Aims To validate the perfusion, extent, depth, infection and sensation (PEDIS) classification system to make clinical practice easier, we created a score compared this with two previously published common systems. Methods A retrospective cohort study was conducted on patients diabetic foot ulcer (DFU) attending our hospital (n=364) from May 2007 September 2013. Participants' characteristics all variables composing PEDIS were assessed. Results During median follow-up of 25 months (range...

Ferredoxin 1 (FDX1) functions by transferring electrons from NADPH to mitochondrial cytochrome P450 via the ferredoxin reductase and is key regulator in copper-dependent cell death. Although mounting evidence supports a vital role for FDX1 tumorigenesis of some cancers, no pan-cancer analysis has been reported. Therefore, we aimed explore prognostic value investigate its potential immune function. Based on data The Cancer Genome Atlas, Cell Line Encyclopedia, Genotype Tissue-Expression,...

Macrophages play a crucial role in shaping the immune state within tumor microenvironment (TME) and are often influenced by tumors to hinder antitumor immunity. However, underlying mechanisms still elusive. Here, we observed abnormal expression of complement 5a receptor (C5aR) human ovarian cancer (OC), identified high levels C5aR on tumor-associated macrophages (TAMs), which led polarization TAMs toward an immunosuppressive phenotype. knockout or inhibitor treatment restored TAM response...

Abstract Geniposidic acid (GPA) is a bioactive compound isolated from Gardenia jasminoides Ellis ( Rubiaceae ) that has long been used to treat arthritis, jaundice, and hypertension. However, the therapeutic effects of GPA against colitis remain underexplored. This study aimed investigate effect on remission underlying mechanisms. A DSS‐induced mouse model was evaluate influence modulation gut microbiota intestinal epithelial barrier function. Our results indicated improved colitis,...

The acidic microenvironment (AME), like hypoxia, inflammation, or immunoreaction, is a hallmark of the tumor (TME). This work aimed to develop prediction signature dependent on AME-associated lncRNAs in order predict prognosis LC individuals.We downloaded RNA-seq information and corresponding clinical predictive data from Cancer Genome Atlas (TCGA) dataset conducted univariate multivariate Cox regression analyses identify for construction Kaplan-Meier technique was utilized determine overall...

Using preoperative hemoglobin, albumin, lymphocyte, and platelet (HALP) scores, a cutoff value of HALP in endometrial cancer was identified, the significance prognosis evaluated to guide management patients.This study included 626 patients with who underwent surgery at First Affiliated Hospital Chongqing Medical University between June 2015 2020. A Cox regression model used analyze correlation recurrence death, receiver operating characteristic curve determine optimal for predicting lymph...

The purpose of this study was to find a cut-off value the immunohistochemical parameter Ki67 for stage I-II endometrial cancer.The clinicopathological data 318 patients with stages cancer who received primary surgical treatment were retrospectively analyzed. A predicting recurrence determined by using receiver operating characteristic curve and Youden index. Cox regression performed screen factors associated cancer. Based on Ki67, divided into two groups, differences parameters between...

Lymph node metastasis (LNM) is a critical unfavorable prognostic factor in endometrial cancer (EC). At present, models involving molecular indicators that accurately predict LNM are still uncommon. We addressed this gap by developing nomograms to individualize the risk of EC and identify low-risk group for LNM.In all, 776 patients who underwent comprehensive surgical staging with pelvic lymphadenectomy at First Affiliated Hospital Chongqing Medical University were divided into training...

The purpose of this study was to evaluate the prognostic value hemoglobin, albumin, lymphocyte, and platelet (HALP) score in patients with operable cervical cancer, on basis, combined classical clinicopathological parameters predict recurrence patients. A total 1580 stage IA-IIA cancer were randomly divided into training cohort (n=1054) validation (n=526) according predefined ratio 2:1. In cohort, receiver operating characteristic (ROC) curve Youden index used determine optimal threshold...

SLC2A3 is an important member of the glucose transporter superfamily. It has been recently suggested that upregulation associated with poor survival and acts as a prognostic marker in variety tumors. Unfortunately, role head neck squamous cell carcinoma (HNSC) less known. In present study, we analyzed expression HNSC its correlation prognosis using TCGA GEO databases. The results showed mRNA was higher compared adjacent normal tissues, which validated our 9 pairs specimens. Moreover, high...

