A5100345590- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Insect Utilization and Effects
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- interferon and immune responses
- Insect Resistance and Genetics
- Antimicrobial Peptides and Activities
- Silk-based biomaterials and applications
- Insect symbiosis and bacterial influences
- Protein Degradation and Inhibitors
- Biochemical and Structural Characterization
- Skin Protection and Aging
- Image and Object Detection Techniques
- Bacillus and Francisella bacterial research
- Angiogenesis and VEGF in Cancer
- Signaling Pathways in Disease
- melanin and skin pigmentation
- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Lipid metabolism and disorders
- Genomics, phytochemicals, and oxidative stress
- Veterinary Oncology Research
Southwest Medical University
2022-2025
Affiliated Hospital of Southwest Medical University
2025
Shantou University Medical College
2023-2025
Beijing Tian Tan Hospital
2025
Capital Medical University
2025
Shantou University
2023-2025
First Affiliated Hospital of Sichuan Medical University
2023-2024
Southwest University
2013-2023
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2023
Shanghai University of Traditional Chinese Medicine
2023
Microsporidia have attracted much attention because they infect a variety of species ranging from protists to mammals, including immunocompromised patients with AIDS or cancer. Aside the study on Nosema ceranae, few works focused elucidating mechanism in host response microsporidia infection. bombycis is pathogen silkworm pébrine that causes great economic losses industry. Detailed understanding (Bombyx mori) infection by N. helpful for prevention this disease. A genome-wide survey gene...
Hemolymph melanization is a conserved immune response in insects and other arthropods. However, the physiological process of hemolymph system hardly studied. Here, alterations hemocytes were observed by Escherichia coli infection Bombyx mori. Results first showed that there cells aggregating into clusters. it vanished, only part clustered melanized during period intense immunity. The hemocyte numbers immediately decreased following an challenge, slowly increased to peak, then reduced finally...
ABSTRACT Our previous studies have identified mitsugumin 53 (MG53) as a novel regulator for angiogenesis by directly entering endothelial cells and modulating focal adhesion kinase (FAK) activation, but little is known about how rhMG53 taken up mediates cell movement. In the present study, we demonstrated that knockdown of caveolin‐1 clathrin inhibitor, pitstop‐2, both significantly reduced entry into cells, indicating caveolae‐dependent clathrin‐dependent endocytosis during this process....
Abstract Background Diffuse midline glioma (DMG) is an aggressive pediatric brain tumor with limited treatment options. Although natural killer (NK) cell-based immunotherapy promising, its efficacy remains limited, necessitating strategies to enhance NK cell cytotoxicity. Histone deacetylase (HDAC) inhibition demonstrate potential NK-mediated killing. However, the combination of HDAC inhibitors and therapy for DMG unexplored. Methods Patient-derived lines orthotopic mouse models were used...
ABSTRACT l ‐type voltage‐gated calcium channels (LTCC), which are accountable for the influx of extracellular Ca 2+ , have been discovered to play a crucial regulatory role in process autophagy. However, LTCC autophagy induced by influenza A virus (IAV) infection remains largely unknown. Here, we found that IAV (H1N1/PR8) autophagosome accumulation consistent with previous studies but blocked fusion autophagosomes lysosomes. Meanwhile, viral led persistent decline cytoplasmic signal A549...
Abstract Background Mesenchymal stem cells (MSCs) therapies are emerging as a promising approach to therapeutic regeneration. Therapeutic persistence and reduced functional following cell delivery remain critical hurdles for clinical investigation due the senescence of freshly isolated extensive in-vitro passage. Methods Cultured adipose-derived (ASCs) were derived from subcutaneous white adipose tissue mice fed normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal)...
The impairment of the angiopoietin-1 (Ang-1)/Tie-2 signaling pathway has been thought to play a critical role in diabetic complications. However, underlying mechanisms remain unclear. present study aims investigate effects Tie-2 glycation on Ang-1 activation and Ang-1-induced angiogenesis. We identified that was modified by advanced end products (AGEs) aortae derived from high fat diet (HFD)-fed mice methylglyoxal (MGO)-treated human umbilical vein endothelial cells (HUVECs). MGO-induced...
Insect immune-associated phospholipase A2 (PLA2 ) is an important target of pathogen invasion. Melanization, effective defense response, has significant correlations with other immune responses to coordinate attack against invaders. However, the effect PLA2 on melanization not yet been reported in insects or arthropods. In this work, we cloned a gene (BmsPLA2 ), and its protein had characteristic features secreted (sPLA2 ). After injection bacteria, BmsPLA2 expression sPLA2 activity...
Influenza A viruses (IAV), significant respiratory pathogenic agents, cause seasonal epidemics and global pandemics in intra- interannual cycles. Despite effective therapies targeting viral proteins, the continuous generation of drug-resistant IAV strains is challenging. Therefore, exploring novel host-specific antiviral treatment strategies urgently needed. Here, we found that lidocaine, widely used for local anesthesia sedation, significantly inhibited H1N1(PR8) replication macrophages....
The gene-encoding farnesyl diphosphate O-methyltransferase 6 (FAMeT 6) is a member of the family. Our previous studies have demonstrated its influence on juvenile hormone levels in third instar silkworm larvae.
Dopamine is widely distributed in metazoans and implicated many physiological functions. Dopaminergic signaling mediated through two classes of dopamine receptors, D1-like D2-like. Phylogeny analysis reveals that, the receptors probably appeared ahead cnidarian divergence, distinct likely formed prior to separation deuterostomes protostomes, INDRs split from its ancestor before emergence nematodes. Two D2-like genes are closely linked on same scaffold, chromosome region around gene loci show...
The pathogenic hyper-inflammatory response has been regarded as the major cause of severity and death related to acute lung injury (ALI). Hua-ban decoction (HBD) is a classical prescription in traditional Chinese medicine (TCM). It extensively used treat inflammatory diseases; however, its bioactive components therapeutic mechanisms remain unclear. Here, we established lipopolysaccharide (LPS)-induced ALI model that presents hyperinflammatory process explore pharmaco-dynamic effect...
Juvenile hormone (JH) plays a vital role in the growth, development, and reproduction of insects other arthropods. Previous experiments have suggested that BmFAMeT6 could affect duration silk moth’s larval stage. In this study, we established overexpression strain knockout using GAL4/UAS binary hybrid system CRISPR/Cas 9 system, respectively, found stage was shorter, while longer. Our results exhibited both JH titers BmKr-h1 levels larvae third instar were reduced significantly by...