A5053615429- Gut microbiota and health
- Probiotics and Fermented Foods
- Proteins in Food Systems
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Microbial Metabolites in Food Biotechnology
- Microencapsulation and Drying Processes
- Polysaccharides and Plant Cell Walls
- Infant Health and Development
- Helicobacter pylori-related gastroenterology studies
- Bioactive Compounds in Plants
- Biochemical Analysis and Sensing Techniques
- Nanoparticles: synthesis and applications
- Sirtuins and Resveratrol in Medicine
- Infant Nutrition and Health
- Nanoparticle-Based Drug Delivery
- Food Chemistry and Fat Analysis
- Polysaccharides Composition and Applications
- Ginkgo biloba and Cashew Applications
- Lipid Membrane Structure and Behavior
- Digestive system and related health
- Food composition and properties
- Phytochemicals and Antioxidant Activities
- Fatty Acid Research and Health
- Advanced Drug Delivery Systems
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2016-2025
Zhejiang University
2016-2025
National Clinical Research Center for Digestive Diseases
2020-2024
First Affiliated Hospital Zhejiang University
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
University of Massachusetts Amherst
2013-2021
Center for Innovation
2021
National Clinical Research
2021
Hokkaido University
2011
Trillions of microbes have evolved with and continue to live on within human beings. A variety environmental factors can affect intestinal microbial imbalance, which has a close relationship health disease. Here, we focus the interactions between microbiota host in order provide an overview role basic biological processes development progression major diseases such as infectious diseases, liver gastrointestinal cancers, metabolic respiratory mental or psychological autoimmune diseases. We...
Gastrointestinal disease is characterized by gastrointestinal dysfunction with dysbiosis of the microbiome. Probiotics may act as biological agents in treating diseases through modifying gut microbiota. However, several challenges, including safety, stress resistance, postcolonization quantification, and evaluation models, hinder application probiotics diseases. This review introduces emerging methods for delivering well available materials. Furthermore, we elucidated bacteriocins their role...
Inorganic nanomaterials have been increasingly utilized in many consumer products, which has led to concerns about their potential toxicity. At present, there is limited knowledge the gastrointestinal fate and cytotoxicity of ingested inorganic nanoparticles. This study determined influence particle size concentration gold nanoparticles (AuNPs) on absorption, accumulation, model intestinal epithelial cells. As mean diameter AuNPs decreased (from 100 50 15 nm), rate absorption by epithelium...
Abstract The low viability during gastrointestinal transit and poor mucoadhesion considerably limits the effectiveness of Ligilactobacillus salivarius Li01 (Li01) in regulating gut microbiota alleviating inflammatory bowel disease (IBD). In this study, a delivery system was designed through layer-by-layer (LbL) encapsulating single Li01cell with chitosan alginate. layers were strengthened by cross-linking to form firm mucoadhesive shell (~10 nm thickness) covering bacterial cell. LbL...
Currently approved therapeutical strategies for inflammatory bowel diseases (IBD) suffer from variable efficacy and association with risk of serious side effects. Therefore, efforts have been made in searching alternative therapeutics utilizing gut microbiota manipulation. In this study, we show that the probiotic strain Ligilactobacillus salivarius Li01 (Li01) phytochemical prebiotic resveratrol (RSV) synergistic effect ameliorating colitis mice. Oral coadministration (109 CFU/d) RSV (1.5...
The ability of casein phosphopeptides (CPPs) to bind and transport minerals has been previously studied. However, the single bioactive peptides responsible for effects CPPs have not identified. This study was purify calcium-binding from determine their on calcium magnesium uptake by Caco-2 cell monolayers. Five monomer designated P1 P5 were isolated amino acid sequences determined using LC-MS/MS. Compared with CPP-free control, all five monomeric exhibited significant enhancing (P < 0.05)....
The presence of exopolysaccharides (EPS), a type biomacromolecules, on the surface probiotics play an important role in mucoadhesion, and it can be severely influenced by environments during gastrointestinal transit. In this study, impact factors properties two (Lactobacillus rhamnosus GG Pediococcus pentosaceus LI05) was investigated. Probiotic suspensions had relatively high viscosities exhibited pronounced shear-thinning behavior due to EPS. ζ-potential both low not believed mucoadhesion....
Although Ligilactobacillus salivarius Li01 (Li01) has shown much promise in preventing multiple gastrointestinal diseases, the potential of probiotic alleviating constipation and related mechanisms remain unclear. In this study, effects were evaluated a loperamide-induced mouse model. The results demonstrated that intervention can relieve symptoms by improving water content, quantity, morphology feces act as an intestinal barrier structure protector. Furthermore, modulate gut motility...
Non-alcoholic fatty liver disease (NAFLD), which has a global prevalence of 20%–33%, become the main cause chronic disease. Except for lifestyle medication, no definitive medical treatment been established so far, making it urgent to find effective strategies NAFLD. With identification significant role played by gut microbiota in pathogenesis NAFLD, studies on probiotics prevention and NAFLD are increasing number. Bacteria from Bifidobacterium Lactobacillus genera constitute most widely used...
Resveratrol (RSV) has been confirmed to confer multiple health benefits, and the majority of RSV tends be metabolized in gut microbiota after oral administration. In this study, metabolism was investigated by using mouse models with distinct compositions: germ-free mice colonized probiotics, conventional mouse, DSS-induced colitis models. The results demonstrated that feces, metabolites RSV, including resveratrol sulfate (RES-sulfate), glucuronide (RES-glucuronide), dihydroresveratrol,...
Encapsulated Li05 within a gastro-responsive microgel controlled release in intestine and enhanced its efficacy against CDI.
Antibiotics are the first line of treatment for infectious diseases. However, their overuse can increase spread drug-resistant bacteria. The present study analyzed impact different types antibiotics on gut microbiome and cytokines level mice.A total five groups 8-week-old male BALB/c mice (n = 35) were treated with piperacillin-tazobactam (TZP), ceftriaxone (CRO), tigecycline (TGC), levofloxacin (LEV) or normal saline (Ctrl), respectively, up to 4 weeks. Fecal samples by bacterial 16S rRNA...
Numerous studies have demonstrated that the gut microbiota plays a vital role in human health and disease development. Although number of on host-microbiota interactions increased recent years, underlying pathogenesis dysbiosis-related diseases are still largely unknown. Germ-free (GF) rodent models, with animals housed sterile isolators completely free microbiota, useful tools to advance our understanding relationship vivo. protocols concerning establishment maintenance GF mouse models...