A5100641276- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- melanin and skin pigmentation
- Animal Nutrition and Physiology
- RNA regulation and disease
- Circular RNAs in diseases
- Biochemical Analysis and Sensing Techniques
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Genetic and phenotypic traits in livestock
- Animal Virus Infections Studies
- Advanced Glycation End Products research
- RNA Research and Splicing
- High Altitude and Hypoxia
- Viral gastroenteritis research and epidemiology
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Molecular Biology Techniques and Applications
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Viral Infections and Immunology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cell Adhesion Molecules Research
Chinese Academy of Agricultural Sciences
2013-2025
Sericultural Research Institute
2023-2025
Ministry of Agriculture and Rural Affairs
2021-2025
Jiangsu University of Science and Technology
2022-2025
Harbin Veterinary Research Institute
2013-2025
China Agricultural University
2017-2024
University of Chinese Academy of Sciences
2024
Jinhua Central Hospital
2024
Beijing Shijitan Hospital
2024
Capital Medical University
2015-2024
The small GTP-binding proteins Rac and Rho are key elements in the signal-transduction pathways respectively controlling formation of lamellipodia stress fibers induced by growth factors or oncogenic Ras. We recently reported that function is necessary for Ras transformation expression constitutively activated Rac1 sufficient to cause malignant transformation. now show that, although V14-RhoA Rat 1 fibroblasts does not on its own, it strongly cooperates with active RafCAAX focus-formation...
Domestic sheep and their wild relatives harbor substantial genetic variants that can form the backbone of molecular breeding, but genome landscapes remain understudied. Here, we present a comprehensive resource for ovine species, landraces improved breeds domestic sheep, comprising high-coverage (∼16.10×) whole genomes 810 samples from 7 species 158 diverse populations. We detected, in total, ∼121.2 million single nucleotide polymorphisms, ∼61 which are novel. Some display significant (P <...
// Nan Ji 1, 6, * , Danhui Weng 3, Cang Liu 4 Zheng Gu 5 Shizhang Chen 2 Ying Guo Zhong Fan Xiao Wang Jianfei Yanyan Zhao Jianfeng Zhou 3 Jisheng 6 Ding Ma Ning Li 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China YouAn Tongji Hospital Affiliated with College Huazhong University Science and Technology, Wuhan, Friendship Chao-Yang Key Laboratory Brian Tumor, These authors have contributed equally to this work Correspondence to: Ma, e-mail:...
There is evidence to suggest that stromal interaction molecule 1 (STIM1) functions as a Ca2+ sensor on the endoplasmic reticulum, leading transduction of signals plasma membrane and opening store-operated channels (SOC). SOC have been detected in vascular smooth muscle cells (VSMCs) are thought an essential role regulation contraction cell proliferation. We hypothesized knockdown STIM1 inhibits VSMC proliferation suppresses neointimal hyperplasia.We examined effect using rat balloon injury...
Abstract Background Dorper and Tan sheep are renowned for their rapid growth exceptional meat quality, respectively. Previous research has provided evidence of the impact gut microbiota on breed characteristics. The precise correlation between gastrointestinal tract peripheral organs in each is still unclear. Investigating metabolic network intestinal organ potential to improve animal performance enhance economic benefits through regulation metabolites. Results In this study, we identified...
Connexins 43 (Cx43) plays a key role in neointimal formation after vascular injury, but the mechanism still needs to be further explored. We hypothesized that gap junction-dependent function of Cx43 mediate intercellular communication has crucial development and progression diseases. The effect mediated by hemichannels on injury was investigated. overexpressed or knockdown rat smooth muscle cell (SMC) transfection pcDNA-Cx43 plasmid small interfering RNA (siRNA) against (siCx43). SMC...
Inflammation and oxidative stress are key steps in the progression of non‑alcoholic steatohepatitis (NASH). Intervention these two processes will therefore benefit NASH treatment. Peroxisome proliferator‑activated receptor γ (PPARγ), as a multiple functional transcription factor, has been reported to be involved prevention progression. However, mechanism by which PPARγ prevents remains elucidated. The present study demonstrated that level was inversely correlated with microRNA...
