A5100653189- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- RNA Research and Splicing
- Advanced Chemical Sensor Technologies
- Advanced Glycation End Products research
- Asthma and respiratory diseases
- Metabolism and Genetic Disorders
- Cytokine Signaling Pathways and Interactions
- Plant Reproductive Biology
- Immune Response and Inflammation
- Adipose Tissue and Metabolism
- Osteoarthritis Treatment and Mechanisms
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- interferon and immune responses
- IL-33, ST2, and ILC Pathways
- Nicotinic Acetylcholine Receptors Study
- Plant and Fungal Species Descriptions
- Biochemical and Molecular Research
- NF-κB Signaling Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Hypoxia, and Metabolism
- Infant Nutrition and Health
- Heavy Metal Exposure and Toxicity
University of Hong Kong
2025
Ningxia Normal University
2023-2025
Community Care
2025
Beijing University of Chinese Medicine
2025
University of Chinese Academy of Sciences
2023-2024
Kunming Institute of Botany
2008-2024
Chinese Academy of Sciences
2008-2024
Tianjin Children's Hospital
2019-2024
Monell Chemical Senses Center
2013-2023
Chinese Academy of Agricultural Sciences
2016-2023
PlasmoDB (http://PlasmoDB.org) is a functional genomic database for Plasmodium spp. that provides resource data analysis and visualization in gene-by-gene or genome-wide scale. belongs to family of resources are housed under the EuPathDB (http://EuPathDB.org) Bioinformatics Resource Center (BRC) umbrella. The latest release, 5.5, contains numerous new types from several broad categories—annotated genomes, evidence transcription, proteomics evidence, protein function population biology...
Despite significant advances in intensive care therapy and antibiotics, severe sepsis accounts for 9% of all deaths the United States annually. The pathological sequelae are characterized by a systemic inflammatory response, but experimental therapeutics that target specific early mediators [tumor necrosis factor (TNF) IL-1beta] have not proven efficacious clinic. We recently identified high mobility group box 1 (HMGB1) as late mediator endotoxin-induced lethality exhibits significantly...
This review outlines the mechanisms underlying interaction between nervous and immune systems of host in response to an challenge. The main focus is cholinergic anti-inflammatory pathway, which we recently described as a novel function efferent vagus nerve. pathway plays critical role controlling inflammatory through with peripheral a7 subunit-containing nicotinic acetylcholine receptors expressed on macrophages. We describe modulation systemic local inflammation by its interface brain...
Pollen tubes elongate directionally in the extracellular matrix of pistil tissues to transport male gametes from apically located stigma basally ovary for fertilization. The molecular mechanisms underlying directional pollen tube growth are poorly understood. We have purified a glycoprotein, TTS, tobacco stylar transmitting tissue, which supports between and ovary. TTS proteins belong arabinogalactan protein family, they polymerize readily vitro head-to-tail fashion into oligomeric forms....
Multiple voltage-gated potassium (K) channel gene products are likely to be involved in regulating neuronal excitability of any single neuron the mammalian brain. Here we show that two closely related K proteins, mKv1.1 and mKv1.2, present multiple subcellular locations including cell somata, juxta-paranodal regions myelinated axons, synaptic terminals, unmyelinated specialized junctions among proximal dendrites. Staining patterns polypeptides overlap some areas brain, yet each has a unique...
GeneDB (http://www.genedb.org) is a genome database for prokaryotic and eukaryotic pathogens closely related organisms. The resource provides portal to sequence annotation data, which primarily generated by the Pathogen Genomics group at Wellcome Trust Sanger Institute. It combines data from completed ongoing projects with curated annotation, readily accessible web based resource. development of in recent years has focused on providing database-driven tools pipelines, as well catering...
High mobility group box 1 (HMGB), a ubiquitous DNA-binding protein, has been implicated as proinflammatory cytokine and late mediator of lethal endotoxemia. HMGB1 is released by activated macrophages. It amplifies extends the inflammatory response inducing release mediating acute lung injury, anorexia, to tissue necrosis. The kinetics provide wide therapeutic window for endotoxemia because extracellular levels begin increase 12 24 h after exposure stimuli. Here, we demonstrate that domain...
