A5023563596- Advancements in Solid Oxide Fuel Cells
- Electronic and Structural Properties of Oxides
- Fuel Cells and Related Materials
- Malaria Research and Control
- Magnetic and transport properties of perovskites and related materials
- Catalysis and Oxidation Reactions
- Nuclear Materials and Properties
- Synthesis and Catalytic Reactions
- Catalytic Processes in Materials Science
- Natural Compounds in Disease Treatment
- Chemical Looping and Thermochemical Processes
- Phase Equilibria and Thermodynamics
- Electrocatalysts for Energy Conversion
- Nuclear Receptors and Signaling
- Machine Learning in Materials Science
- Membrane Separation and Gas Transport
- Carbon Dioxide Capture Technologies
- Apelin-related biomedical research
- Neuropeptides and Animal Physiology
- Click Chemistry and Applications
- Nanoparticles: synthesis and applications
- RNA Interference and Gene Delivery
- Research on Leishmaniasis Studies
- Thermal Expansion and Ionic Conductivity
- HIV/AIDS drug development and treatment
Idaho National Laboratory
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Zhengzhou University of Light Industry
2025
Clemson University
2018-2024
Guiyang Medical University
2023
Affiliated Hospital of Guizhou Medical University
2023
University of Science and Technology of China
2017-2022
China Academy of Chinese Medical Sciences
2019-2021
Xinjiang Institute of Materia Medica
2021
Institute of Chinese Materia Medica
2019-2021
Proton-conducting ceramics (PCCs) are of considerable interest for use in energy conversion and storage applications, electrochemical sensors, separation membranes. PCCs that combine performance, efficiency, stability, an ability to operate at low temperatures particularly attractive. This review summarizes the recent progress made development low-temperature proton-conducting (LT-PCCs), which defined as operating temperature range 25–400 °C. The structure these ceramic materials,...
Abstract A substantial challenge worldwide is emergent drug resistance in malaria parasites against approved drugs, such as chloroquine (CQ). To address these unsolved CQ issues, only rare examples of artemisinin (ART)‐based hybrids have been reported. Moreover, protein targets not identified yet, and the reason for superior efficacy still known. Herein, we report synthesis novel ART–isoquinoline ART–quinoline showing highly improved potencies CQ‐resistant multidrug‐resistant P. falciparum...
ABSTRACT The insufficient infiltration and functional inhibition of CD8 + T cells due to tumor microenvironment (TME) are considered enormous obstacles anti‐tumor immunotherapy. Herein, a pH‐responsive core‐shell manganese phosphate nanomodulator co‐loading siPD‐L1 Mn 2+ into nanoparticles coated with hyaluronic acid was prepared, which aimed at the bidirectional reprogramming microenvironment: (1) “Brakes off,” restoring function by knockdowning PD‐L1 expression cells; (2) “Step on...
Glycyrrhetinic acid (GA) shows great efficiency against non-small cell lung cancer (NSCLC), but the detailed mechanism is unclear, which has limited its clinical application. Herein, we investigated potential targets of GA NSCLC by activity-based protein profiling (ABPP) technology and combination histopathology proteomics validation. In vitro in vivo results indicated significantly inhibited via promotion peroxiredoxin-6 (Prdx6) caspase-3 (Casp3)-mediated mitochondrial apoptosis. This...
Abstract Artemisinins are a family of sesquiterpene lactones originally derived from the sweet wormwood ( Artemisia annua ). Beyond their well‐characterized role as frontline antimalarial drugs, artemisinins have also received increased attention for other potential pharmaceutical effects, which include antiviral, antiparsitic, antifungal, anti‐inflammatory, and anticancer activities. With concerted efforts in further preclinical clinical studies, artemisinin‐based drugs to be viable...
High-performance noble metal-free gas sensors are crucial for widespread applications in various areas. Non-Nernstian electrochemical have attracted tremendous attention, but limited by the high cost and low efficiency of Pt electrode. Moreover, responses from different electrodes usually same polarity, degrading sensor performance. Here we report a reverse response on series mixed ionic–electronic conductors (MIECs). Exemplary SrFe0.5Ti0.5O3-δ (SFT50) perovskite shows excellent H2 sensing...
The composition of serum is extremely complex, which complicates the discovery new pharmacodynamic biomarkers via proteome for disease prediction and diagnosis. Recently, nanoparticles have been reported to efficiently reduce proportion high-abundance proteins enrich low-abundance in serum. Here, we synthesized a silica-coated iron oxide nanoparticle developed highly efficient reproducible protein corona (PC)-based proteomic analysis strategy improve range analysis. We identified 1,070 with...
One major challenge for the further development of solid oxide fuel cells is obtaining high-performance cathode materials with sufficient stability against reactions CO2 present in ambient atmosphere. However, enhanced often achieved by using material systems exhibiting decreased performance metrics. The phenomena underlying and trade-off has not been well understood. This paper uses antimony-doped SrFeO3-δ as a model to shed light on relationship between structure, stability,...
Abstract Background Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions people in developing countries. In the history anti-malaria campaign, chloroquine (CQ) has played an indispensable role, however, its mechanism action (MoA) not fully understood. Methods We used principle photo-affinity labeling and click chemistry-based functionalization design CQ probe developed combined deconvolution strategy activity-based protein profiling (ABPP) mass...
An eco-friendly decaboxylative cyclization in water has been developed to construct 4-quinolones from readily available isatoic anhydrides and 1,3-dicarbonyl compounds.
Understanding the mechanisms of proton conduction at interface materials enables development a new generation protonic ceramic conductors low temperatures (<150 °C) through water absorption and transport on surface grain boundaries. Conductivity measurements under Ar-3% H2O D2O revealed σ(H2O)/σ(D2O) ratio approximately 2, indicating hopping-based mechanism for interface. In situ Raman spectroscopy was performed water-saturated, porous, nanostructured TiO2 membranes to directly observe...
Protonic ceramic fuel cells have attracted much attention due to their good performance at intermediate temperatures (400–700 °C). However, the highly resistive electrolyte-cathode interface has been discovered be a crucial obstacle inhibiting further cell improvements in performance. Herein, using model material system of BaCe0.7Zr0.1Y0.1Yb0.1O3-δ electrolyte, 40 wt % + 60 NiO anode, and BaCo0.4Fe0.4Zr0.1Y0.1O3-δ cathode, we proved that laser ablation electrolyte surfaces could accurately...
Abstract Addressing the challenges posed by inferior electrochemical performance at low temperatures and uncertain Faradaic efficiency (FE) represents a pivotal undertaking in development of high efficient proton‐conducting solid oxide electrolysis cells (P‐SOECs). In this work, novel oxygen electrode material BaCo 0.8 Zr 0.1 Zn O 3‐δ (BCZZ) is first designed synthesized. At 600 °C, P‐SOECs with BCZZ achieve an current density 1.98 A cm −2 ≈90% FE 1.3 V. Utilizing 1‐inch as reliable...