A5086674033- Gut microbiota and health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Liver Disease Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Drug-Induced Hepatotoxicity and Protection
- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Pharmacological Effects of Natural Compounds
- Urinary Tract Infections Management
- Helicobacter pylori-related gastroenterology studies
- Clinical Nutrition and Gastroenterology
- Microbial Natural Products and Biosynthesis
- Microbial Metabolites in Food Biotechnology
- Microbial Metabolism and Applications
- Microscopic Colitis
- Tryptophan and brain disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Alcohol Consumption and Health Effects
- RNA and protein synthesis mechanisms
- Machine Learning in Bioinformatics
- Amino Acid Enzymes and Metabolism
- Pelvic floor disorders treatments
Tongde Hospital of Zhejiang Province
2025
First Affiliated Hospital Zhejiang University
2014-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2015-2024
Zhejiang University
2015-2024
National Clinical Research Center for Digestive Diseases
2022-2024
National Center for Infectious Diseases
2021-2024
National Clinical Research
2021-2024
Zhengzhou University
2024
Nantong University
2022
South China Institute of Collaborative Innovation
2019
Trillions of microbes have evolved with and continue to live on within human beings. A variety environmental factors can affect intestinal microbial imbalance, which has a close relationship health disease. Here, we focus the interactions between microbiota host in order provide an overview role basic biological processes development progression major diseases such as infectious diseases, liver gastrointestinal cancers, metabolic respiratory mental or psychological autoimmune diseases. We...
Inflammatory bowel diseases (IBDs) develop as a result of complex interactions among genes, innate immunity and environmental factors, which are related to the gut microbiota. Multiple clinical animal data have shown that Akkermansia muciniphila is associated with healthy mucosa. However, its precise role in colitis currently unknown. Our study aimed determine protective effects underlying mechanisms dextran sulfate sodium (DSS)-induced mouse model. Twenty-four C57BL/6 male mice were...
Accumulating evidence indicates that gut microbiota participates in the pathogenesis and progression of liver diseases. The severity immune-mediated injury is associated with different microbial communities. Akkermansia muciniphila can regulate immunologic metabolic functions. However, little known about its effects on structure function. This study investigated effect A. potential underlying mechanisms. Twenty-two C57BL/6 mice were assigned to three groups (N = 7-8 per group) continuously...
We selected 42 early-stage primary biliary cirrhosis (PBC) patients and 30 healthy controls (HC). Metagenomic sequencing of the 16S rRNA gene was used to characterize fecal microbiome. UPLC-MS/MS assaying small molecules metabolomes serum, urine feces. Liquid chip serum cytokines immune profiles. The gut PBC were depleted some potentially beneficial bacteria, such as Acidobacteria, Lachnobacterium sp., Bacteroides eggerthii Ruminococcus bromii, but enriched in bacterial taxa containing...
Butyrate exerts protective effects against non-alcoholic steatohepatitis (NASH), but the underlying mechanisms are unclear. We aimed to investigate role of butyrate-induced gut microbiota and metabolism in NASH development. Sixty-five C57BL/6J mice were divided into four groups (n = 15-17 per group) fed either a methionine-choline-sufficient (MCS) diet or methionine-choline-deficient (MCD) with without sodium butyrate (SoB; 0.6 g/kg body weight) supplementation for 6 weeks. Liver injury,...
Our work revealed that A. muciniphila attenuated APAP-induced liver injury by alleviating oxidative stress and inflammation in the liver, its hepatoprotective effect was accompanied activation of PI3K/Akt pathway mediated regulation composition metabolic function intestinal microbiota. This finding suggested microbial community is a non-negligible impact on drug metabolism probiotic administration could be potential therapy for drug-induced injury.
The relationship between gut microbes and COVID-19 or H1N1 infections is not fully understood. Here, we compared the mycobiota of 67 patients, 35 H1N1-infected patients 48 healthy controls (HCs) using internal transcribed spacer (ITS) 3-ITS4 sequencing analysed their associations with clinical features bacterial microbiota. Compared to HCs, fungal burden was higher. Fungal dysbiosis in both mainly characterized by depletion fungi such as Aspergillus Penicillium, but several fungi, including...
Inflammatory bowel disease (IBD) is an idiopathic inflammatory with a high incidence. Multiple factors including dietary composition contribute to its occurrence. Recently, ketogenic diet which consists of proportion fat and low carbohydrates has gained great popularity. Our study aimed explore the effect on IBD potential mechanisms. C57BL/6 mice were given or control for month was induced by 2% DSS in drinking water last week. Gut histology, cytokines chemokines, gut microbiota metabolism...
