A5079494298- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Nanoplatforms for cancer theranostics
- Amino Acid Enzymes and Metabolism
- Trigeminal Neuralgia and Treatments
- Meningioma and schwannoma management
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Pain Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Brain Metastases and Treatment
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Anesthesia and Pain Management
- Photoacoustic and Ultrasonic Imaging
- Microtubule and mitosis dynamics
- Healthcare and Venom Research
- Protein Degradation and Inhibitors
- Nanoparticle-Based Drug Delivery
- Intracranial Aneurysms: Treatment and Complications
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
Beihang University
2019-2024
Baotou Central Hospital
2024
National Clinical Research Center for Digestive Diseases
2014-2024
North China University of Science and Technology
2011-2024
Woomera Therapeutics
2024
Icahn School of Medicine at Mount Sinai
2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Purpose: Despite the use of fluorescence-guided surgery (FGS), maximum safe resection glioblastoma multiforme (GBM) remains a major challenge.It has restricted surgeons between preoperative diagnosis and intraoperative treatment.Currently, an integrated approach combining assessment with guidance would be significant step in this direction.Experimental design: We developed novel 68 Ga-IRDye800CW-BBN PET/near-infrared fluorescence (NIRF) dual-modality imaging probe targeting gastrin-releasing...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> The near-infrared window II (NIR-II, 1000–1700 nm) imaging, including NIR-IIa (1300–1400 mm) and NIR-IIb (1500-1700 mm), outperforms the I (NIR-I, 700-900 imaging in biological researches. However, advantages of NIR-IIa/IIb human study are ambiguous. This aims to apply glioma resection evaluate their performance by using developed instrument intraoperative image fusion method....
Developing therapies for the activated B-cell like (ABC) subtype of diffuse large lymphomas (DLBCL) remains an area unmet medical need. A subset ABC DLBCL tumors is driven by activating mutations in myeloid differentiation primary response protein 88 (MYD88), which lead to constitutive activation interleukin-1 receptor associated kinase 4 (IRAK4) and cellular proliferation. IRAK4 signaling its catalytic scaffolding functions, necessitating complete removal this escape mechanisms therapeutic...
Interleukin-1 receptor associated kinase 4 (IRAK4) is an essential mediator of the IL-1R and TLR signaling pathways, both which have been implicated in multiple autoimmune conditions. Hence, blocking activity IRAK4 represents attractive approach for treatment diseases. The this serine/threonine dependent on its scaffolding activities; thus, degradation a potentially superior to inhibition. Herein, we detail exploration structure-activity relationships that ultimately led identification...
// Nan Ji 1, 6, * , Danhui Weng 3, Cang Liu 4 Zheng Gu 5 Shizhang Chen 2 Ying Guo Zhong Fan Xiao Wang Jianfei Yanyan Zhao Jianfeng Zhou 3 Jisheng 6 Ding Ma Ning Li 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China YouAn Tongji Hospital Affiliated with College Huazhong University Science and Technology, Wuhan, Friendship Chao-Yang Key Laboratory Brian Tumor, These authors have contributed equally to this work Correspondence to: Ma, e-mail:...
Heat shock protein peptide complex-96 (HSPPC-96) triggers adaptive and innate antitumor immune responses. The safety efficacy of HSPPC-96 vaccination was examined in patients with newly diagnosed glioblastoma multiforme (GBM).In this open-label, single-arm, phase I study, adult were vaccinated combination the standard treatment for GBM after surgical resection. Primary endpoints frequency adverse events progression-free survival (PFS) at 6 months. Secondary included overall (OS), PFS,...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> This translational study aims to investigate the clinical benefits of indocyanine green (ICG) based near-infrared window II (NIR-II) fluorescence image-guided surgery (FGS) on high-grade glioma (HGG) patients. xmlns:xlink="http://www.w3.org/1999/xlink">Methods:</i> Patients were randomly assigned receive FGS or traditional white light (WLS). The detection rate NIR-II was observed....
Surgery is the predominant treatment modality of human glioma but suffers difficulty on clearly identifying tumor boundaries in clinic. Conventional practice involves neurosurgeon's visual evaluation and intraoperative histological examination dissected tissues using frozen section, which time-consuming complex. The aim this study was to develop fluorescent imaging coupled with artificial intelligence technique quickly accurately determine real-time during surgery.Glioma patients (N = 23)...