This study investigates the correlation between antimicrobial resistance and PFGE (Pulsed-Field Gel Electrophoresis) typing in Escherichia coli (E. coli) strains isolated from geese on four farms Heilongjiang Province. A total of 109 isolates were subjected to susceptibility testing using K-B paper diffusion method with 15 different agents. was then performed for further analysis. The results indicated that more than 70% resistant ampicillin, amoxicillin, imipenem, tetracycline, doxycycline....
The Niemann-Pick C1-Like 1 (NPC1L1) protein, primarily expressed in the epithelial cells of small intestine, is essential for cholesterol absorption from both dietary intake and biliary secretion. Despite this conserved function across mammals, full-length coding sequence NPC1L1 remains uncharacterized key avian models including chicken (Gallus gallus), quail (Coturnix japonica), duck (Anas platyrhynchos). In study, we successfully cloned full mRNA chicken, quail, duck, entire 5' 3'...
Object: The receptor for advanced glycation end products (RAGE) may play an important role in inflammatory processes and endothelial activation, likely to accelerate the of atherosclerosis, especially patients with diabetes. factors that regulate expression RAGE are not completely clear. C-reactive protein (CRP) is identified as a key proinflammatory cytokine atherosclerosis. Atherosclerosis also induces reduction dysfunction progenitor cells (EPCs), main cell type vascular repair....
PAX3 (paired box 3) is known to have an important role in melanocyte development through modulation of microphthalmia-associated transcription factor transcription. Here we found that transcriptional activity could be regulated FGF2 (basic fibroblast growth factor)-STAT3 (signal transducer and activator signaling the pigment cells. To study its function vivo, generated a transgenic mouse model expressing driven by tyrosinase promoter tissue-specific fashion. These animals exhibit...
Excessive elevation of arterial blood pressure (BP) at high altitude can be detrimental to our health due acute mountain sickness (AMS) or some AMS symptoms. This prospective and observational study aimed elucidate changes induced by exposure high-altitude hypoxia the relationships these with prevalence, severity, sleep quality exercise condition in healthy young men.A was performed 931 male adults exposed 3,700 m (Lhasa) from low (LA, 500 m). Blood measurement symptom questionnaires were LA...
Background Parkinson’s disease (PD), characterized by the loss of dopaminergic neurons, is a progressive neurodegenerative disorder. Recent research has revealed significant connection between gut microbiota and PD. To gain insight into interests, disciplinary contexts, potential future directions, comprehensive bibliometric analysis was conducted on brain-gut axis PD literature published 2014 2023. Methods Relevant records were gathered from Web Science Core Collection August 11, The data...
Pandemics of coronavirus (CoV)-related infection have been a major issue since the outbreaks SARS, MERS and COVID-2019 in past decades, leading substantial threat to public health. Porcine deltacoronavirus (PDCoV), new swine coronavirus, causes enteropathogenic disease characterized by acute diarrhea, vomiting dehydration suckling piglets poses potential risks cross-species transmission. Here we reveal novel function CDC4 protein restricting PDCoV infection. Ectopic expression suppresses...
The present study aimed to investigate the mechanism of microRNA-129-1-3p (miR-129-1-3p) in regulating hydrogen peroxide (H2O2)-induced autophagic death chicken granulosa cell by targeting mitochondrial calcium uniporter (MCU). results indicated that exposure hens' ovaries H2O2 resulted a significant elevation reactive oxygen species (ROS) levels, as well apoptosis cells and follicular atresia. This was accompanied an upregulation glucose-regulated protein 75 (GRP75), voltage-dependent...
Abstract Hyperpigmentation in Silky Fowl (SF) results aberrant immune cell development. However, how melanocytes regulate B-cell proliferation the bursa of Fabricius (BF) is unclear. To resolve this conundrum, we collected BFs from three-week-old SF and White Leghorn (WL) female chickens for RNA sequencing. The BF development was relatively weaker than WL. transcriptome analyses identified 4848 differentially expressed genes, 326 long noncoding RNAs (lncRNAs), 67 microRNAs SF. genes...