A5100704707- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Oral and Maxillofacial Pathology
- Soft tissue tumor case studies
- Pregnancy and preeclampsia studies
- Traditional Chinese Medicine Analysis
- Bone Tumor Diagnosis and Treatments
- Natural product bioactivities and synthesis
- Laser Applications in Dentistry and Medicine
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Histone Deacetylase Inhibitors Research
- Enzyme Structure and Function
- Ginseng Biological Effects and Applications
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Mycobacterium research and diagnosis
- Studies on Chitinases and Chitosanases
- Schizophrenia research and treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Ectopic Pregnancy Diagnosis and Management
- Sarcoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Treatment of Major Depression
- Transcranial Magnetic Stimulation Studies
Zhaoqing University
2018-2025
Southern Medical University
2025
Nanfang Hospital
2025
Shanghai Jiao Tong University
2023-2024
International Peace Maternity & Child Health Hospital
2023-2024
First People's Hospital of Foshan
2023
Shenzhen Institute for Drug Control
2023
Sun Yat-sen University
2021-2022
Third Affiliated Hospital of Sun Yat-sen University
2021-2022
The First People's Hospital of Zhaoqing
2022
Fetal intrauterine distress (FD) during delivery can cause fetal hypoxia, posing significant risks to the fetus, mother, and newborns. While studies highlight role of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in neonatal diseases tumor their specific involvement newborns experiencing (FDNB) is not well understood. Here, we found elevated PMN-MDSC activation, increased glycolysis, enhanced lactate production, upregulated HIF-1α expression blood FDNB neonates compared...
Objective Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with high mortality rates partially due to limited therapeutic options and drug resistance. Arsenic trioxide (ATO), compound clinically proven for acute promyelocytic leukemia (APL), has garnered attention its emerging efficacy in solid tumors, including HCC. However, the molecular mechanisms driving ATO’s antitumor activity HCC remain incompletely understood. In this study, we aimed elucidate...
Salutaxel (3) is a conjugate of docetaxel (7) and muramyl dipeptide (MDP) analogue. Docetaxel has been recognized as highly active chemotherapeutic agent against various cancers. MDP its analogues are powerful potentiators the antitumor actions tumor-necrotizing agents. This article documents discovery compound 3 presents pharmacological proof biological function in tumor-bearing mice. Drug candidate was superior to 7 ability prevent tumor growth metastasis. Compound suppressed...
Background MRI‐based placental analyses have been used to improve fetal growth restriction (FGR) assessment by complementing ultrasound‐based measurements. However, these are still limited time‐consuming manual annotation in MRI data and the lack of mother‐based information. Purpose To develop validate a hybrid model for accurate FGR automatic radiomics on T2‐weighted imaging (T2WI) multifeature fusion. Study Type Retrospective. Population 274 pregnant women (29.5 4.0 years) from two centers...
This work aimed to develop an efficient L-leucine industrial production strain of Corynebacterium glutamicum by using metabolic engineering. A recombinant C. was constructed expressing a feedback-resistant leuA-encoded 2-isopropylmalate synthase (IPMS) that carries three amino acid exchanges (R529H, G532D and L535V) from the mutant ML1-9 which obtained screening for structural analogues. In order improve expression IPMS, strong promoter (tac promoter) used ensure rate-limiting enzyme....
Background Glioblastoma multiforme (GBM) is the most lethal brain cancer in adults, characterized by rapid growth, extensive invasiveness, and poor prognosis, there still a lack of effective treatments. Here, we aimed to explore role triptolide (TPL), purified from Tripterygium wilfordii Hook F, on glioblastoma cell apoptosis, proliferation, migration invasion, as well potential underlying mechanisms. Methods The publicly available clinical data Brain Lower Grade Glioma (LGG) Cancer Genome...
Recent studies have illuminated that blocking Ca2+ influx into effector cells is an attractive therapeutic strategy for lung injury. We hypothesize T-type calcium channel may be a potential target acute injury (ALI). In this study, the pharmacological activity of mibefradil (a classical inhibitor) was assessed in mouse model lipopolysaccharide- (LPS-) induced ALI. LPS challenged mice, (20 and 40 mg/kg) dramatically decreased total cell number, as well productions TNF-α IL-6 bronchoalveolar...
Aims. To explore the effects of Biejiaxiaozheng pills on carbon tetrachloride-induced hepatic fibrosis in rats through NF-κB/Nrf2 pathway and to possible antifibrotic mechanisms drug. Material Method. A rat model was established via CCl4 induction. Liver function antioxidant indices were detected using commercial kits. Hematoxylin-eosin Masson staining used detect pathological changes tissues. ELISA measure plasma TNF-α, IL-β, IL-6 levels. RT-PCR levels Changes p65, P-p65, Nrf2, HO-1 protein...