Abstract We recently discovered that a ubiquitous protein, high mobility group box 1 protein (HMGB1), is released by activated macrophages, and functions as late mediator of lethal systemic inflammation. To elucidate mechanisms underlying the regulation HMGB1 release, we examined roles other cytokines in induction release macrophage cell cultures. Macrophage migration inhibitory factor, macrophage-inflammatory 1β, IL-6 each failed to significantly induce even at supraphysiological levels (up...
In plant sexual reproduction, pollen tubes elongate from the stigma, through stylar transmitting tissue, to ovary of pistil deliver male gametes for fertilization. TTS protein is a tobacco tissue glycoprotein shown attract and promote their growth. Here, we show proteins adhere tube surface tips, suggesting that they may serve as adhesive substrates are also incorporated into walls deglycosylated by tubes, provide nutrients this process. Within display gradient increasing glycosylation...
Although domestic cats (Felis silvestris catus) possess an otherwise functional sense of taste, they, unlike most mammals, do not prefer and may be unable to detect the sweetness sugars. One possible explanation for this behavior is that lack sensory system taste sugars therefore are indifferent them. Drawing on work in mice, demonstrating alleles sweet-receptor genes predict low sugar intake, we examined possibility involved initial transduction sweet perception might account indifference...
D-type cyclin/cyclin-dependent kinase (CDK) complexes regulate transit through the restriction point of cell cycle, and thus are required for initiation DNA synthesis. Transgenic mice which overexpress cyclin D1 in heart were produced to determine if deregulation would alter myocardial development. Cyclin overexpression resulted a concomitant increase CDK4 levels adult myocardium, as well modest increases proliferating nuclear antigen CDK2 levels. Flow cytometric morphologic analyses...
Oxidative stress is believed to be the cause of cell death in multiple disorders brain, including perinatal hypoxia/ischemia. Glutamate, cystine deprivation, homocysteic acid, and glutathione synthesis inhibitor buthionine sulfoximine all oxidative injury immature neurons oligodendrocytes by depleting intracellular glutathione. Although vitamin K not a classical antioxidant, we report here novel finding that 1 2 (menaquinone-4) potently inhibit depletion-mediated primary cultures...
Peroxisome proliferator-activated receptor ␥ (PPAR␥) activity is regulated through association with ligands that include the thiazolidinedione class of antidiabetic drugs, as well derivatives polyunsaturated fatty acids.Induction PPAR␥ target gene expression involves ligand-dependent reconfiguration ligandbinding domain (LBD), followed by recruitment specific transcriptional coactivators.In this study, we have identified an amino acid (F372) within helix 7 LBD required for response to...
Taste disorders, including taste distortion and loss, negatively impact general health quality of life. To understand the underlying molecular cellular mechanisms, we set out to identify inflammation‐related molecules in tissue assess their role development dysfunctions. We found that 10 12 mammalian Toll‐like receptors (TLRs), type I II interferon (IFN) receptors, downstream signaling components are present tissue. Some TLRs appear be selectively or more abundantly expressed buds than...
Members of the erythroid Krüppel-like factor (EKLF) multigene family contain three C-terminal zinc fingers, and they are typically expressed in a limited number tissues. EKLF, founding member, transactivates beta-globin promoter by binding to CACCC motif. EKLF is essential for expression gene as demonstrated deletion experiments mice. Using DNA probe from finger region we cloned cDNA encoding member this human vascular endothelial cell library. Sequence analysis indicated that our clone,...
Abstract Background The mammalian taste bud, a complex collection of sensory cells, supporting and immature basal is the structural unit for detecting stimuli in oral cavity. Even though cells bud undergo constant turnover, homeostasis maintained by balancing cell proliferation death. Compared with nongustatory lingual epithelial express higher levels several inflammatory receptors signalling proteins. Whether inflammation, an underlying condition some diseases associated disorders,...