific drug treatment available. The rs2642438 minor allele in mitochondrial amidoxime‐reducing component 1 ( MARC1 ) results an aminoacidic substitution (p.Ala165Thr) associates protection against MASLD. However, the mechanisms behind this protective effect are unknown. In study, we examined consequences of on protein stability subcellular localization....
Abstract The receptors mediating the hemodynamic responses to cannabinoids are not clearly defined due multifarious pharmacology of many commonly used cannabinoid ligands. While both CB 1 and TRPV implicated, G protein‐coupled receptor 55 ( GPR 55) may also mediate some effects several atypical present studies attempted unravel underlying in vivo ACEA agonist), O‐1602 AM 251 antagonist), cannabidiol CBD ; antagonist). Agonist antagonist profiles each ligand were determined by ligand‐induced...
The aim of this study was to compare the plasma exposure and tissue accretion docosahexaenoic acid (DHA) in response oral dosing free carboxylic (OM3CA) ethyl ester (OM3EE) forms.Sixteen adult male Wistar rats, fed a low-fat, carbohydrate-rich, standard chow diet, were chronically catheterized gavaged for 5 consecutive days with either OM3CA (n = 9) or OM3EE 7), last day fasted overnight spiked respectively 14C-DHA 14C-DHA-ethyl (14C-DHA-EE) tracers. Appearance 14C-labelled polar neutral...
The global emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli), mainly causing urinary tract infections (UTI), is a major threat to human health. ESBL-E. sequence type (ST) 131 the dominating clone worldwide, especially its subclade C2. Patients developing recurrent UTI (RUTI) due ST131 C2 appear have an increased risk infections. We thus compared whole genome isolates from 14 patients with RUTI those sporadic (SUTI). aimed elucidate if can be associated...
Haemophilia A and B are treated with FVIII FIX replacement therapy. Treatment may be complicated by inhibitory antibodies that require bypass therapy such as FEIBA(®) in which prothrombin (FII) is suggested to the main active component.To evaluate effect of FII on haemophilia recombinant human (rh) (MEDI8111) or plasma-derived (pdhFII) was given single doses anaesthetized mice 3 min before tail transection rhFVIII rhFIX used for comparison. After transection, automatic bleeding registration...
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are effective treatments for improving glucose control and reducing cardiovascular events in patients with T2D. In the present study we examined metabolic effects of chronic treatment SGLT2i dapagliflozin obese insulin resistant Zucker rats. Three different studies were performed aims to assess: 1) liver CoA intermediates, 2) whole-body FA metabolism using a constant infusion 3H-palmitate 3) tissue-specific rates utilization storage...
Increasing brown adipose tissue abundance or activity converting white into adipocytes holds promise for the treatment of type 2 diabetes and obesity. Several PPARγ agonists, including rosiglitazone, have been shown to robustly induce browning (WAT) in vitro but their effects vivo are less pronounced, while PPARα agonists show modest both vivo. In present study, we investigated whether dual agonism would synergistic inducing WAT. We found that all tested PPARα/γ increased uncoupling protein...