Controversy exists regarding pathological factors affecting the prognosis of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV-HCC). Their postoperative clinical behaviors and exact HBV Deoxyribonucleic Acid (DNA) thresholds that distinguish good poor prognoses are unknown. This study aimed to compare clinicopathological, pre- overall recurrence-free survival (RFS) between HBV-HCC nonhepatitis C HCC (NBC-HCC) determine optimal prognostic DNA threshold. Data from 1440...

As an intravenous anesthetic, propofol has been exhibited to provide excellent clinical analgesia. Whether amelioration property for NP and neuroinflammation remains unexplored. The present study was arranged probe the role of in mitigation rats underlying mechanisms.Rats were randomly classified into following groups: Model, Sham, Control, Propofol, GW9662, Saline groups. radiant heat stimulation used measure paw withdrawal latency (PWL), mechanical employed detect threshold (PWT)....

Abstract Radiation-induced heart damage is a serious side effect caused by radiotherapy, especially during the treatment of cancer near chest. Trimetazidine effective at reducing inflammation in heart, but how it affects radiation-induced cardiac fibrosis (RICF) unknown. To investigate potential and molecular mechanism, we designed this project with C57BL6 male mouse model supposing trimetazidine could inhibit RICF mice. During experiment, mice were randomly divided into six groups including...

Cuproptosis represents a novel copper-dependent regulated cell death, distinct from other known death processes. In this report, comprehensive analysis of cuproptosis in hepatocellular carcinoma (HCC) was conducted using multi-omics including genomics, bulk RNA-seq, single RNA-seq and proteomics. ATP7A, PDHA1 DLST comprised the top 3 mutation genes The Cancer Genome Atlas (TCGA)-LIHC; 9 cuproptosis-related showed significant, independent prognostic values. Cuproptosis-related hepatocytes...

Histopathological work in clinical labs often relies on immunostaining of proteins, which can be time-consuming and costly. Multiplexed spatial proteomics imaging increase interpretive power, but current methods cannot cost-effectively sample the entire proteomic retinue important to diagnostic medicine or drug development. To address this challenge, we developed a conditional generative adversarial network (cGAN) that performs image-to-image (i2i) synthesis generate accurate biomarker...

Surgery is the best approach to treat endometrial cancer (EC); however, there currently a deficiency in effective scoring systems for predicting EC recurrence post-surgical resection. This study aims develop clinicopathological-inflammatory parameters-based nomogram accurately predict postoperative recurrence-free survival (RFS) rate of patients. A training set containing 1068 patients and an independent validation consisting 537 were employed this retrospective study. The prognostic factors...

The mathematical theories involved in public key cryptography generally include factors decomposition problem of large numbers and discrete logarithm finite field. In current cryptography, problems based on are commonly used, for example, RSA cryptography. With the development computer hardware high-performance computing technology, has encountered some difficulties. situations, elliptic curve appears, whose is short, network bandwidth little ability to resist attack strong. article analyses...

Abstract Background and Objectives We aimed to explore the capacity of combined ratio biomarkers predict recurrence Stage I–III endometrial cancer (EC). Methods A total 473 patients were enrolled after screening. The cut‐off value was calculated by receiver operating characteristic curve (ROC). univariate multivariate Cox regression analysis used assess correlation between EC. differences clinicopathological parameters two groups divided based on threshold compared. Result ROC showed that...

Background The purpose of this study was to establish a nomogram combining classical parameters and immunohistochemical markers predict the recurrence patients with stage I-II endometrial cancer (EC). Methods 419 who received primary surgical treatment at First Affiliated Hospital Chongqing Medical University were involved in as training cohort. Univariate multivariate Cox regression analysis screening prognostic factors performed cohort develop model, which further validated 248 (validation...

Objective:The purpose of this study was to investigate the prognostic value inflammation-immunity-nutrition score (IINS) in patients with stage I-III endometrial cancer (EC) and establish a nomogram model predict recurrence EC by combining IINS traditional classical predictors.Methods: Seven hundred seventy-five who underwent initial surgical treatment at First Affiliated Hospital Chongqing Medical University were included as training cohort.In cohort, (0-3) constructed based on preoperative...