A5031800532- Redox biology and oxidative stress
- Sulfur Compounds in Biology
- RNA Interference and Gene Delivery
- Advanced Proteomics Techniques and Applications
- Organoselenium and organotellurium chemistry
- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- Phagocytosis and Immune Regulation
- Nanoparticle-Based Drug Delivery
- Mass Spectrometry Techniques and Applications
- Toxic Organic Pollutants Impact
- 3D Printing in Biomedical Research
- Reproductive Biology and Fertility
- Atrial Fibrillation Management and Outcomes
- Erythrocyte Function and Pathophysiology
- Microtubule and mitosis dynamics
- Cancer Cells and Metastasis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Streptococcal Infections and Treatments
- Selenium in Biological Systems
- Pharmacogenetics and Drug Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
China Three Gorges University
2016-2025
Tongde Hospital of Zhejiang Province
2025
Affiliated Hospital of Guangdong Medical College Hospital
2024
Guangdong Medical College
2024
Jinan University
2016-2024
Peking University
2024
Lishui City People's Hospital
2024
Wenzhou Medical University
2024
Union Hospital
2016-2024
The blood-brain barrier (BBB), a dynamic and complex formed by endothelial cells, can impede the entry of unwanted substances – pathogens therapeutic molecules alike into central nervous system (CNS) from blood circulation. Taking account fact that CNS-related diseases are largest fastest growing unmet medical concern, many potential protein- nucleic acid-based medicines have been developed for purposes. However, due to their poor ability cross BBB plasma membrane, above-mentioned...
Thiol-dependent enzymes, including the thioredoxin (Trx) and glutathione (GSH) systems, have recently been found as promising bactericidal targets in multidrug-resistant (MDR) bacteria. We previously discovered that silver acted synergistically with ebselen inhibition of Trx system also resulted a fast depletion GSH Gram-negative Silver has by others to improve sensitivity bacteria certain conventional antibiotics. Here, we synergistic antibacterial effects four antibiotics was correlated...
The prevalence of non-alcoholic fatty liver disease (NAFLD) and its related mortality is increasing at an unprecedented rate. Traditional Chinese medicine (TCM) has been shown to offer potential for early prevention treatment NAFLD. new mechanism "Shenling Baizhu San" (SLBZS) examined in this study the NAFLD preclinical level.
ABSTRACT The insufficient infiltration and functional inhibition of CD8 + T cells due to tumor microenvironment (TME) are considered enormous obstacles anti‐tumor immunotherapy. Herein, a pH‐responsive core‐shell manganese phosphate nanomodulator co‐loading siPD‐L1 Mn 2+ into nanoparticles coated with hyaluronic acid was prepared, which aimed at the bidirectional reprogramming microenvironment: (1) “Brakes off,” restoring function by knockdowning PD‐L1 expression cells; (2) “Step on...
The synergistic combination of photothermal and RNA interference therapy demonstrates great potential for effective treatment metastatic breast cancer, but their efficacy is limited by the poor delivery efficiency to tumor. Herein, it reported that an albumin biomimetic nanocorona (DRI‐S@HSA) can accomplish high accumulation deep penetration within tumor tissues, thereby holding promise therapy. DRI‐S@HSA prepared camouflaging human serum (HSA) onto IR‐780 small interfering RNA‐loaded...
Abstract Multidrug‐resistant ( MDR ) Gram‐negative bacteria account for a majority of fatal infections, and development new antibiotic principles drugs is therefore outstanding importance. Here, we report that five most clinically difficult‐to‐treat are highly sensitive to synergistic combination silver ebselen. In contrast, has no toxicity with ebselen on mammalian cells. The causes rapid depletion glutathione inhibition the thioredoxin system in bacteria. Silver ions were identified as...
Urine and cerebrospinal fluid (CSF) are two important biofluids used for disease biomarker discovery. For differential proteomic analysis, it is essential to evaluate individual gender variations. In this study, we characterized urinary CSF proteomes of 14 healthy volunteers with regard variations using 2DLC-MS/MS analysis 8-plex iTRAQ quantification. A total 968/512 urinary/CSF proteins were identified, 406/280 quantified in all individuals. The median inter-individual coefficients...
The efficient and specific drug delivery to brain tumor is a crucial challenge for successful systemic chemotherapy. To overcome these limitations, here tumor‐triggered programmed wormlike micelle reported with precise targeting deep penetration treat malignant gliomas, which composed of pH‐responsive mPEG‐ b ‐PDPA copolymer bioreducible cyclic RGD peptide targeted cytotoxic emtansine (DM1) conjugates (RGD‐DM1). RGD‐DM1 loaded nanoscaled micelles (RNW) exhibit nanometer‐sized assemblies the...
Cancer metastasis is the leading reason for high mortality of breast cancer.Herein, we report on a pH-responsive host-guest nanosystem succinobucol (PHN) with pH-stimuli controlled drug release behavior to improve therapeutic efficacy lung cancer.PHN was composed host polymer β-cyclodextrin linked multiple arms N,N-diisopropylethylenediamine (βCD-DPA), guest adamantyl end-capped methoxy poly(ethylene glycol) (mPEG-Ad), and active agent succinobucol.PHN comprises nanometer-sized homogenous...
As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is promising antibacterial drug target. Ebselen, an organo-selenium with well-characterized toxicology and pharmacology, was recently reported to have potent activity against Staphylococcus aureus. In this paper, we demonstrated that ebselen has strong bactericidal multidrug-resistant (MDR) S. aureus based on taking TrxR as major target disruption of the redox microenvironment. Further, topical therapeutic efficacy for staphylococcal...
Background Anxiety and depression are common in patients with chronic obstructive pulmonary disease (COPD), especially older adult patients. This can complicate the progression lead to increased clinical economic burden. We sought investigate burdens associated presence of anxious and/or depressive symptoms among COPD Methods screened 579 aged over 60 years diagnosed via a lung function test following 2017 Global Initiative Chronic Obstructive Lung Disease (GOLD) guidelines. were measured...
Abstract Ferroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with predominant intracellular lipid peroxidation. In recent years, ferroptosis has gained more interest people in the treatment mechanism targeted tumors. mTOR, always overexpressed tumor, controlling cell growth metabolic activities, an important role both autophagy ferroptosis. Interestingly, selective types autophay plays promoting ferroptosis, which related to mTOR some pathways...