BackgroundMost malignant brain gliomas (MBGs) are associated with dismal outcomes, mainly due to their late diagnosis. Current diagnostic methods for MBGs based on imaging and histological examination, which limits early detection. Here, we aimed identify reliable plasma lipid biomarkers non-invasive diagnosis MBGs.MethodsUntargeted lipidomic analysis was firstly performed using a discovery cohort (n=107). The data were processed by support vector machine (SVM)-based discriminating model...
Plant-derived extracellular vesicles are functional nanovesicles that have significant applications in both disease prevention and treatment, as well for use drug carriers. Momordica charantia is a widely consumed food has medicinal nutritional properties shown intervention diabetes inflammation caused by oxidative damage. In this study, charantia-derived (MCEVs) were extracted demonstrated to excellent antioxidant activity characterization, lipid composition analysis, protein domain vitro...
Quantifying neuron morphology and distribution at the whole-brain scale is essential to understand structure diversity of cell types. It exceedingly challenging reuse recent technologies single-cell labeling imaging study human brains. We propose adaptive tomography (ACTomography), a low-cost, high-throughput, high-efficacy approach, based on targeting individual cells. established platform inject dyes into cortical neurons in surgical tissues 18 patients with brain tumors or other...
Purpose: Lower-grade gliomas (LGGs) are a group of infiltrative growing glial brain tumors characterized by intricate intratumoral heterogeneity and subtle visual appearance differences from non-tumor tissue, which can lead to errors in pathologic tissue sampling.Although 5-ALA fluorescence has been an essential method for visualizing during surgery, its effectiveness is limited the case LGGs due low sensitivity.Therefore, we developed novel PET/NIR dual-modality image probe targeting...
Although pulsed radiofrequency treatment (PRFT) has been used to treat trigeminal neuralgia (TN) safely, satisfactory improvement is lacking. Recently, much attention paid the PRFT dose and intra-operative parameters. It reported that high-voltage could significantly reduce discogenic pain. However, there no study investigating effects of on TN. The aim this prospective, randomized, double-blinded was evaluate efficacy safety in comparison with standard-voltage for idiopathic Sixty severe TN...
Integrin αvβ3 is overexpressed in both neovasculature and glioma cells. We aimed to evaluate (68)gallium-BNOTA-PRGD2 ((68)Ga-PRGD2) as a new reagent for noninvasive integrin imaging patients. With informed consent, 12 patients with suspicious brain glioma, diagnosed by enhanced magnetic resonance (MRI) scanning, were enrolled undergo (68)Ga-PRGD2 PET/CT (18)F-FDG scans before surgery. The preoperative images compared correlated the pathologically determined WHO grade. Next, expression of...
Background: Intravenous and inhalational anesthesia might have different associations with long-term outcome in cancer patients, reports of adverse effects inhalation anesthesia. However, the patients high-grade glioma (HGG) are not known. Methods: This study investigated 154 who received propofol 140 sevoflurane for maintenance during HGG tumor resection. The primary outcomes were progression-free survival overall survival. Results: Median was 10 months (interquartile range [IQR], 6 to 18)...
The inflammatory microenvironment after acute myocardial infarction (MI) is a key limiting factor in the clinical application of stem cell transplantation and paracrine exosome therapy. Qishen Yiqi Pills contain saponin ingredient called Ginsenoside Rh2 (Rh2) which exhibits certain therapeutic effect on MI. However, mechanism by alleviates improves efficiency exosomes remains enigmatic. Here, we found that attenuated adverse oxygen-glucose deprivation (OGD)-induced cellular injury, an vitro...
Temozolomide (TMZ) is considered a first line chemotherapy drug for glioblastoma (GBM). Unfortunately, the GBM without methylation of O6-methylguanine-DNA methyltransferase (MGMT), accounting about 70% all GBM, shows an inherent resistance to TMZ treatment. Aberrant accumulation neutral lipids, primarily triglycerides (TGs) and cholesteryl esters (CEs), in lipid droplets (LDs) has been recognized as metabolic vulnerability therapy. However, it not known whether MGMT affects GBM. Herein, we...