A5089161929- Microbial infections and disease research
- Aquaculture disease management and microbiota
- Bacteriophages and microbial interactions
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- RNA and protein synthesis mechanisms
- Mycobacterium research and diagnosis
- Immune cells in cancer
- Veterinary medicine and infectious diseases
- Streptococcal Infections and Treatments
- IL-33, ST2, and ILC Pathways
- Virus-based gene therapy research
- Infective Endocarditis Diagnosis and Management
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- Myxozoan Parasites in Aquatic Species
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Caveolin-1 and cellular processes
- Bacillus and Francisella bacterial research
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Molecular Biology Techniques and Applications
Jilin University
2015-2025
Jilin Medical University
2020
ABSTRACT Porcine contagious pleuropneumonia caused by Actinobacillus pleuropneumoniae (APP) is a fatal respiratory disease that threatens the worldwide farming industry’s health. The immune responses of extrapulmonary tissues play an important role in developing porcine pleuropneumonia; however, induced APP are rarely uncovered. Here, we used high-dimensional mass cytometry to investigate cell response spleen and peripheral blood during infection mice. We found triggered was highly...
Members of the Trimeric Autotransporter Adhesin (TAA) family play a crucial role in adhesion Gram-negative pathogens to host cells, but immunopathogenesis TAAs remains unknown. Our previous studies demonstrated that Adh from Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is required for full bacterial pathogenicity. Alveolar macrophages are first line defense against respiratory infections. This study compared interactions between porcine alveolar (PAMs) and wild-type A. (5b WT) or an...
Streptococcus suis serotype 2 (SS2), an important zoonotic pathogen that causes septicemia, arthritis, and irreversible meningitis in pigs humans, can be transmitted to humans from pigs. S. huge economic losses the swine industry poses a serious threat public health. Previously, we found brain tissues of mice with SS2-induced showed disrupted structural integrity significantly enhanced polymorphonuclear neutrophil (PMN) infiltration. We SS2-infected had increased ribosomal protein SA...
Abstract Due to the increase in bacterial resistance, improving anti-infectious immunity of host is rapidly becoming a new strategy for prevention and treatment pneumonia. However, specific lung immune responses key cell subsets involved infection are obscure. Actinobacillus pleuropneumoniae (APP) can cause porcine pleuropneumonia, highly contagious respiratory disease that has caused severe economic losses swine industry. Here, using high-dimensional mass cytometry, major repertoire lungs...
Abstract Actinobacillus pleuropneumoniae ( A. pleuropneumoniae/APP ) is the pathogen that causes porcine contagious pleuropneumonia. divided into 18 serovars, and cross protection efficacy of epitopes debatable, which has resulted in slow development a vaccine. Consequently, epitope-based vaccines conferring have rarely been reported. In this study, B cell head domain trimeric autotransporter adhesin were predicted, 6 selected. Then, predicted (Ba1, Bb5, C1, PH1 PH2) connected by linkers to...
Porcine pleuropneumonia is a common infectious disease of pigs caused by Actinobacillus pleuropneumoniae Interferon gamma (IFN-γ) expression increases in the lung after A. infection, but role IFN-γ during infection still obscure. In this study, an IFN-γ-/- mouse model was established, and bacterial load, levels inflammatory cytokines, types neutrophils lungs were studied at different times post-A. infection. We found that wild-type (WT) mice more susceptible to than mice. At 6 h...
Porcine pleuropneumonia caused by Actinobacillus pleuropneumoniae (APP) is a swine respiratory disease with an important impact around the world either as single infection or part of porcine complex. The data interaction between hosts and pathogens has becoming more crucial for exploration mechanism. However, up to now, comparatively little information available on systemic dynamic changes that occur in pig serum response APP infection. This study used iTRAQ identify differentially expressed...
Porcine infectious pleuropneumonia is characterized by a high-rate of carriage and mixed infection with other pathogens. The host immune response induced Actinobacillus pleuropneumoniae (APP) the basis for elucidating pathogenesis controlling disease. However, there currently no comprehensive dynamic data characterising response. In this study, piglets were infected APP differentially expressed proteins bronchoalveolar lavage fluid (BALF) peripheral serum identified iTRAQ-LC-MS/MS, genes...
Abstract Actinobacillus pleuropneumoniae ( A. pleuropneumoniae/APP ) is the pathogen that causes porcine contagious pleuropneumonia. divided into 18 serovars, and cross protection efficacy of epitopes debatable, which has resulted in slow development a vaccine. Consequently, epitope-based vaccines conferring have rarely been reported. In this study, B cell head domain trimeric autotransporter adhesin were predicted, 6 selected. Then, predicted (Ba1, Bb5, C1, PH1 PH2) connected by linkers to...