Gut microbiota are closely related to lipopolysaccharide (LPS)-induced acute lung injury (ALI). Akkermansia muciniphila (A. muciniphila) maintains the intestinal barrier function and regulates balance of reduced glutathione/oxidized glutathione. However, it may be useful as a treatment strategy for LPS-induced injury. Our study aimed explore whether A. could improve by affecting gut microbiota. The administration effectively attenuated tissue damage significantly decreased oxidative stress...
Acetaminophen (APAP) overdose is the most common driver of drug-induced liver injury (DILI) worldwide, and gut microbiome plays a crucial role in this process. In study, we estimated effect Bifidobacterium longum R0175 on APAP-induced mice discovered that B. alleviated by diminishing inflammation, reducing oxidative stress levels, inhibiting hepatocyte death improving dysbiosis. Further studies revealed antioxidative effects were primarily due to activation Nrf2 pathway, which was supported...
Alterations in the gut microbiome have been reported liver cirrhosis, and probiotic interventions are considered a potential treatment strategy. This study aimed to evaluate effects mechanisms of Lactobacillus salivarius LI01, Pediococcus pentosaceus LI05, rhamnosus GG, Clostridium butyricum MIYAIRI Bacillus licheniformis Zhengchangsheng on CCl4-induced cirrhotic rats. Only administration LI01 or LI05 prevented fibrosis down-regulated hepatic expression profibrogenic genes. Serum endotoxins,...
The gut microbiota is altered in liver diseases, and several probiotics have been shown to reduce the degree of damage. We hypothesized that oral administration specific Bifidobacterium strains isolated from healthy guts could attenuate injury. Five were tested this study. Acute injury was induced by D-galactosamine after pretreating Sprague-Dawley rats with strains, function, ileum histology, plasma cytokines, bacterial translocation microbiome assessed. Two pseudocatenulatum LI09...
The gut microbiota is considered a key factor in pathogenesis and progression of inflammatory bowel disease (IBD). bacterium Pediococcus pentosaceus LI05 alleviated host inflammation by maintaining the epithelial integrity, modulating immunity, metabolism, but its effect on IBD remains unclear. present study aimed to investigate role mechanisms P. LI05. Mice were administered or phosphate-buffered saline once daily oral gavage for 14 days, colitis was induced providing mice 2% DSS-containing...
Background Intestinal dysbiosis has been shown to be associated with the pathogenesis of alcoholic liver disease (ALD), which includes changes in microbiota composition and bacterial overgrowth, but an effective microbe-based therapy is lacking. Pediococcus pentosaceus (P. pentosaceus) CGMCC 7049 a newly isolated strain probiotic that resistant ethanol bile salts. However, further studies are needed determine whether P. exerts protective effect on ALD elucidate potential mechanism. Aim To...
Summary Millions of people die from liver diseases annually, and failure is one the three major outcomes disease. The gut microbiota plays a crucial role in diseases. This study aimed to explore effects Lactobacillus casei strain Shirota (LcS), probiotics used widely around world, on acute injury (ALI), as well underlying mechanism. Sprague Dawley rats were intragastrically administered LcS suspensions or placebo once daily for 7 days before induction ALI by intraperitoneal injection...
Intestinal flora provides an important contribution to the development of pulmonary tuberculosis (PTB). We performed a cross-sectional study in 52 healthy controls (HCs) and 83 patients with untreated active PTB assess differences their microbiomic metabolic profiles faeces via V3-V4 16S rRNA gene sequencing gas chromatography-mass spectrometry. Patients had considerable reductions phylogenetic alpha diversity production short-chain fatty acids, dysbiosis intestinal alterations faecal...
Clostridioides difficile is a common cause of nosocomial infection. Antibiotic-induced dysbiosis in the intestinal microbiota core C. infection (CDI). Akkermansia muciniphila plays an active role maintaining gastrointestinal balance and might offer protective effects on CDI as probiotics. Here, we investigated mechanisms A. CDI. C57BL/6 mice (n = 29) were administered Muc T (3 × 109 CFUs, 0.2 mL) or phosphate-buffered saline (PBS) by oral gavage for 2 weeks. Mice pretreated with antibiotic...
// Fengping Liu 1,4,* , Zongxin Ling 2,3,* Yonghong Xiao Longxian Lv 2,3 Qing Yang 3 Baohong Wang Haifeng Lu Li Zheng 1 Ping Jiang Wei 1,** and Lanjuan 2,3,** Department of Urology, The First Affiliated Hospital, School Medicine, Zhejiang University, Hangzhou, Zhejiang, China 2 State Key Laboratory for Diagnosis Treatment Infectious Diseases, Collaborative Innovation Center 4 Yancheng Medical College, Yancheng, Jiangsu, * These authors have contributed equally to this work ** also...