A5027327587- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Glioma Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Circular RNAs in diseases
- Developmental Biology and Gene Regulation
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Neurobiology and Insect Physiology Research
- Adipose Tissue and Metabolism
- Cancer-related Molecular Pathways
- Nuclear Receptors and Signaling
- Signaling Pathways in Disease
- Autophagy in Disease and Therapy
The University of Texas Southwestern Medical Center
2012-2025
University of Washington
2024
Southwestern Medical Center
2018-2023
Jinan University
2023
KU Leuven
2013
Rice University
2013
Lee College
2013
Baylor College of Medicine
2013
University of Houston
2013
DNA damage-activated nuclease identified Cells that experience stresses and accumulate excessive damage to undergo cell death mediated by a nuclear enzyme known as PARP-1. During this process, apoptosis-inducing factor (AIF) translocates the nucleus activates one or more nucleases cleave DNA. Wang et al. found macrophage migration inhibitory (MIF) is an AIF-associated endonuclease contributes PARP-1-induced fragmentation (see Perspective Jonas). In mouse neurons in culture, loss of MIF...
Hypoxia induces a vast array of long noncoding RNAs (lncRNA) in breast cancer cells, but their biological functions remain largely unknown. Here, we identified hitherto uncharacterized hypoxia-induced lncRNA RAB11B-AS1 cells. is natural upregulated human and its expression induced by hypoxia-inducible factor 2 (HIF2), not HIF1, response to hypoxia. enhanced the angiogenic factors including VEGFA ANGPTL4 hypoxic cells increasing recruitment RNA polymerase II. In line with increased factors,...
Breast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and plasticity. However, the regulatory mechanism of in BCSCs remains unclear. We recently found that histone reader ZMYND8 was upregulated BCSCs. Here, we showed reduced ROS iron inhibit ferroptosis aldehyde dehydrogenase–high (ALDHhi) BCSCs, leading BCSC expansion tumor initiation mice. The underlying involved a two-fold posttranslational regulation nuclear factor erythroid 2–related 2 (NRF2). increased...
Altered epigenetic reprogramming contributes to breast cancer progression and metastasis. How the reader mediates remains poorly understood. Here, we showed that zinc finger MYND-type containing 8 (ZMYND8) is induced by HIF-1 HIF-2 in cells also upregulated human tumors, correlated with poor survival of patients cancer. Genetic deletion ZMYND8 decreases cell colony formation, migration, invasion vitro, inhibits tumor growth metastasis lungs mice. The ZMYND8's oncogenic effect requires HIF-2....
Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator in response to hypoxia and its activity crucial for cancer cell mobility. Here we present evidence novel epigenetic mechanism that regulates HIF-1 HIF-1-dependent migration of glioblastoma cells. The lysine methyltransferases G9a GLP directly bound the α subunit (HIF-1α) catalyzed mono- di-methylation HIF-1α at (K) 674 vitro vivo. K674 methylation suppressed expression downstream target genes PTGS1, NDNF, SLC6A3,...
Abstract Branched-chain amino acid transaminase 1 (BCAT1) is upregulated selectively in human isocitrate dehydrogenase (IDH) wildtype (WT) but not mutant glioblastoma multiforme (GBM) and promotes IDHWT GBM growth. Through a metabolic synthetic lethal screen, we report here that α-ketoglutarate (AKG) kills cells when BCAT1 protein lost, which reversed by reexpression of or supplementation with branched-chain α-ketoacids (BCKA), downstream products BCAT1. In patient-derived tumors vitro vivo,...
Genetic mutations in apoptosis-inducing factor (AIF) have a strong association with mitochondrial disorders; however, little is known about the aberrant splicing variants affected patients and how these contribute to dysfunction brain development defects. We identified pathologic AIF3/AIF3-like postmortem tissues of pediatric individuals disorders. Mutations AIFM1 exon-2/3 increase risks. AIF3-splicing disrupts complexes, membrane potential, respiration, causing Mechanistically, AIF...
Recruitment of RNA polymerase II to hypoxia-inducible factor (HIF) target genes under normoxia is a prerequisite for HIF-mediated transactivation. However, the underlying mechanism this recruitment remains unknown. Here we report that chromodomain helicase DNA-binding protein 4 (CHD4) physically interacts with α and β subunits HIF1 HIF2 enhances HIF-driven transcriptional programs promote breast cancer progression. Loss HIF1/2α abolished CHD4-mediated tumor growth in mice. In cells normoxia,...
Abstract How cancer cells cope with high levels of replication stress during rapid proliferation is currently unclear. Here, we show that macrophage migration inhibitory factor (MIF) a 3’ flap nuclease translocates to the nucleus in S phase. Poly(ADP-ribose) polymerase 1 co-localizes MIF DNA fork, where activity required resolve and facilitates tumor growth. loss leads mutation frequency increases, cell cycle delays synthesis growth inhibition, which can be rescued by restoring MIF, but not...
27-Hydroxycholesterol (27-HC) is the most abundant oxysterol that increases risk of breast cancer progression. However, little known about epigenetic regulation 27-HC metabolism and its role in tumor initiation. Using genetic mouse mammary human models, we showed here histone reader ZMYND8 was selectively expressed stem cells (BCSCs) promoted epithelial-mesenchymal transition (EMT), BCSC maintenance self-renewal, oncogenic transformation through functions, leading to Mechanistically, a...
Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism breast remains poorly understood. Here, we show ZMYND8 is upregulated and inhibits micronucleus formation cells. Loss of triggered activation the sensor cyclic guanosine monophosphate-adenosine monophosphate synthase micronuclei, leading to further downstream signaling effectors stimulator IFN genes NF-κB, not TANK-binding kinase 1 factor 3, thereby inducing...
SAP30 is a core subunit of the transcriptional corepressor SIN3 complex, but little known about its role in gene regulation and human cancer. Here, we show that was nonmutational oncoprotein upregulated more than 50% breast tumors correlated with unfavorable outcomes patients In various cancer mouse models, found promoted tumor growth metastasis through interaction SIN3A/3B. Surprisingly, canonical silencing not essential for SAP30's tumor-promoting actions. enhanced chromatin accessibility...
Innate behaviors have their origins in the specification of neural fates during development. Within Drosophila, BTB (Bric-a-brac,Tramtrack, Broad) domain proteins such as Fruitless are known to play key roles differentiation underlying responses. We previously identified a gene, which we termed jim lovell (lov), encoding protein with role gravity To understand more fully behavioral this gene investigated its function through several approaches. Transcript and expression patterns been...
Abstract Hypoxia induces thousands of mRNAs and miRNAs to mediate tumor malignancy. However, hypoxia-induced long noncoding RNA (lncRNA) transcriptome their role in triple-negative breast cancer (TNBC) have not been defined. Here we identified lncRNA two human TNBC cell lines by whole sequencing. AC093818.1 was one 26 validated lncRNAs abundantly expressed vitro vivo. 5′- 3′-rapid amplification cDNA ends assays revealed that the isoform 2 a dominant transcript cells thus referred as lncIHAT...
Regulation of multiple adenylyl cyclases (AC) provides unique inputs to mediate the synthesis cAMP, a ubiquitous second messenger that controls many aspects cellular function. On stimulation by G<sub>s</sub>, activities ACs can be further selectively modulated other pathways ensure precise control intracellular cAMP responses specific stimuli. Recently, we reported one AC isoforms, AC7, is uniquely regulated G<sub>13</sub> pathway. To understand more fully molecular mechanism this...
Apoptosis-inducing factor (AIF), as a mitochondrial flavoprotein, plays fundamental role in bioenergetics that is critical for cell survival and also mediates caspase-independent death once it released from mitochondria translocated to the nucleus under ischemic stroke or neurodegenerative diseases. Although alternative splicing regulation of AIF has been implicated, remains unknown which isoform will be induced pathological conditions how impacts functions neurodegeneration adult brain.
Abstract Objective Much of disaster mental health research uses quantitative methods, focusing on numerical prevalence, services, and outcomes. Methods Qualitative methods can provide more detailed, rich, spontaneous insights into personal experiences, yielding important beyond deductive methods. This large-scale qualitative narrative study examined experiences 181 OKC bombing rescue/recovery workers. Results Thematic content the experience arose from accounts bomb blast by workers...
Innate behaviors have their origins in the specification of neural fates during development.Within Drosophila, BTB (Bric-abrac,Tramtrack, Broad) domain proteins such as Fruitless are known to play key roles differentiation underlying responses.We previously identified a gene, which we termed jim lovell (lov), encoding protein with role gravity responses.To understand more fully behavioral this gene investigated its function through several approaches.Transcript and expression patterns been...
<div>Abstract<p>Recruitment of RNA polymerase II to hypoxia-inducible factor (HIF) target genes under normoxia is a prerequisite for HIF-mediated transactivation. However, the underlying mechanism this recruitment remains unknown. Here we report that chromodomain helicase DNA-binding protein 4 (CHD4) physically interacts with α and β subunits HIF1 HIF2 enhances HIF-driven transcriptional programs promote breast cancer progression. Loss HIF1/2α abolished CHD4-mediated tumor growth...
<div>Abstract<p>Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism breast remains poorly understood. Here, we show ZMYND8 is upregulated and inhibits micronucleus formation cells. Loss of triggered activation the sensor cyclic guanosine monophosphate-adenosine monophosphate synthase micronuclei, leading to further downstream signaling effectors stimulator <i>IFN</i> genes NF-κB, not...
<div>Abstract<p>Branched-chain amino acid transaminase 1 (BCAT1) is upregulated selectively in human isocitrate dehydrogenase (IDH) wildtype (WT) but not mutant glioblastoma multiforme (GBM) and promotes IDH<sup>WT</sup> GBM growth. Through a metabolic synthetic lethal screen, we report here that α-ketoglutarate (AKG) kills cells when BCAT1 protein lost, which reversed by reexpression of or supplementation with branched-chain α-ketoacids (BCKA), downstream products...
<div>Abstract<p>Recruitment of RNA polymerase II to hypoxia-inducible factor (HIF) target genes under normoxia is a prerequisite for HIF-mediated transactivation. However, the underlying mechanism this recruitment remains unknown. Here we report that chromodomain helicase DNA-binding protein 4 (CHD4) physically interacts with α and β subunits HIF1 HIF2 enhances HIF-driven transcriptional programs promote breast cancer progression. Loss HIF1/2α abolished CHD4-mediated tumor growth...