A5016525428- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Ferroptosis and cancer prognosis
- Drug Solubulity and Delivery Systems
- Drug Transport and Resistance Mechanisms
- RNA Interference and Gene Delivery
- Phytoestrogen effects and research
- Immune cells in cancer
- Advancements in Transdermal Drug Delivery
- Peptidase Inhibition and Analysis
- Pharmacological Effects and Toxicity Studies
- Proteins in Food Systems
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer Cells and Metastasis
- Protein Interaction Studies and Fluorescence Analysis
- Click Chemistry and Applications
- Spectroscopy and Chemometric Analyses
- Cancer Research and Treatments
- Dendrimers and Hyperbranched Polymers
- Food composition and properties
- Stochastic processes and financial applications
- Tea Polyphenols and Effects
Sichuan Agricultural University
2021-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Zhejiang Chinese Medical University
2025
Shanghai Jiao Tong University
2015-2024
Jilin University
2024
GTx (United States)
2019
National Institutes for Food and Drug Control
2005-2018
Wells Fargo (United States)
2018
Zhengzhou University
2008-2010
Kyoto Pharmaceutical University
2006-2008
Single therapy for tumor always exerts limited ability the constraints on reaction condition and unavoidable multidrug resistance, which seriously influences effect in clinic. Herein, a combination treatment nanosystem (MP@PI) based chemodynamic (CDT) photothermal (PTT) is constructed triggering ferroptosis/pyroptosis, metal-organic framework (MOF) modified with polydopamine (PDA) IR820 to loaded piperlongumine (PL). The MOF PL respectively served as iron source H2O2 source, performing...
Novel nanoMof (Tf-LipoMof@PL) can induce both ferroptosis and pyroptosis by iron ROS enrichment, which provides new choices for anti-cancer therapy.
Abstract Ferritin internalized into tumor cells is degraded and releases iron ions via ferritinophagy. Iron participate in Fenton reaction to produce reactive oxygen species for lipid peroxidation ferroptosis. Inhibition of indoleamine‐2,3‐dioxygenase (IDO) decreases tryptophan elimination induce T activation immunosuppression relief. The active targeting nanoparticles containing ferritin a pH‐sensitive molecular‐switch (FPBC@SN) are developed utilize ferritinophagy‐cascade ferroptosis...
Triple-negative breast cancer (TNBC) patients have a predisposition to poor prognosis due the strong malignancy. Ferroptosis, new form of cell death, is candidate treatment for TNBC owing its effectiveness in killing cells. However, some cells exhibit an abnormal tumor metabolism, especially ferroptosis suppressor protein 1 (FSP1)-mediated ubiquinone redox which can promote resistance. Here, rosuvastatin (RSV) encapsulated silk fibroin (SF) nanoparticle (designated as Cu-SF(RSV) NPs)...
Effects of Labrasol and other pharmaceutical excipients on the intestinal transport absorption rhodamine123, a P-glycoprotein substrate (P-gp) were examined. Intestinal studies examined by an in vitro diffusion chamber method situ closed loop method. We evaluated membrane damage produced measuring release protein alkaline phosphatase (ALP). (0.075—0.1% (v/v)) increased absorptive rhodamine123 decreased its secretory studies. However, did not change Lucifer yellow, non-P-gp substrate,...
Multifunctional nanoparticles, Fol/R7 NPs, based on pH-sensitive PLGA-PEG-folate and cell penetrating peptide R7-conjugated PLGA-PEG, were constructed for targeting vincristine sulfate (VCR) to tumor overcoming multidrug resistance (MDR). In this study, the pH-triggered VCR release was 65.6% during 8 h in pH 5.0, but only 35.8% 7.4, demonstrating that a large amount of released rapidly at weak acidic environment. The VCR-Fol/R7 NPs could significantly enhance cellular uptake cytotoxicity...
Interstitial fluid pressure (IFP) in tumor is much higher than that normal tissue, and it constitutes a great obstacle for the delivery of antitumor drugs, thus becoming potential target cancer therapy. In this study, cationic nanostructured lipid carriers (NLCs) were modified by low molecular weight gelatin to achieve desirable reduction IFP improve drug delivery. way, chemotherapy formulations on proliferation pulmonary metastasis was further improved. The nanoparticles used load three...
Abstract: The aim of this research was to increase the oral bioavailability daidzein by formulations poly(lactic-co-glycolic) acid (PLGA) nanoparticles loaded with daidzein. Amongst various traditional and novel techniques preparing daidzein-loaded PLGA nanoparticles, phospholipid complexes cyclodextrin inclusion were selected. average drug entrapment efficiency, particle size, zeta potential 81.9% ± 5%, 309.2 14.0 nm, -32.14 2.53 mV 83.2% 7.2%, 323.2 4.8 -18.73 1.68 mV, respectively....
Cancer metastasis is the leading reason for high mortality of breast cancer.Herein, we report on a pH-responsive host-guest nanosystem succinobucol (PHN) with pH-stimuli controlled drug release behavior to improve therapeutic efficacy lung cancer.PHN was composed host polymer β-cyclodextrin linked multiple arms N,N-diisopropylethylenediamine (βCD-DPA), guest adamantyl end-capped methoxy poly(ethylene glycol) (mPEG-Ad), and active agent succinobucol.PHN comprises nanometer-sized homogenous...
Extracellular matrix (ECM) accumulating in the tumor microenvironment (TME) is generated by tumor-associated fibroblasts. It can elevate interstitial fluid pressure and form dense barriers tissues. Consequently, nanocarriers are hindered from permeating into deeper sites. Thus, programmed drug-releasing nanoparticles, G(TM)PPSP, were developed for TME remodeling breast cancer therapy. Gelatin nanoparticles linked with platinum (PtNPs) to obtain G(TM)PPSP a size of 214.0 ± 5.0 nm. Telmisartan...
The effect of eugenol on colchicine transport across an isolated rat intestinal membrane was studied using in vitro diffusion chamber system. We found that increased the absorptive drug efficiently. absorption oral administrative nanoemulsion formulation also demonstrated vivo. prepared with isopropyl myristate, eugenol, Tween80, ethanol and water, used as oil phase formulation; average particle size this 41.2 ± 7.2 nm. permeation significantly different from control group (0.2 mM...