A5067122530- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Catalytic C–H Functionalization Methods
- Quinazolinone synthesis and applications
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Synthesis and Catalytic Reactions
- Electrocatalysts for Energy Conversion
- Gold and Silver Nanoparticles Synthesis and Applications
- Plasmonic and Surface Plasmon Research
- Bone Metabolism and Diseases
- Catalytic Cross-Coupling Reactions
- Advanced battery technologies research
- Sulfur-Based Synthesis Techniques
- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Nanoparticle-Based Drug Delivery
- Synthesis and Biological Evaluation
- Nanopore and Nanochannel Transport Studies
- Covalent Organic Framework Applications
- Membrane Separation and Gas Transport
- Asymmetric Hydrogenation and Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
Southwest University
2016-2025
Xinjiang Academy of Agricultural Sciences
2025
Nanjing University
2013-2024
Beijing University of Technology
2022-2024
Hebei University
2018-2023
University of Jinan
2022-2023
China University of Petroleum, East China
2021
State Key Laboratory of Pollution Control and Resource Reuse
2017-2020
Zhengzhou University
2009-2019
Chinese Academy of Sciences
2019
Mo doped Ni<sub>2</sub>P nanowire arrays were prepared with enhanced activity toward the hydrogen evolution reaction at all pH values.
Abstract The chemotherapy of glioblastoma is severely hindered by the immunosuppressive tumor microenvironment, especially growth factor β (TGF‐β), an cytokine. In this study, it proposed to employ RNAi‐based immunomodulation modify immune microenvironment and improve effect chemotherapy. Herein, a nanotheranostic system (Angiopep LipoPCB(Temozolomide+BAP/siTGF‐β), ALBTA) with dual targeting ROS response established for intracranial treatment. traceable nanoparticles exhibit strong siRNA...
Two-dimensional (2D) Pt-group ultrathin nanosheets (NSs) are promising advanced electrocatalysts for energy-related catalytic reactions. However, improving the electrocatalytic activity of 2D NSs through addition abundant grain boundaries (GBs) and understanding underlying formation mechanism remain significant challenges. Herein, we report controllable synthesis a series Rh-based nanocrystals (e.g., Rh nanoparticles, NSs, with GBs) CO-mediated kinetic control route. In light NSs' structural...
In chemotherapy, it is a great challenge to recruit endogenous stimuli instead of external intervention for targeted delivery and controlled release; microRNAs are the most promising candidates due their vital role during tumorigenesis significant expression difference. Herein, amplify low abundant in live cells, we designed stimuli-responsive DNA Y-motif codelivery siRNA Dox, which cargo release was achieved via enzyme-free cascade amplification with microRNA as trigger ATP (or H+) fuel...
Nanocarrier surface chemistry plays a vital role in mediating cell internalization and enhancing delivery efficiency during vivo chemotherapy. Inspired by the ability of proteins to alter their conformation mediate functions, pH‐/thermal‐/glutathione‐responsive polymer zipper consisting cell‐penetrating poly(disulfide)s thermosensitive polymers bearing guanidinium/phosphate (Gu + /pY − ) motifs spatiotemporally tune composition nanocarriers for precise tumor targeting efficient drug is...
Base-switched methylenation and formylation using tetramethylethylenediamine (TMEDA) as a carbon source have been achieved under mild conditions, catalyzed by CuCl2, with atmospheric oxygen oxidant. Bisindolylmethanes, diphenylmethanes 3-formylindoles were synthesized excellent regioselectivity good yield.
Understanding and tuning the crystal-facet-dependent catalytic properties of catalysts are great importance for selective oxidation polyols. Herein, a series α-Mn2O3 with various morphologies (octahedron, truncated octahedron, cube) successfully synthesized enhanced glycerol to glycolic acid. Our results show that different performances Mn2O3 originated from chemical nature (001) (111) facets. Multicharacterizations density functional theory calculations revealed surface oxygen vacancies on...
An iron-catalyzed one-pot one-step oxidative system has been successfully developed in the conversion of primary alcohols into nitrogen-containing heterocycles, such as quinazolinone, quinazoline and 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives.
High-quality Au@ZnO core–shell nanoparticle (NP) array films were easily and efficiently fabricated through an air/water interfacial self-assembly. These materials have remarkable visible light absorption capacity fascinating performance in photoelectrochemical (PEC) water splitting with a photocurrent density of ∼3.08 mA/cm2 at 0.4 V, which is superior to most ZnO-based photoelectrodes studies. Additionally, the interesting PEC could be effectively adjusted by altering thickness ZnO shell...
Abstract A novel potassium iodide‐catalyzed three‐component synthesis of quinazolines via benzylic CH bonds amination was developed. Commonly used ammonia salt and the sp 3 carbon in commercially available methylarenes were as nitrogen C 1 sources, respectively. Mechanistic studies indicated that an aryl aldehyde is involved a key intermediate reaction. magnified image
An n-Bu4NI catalyzed domino reaction that involves selective dual amination of sp(3) C-H bonds has been developed. The protocol affords a facile and efficient approach to the synthesis imidazo[1,5-c]quinazolines under mild conditions.
In vivo monitoring of cargo protein delivery is critical for understanding the pharmacological efficacies and mechanisms during cancer therapy, but it still remains a formidable challenge because difficulty in observing nonfluorescent proteins at high resolution sensitivity. Here we report an outer-frame-degradable nanovehicle featuring near-infrared (NIR) dual luminescence real-time tracking vivo. Upconversion nanoparticles (UCNPs) fluorophore-doped degradable macroporous silica (DS) with...
A single gold nanopore with high surface enhanced Raman spectroscopy (SERS) activity is fabricated on the tip of a glass nanopipette.
Layered/two-dimensional covalent organic frameworks (2D COF) are crystalline porous materials composed of light elements linked by strong bonds. Interlayer force is one the main factors directing formation a stacked layer structure, which plays vital role in stability, crystallinity, and porosity layered COFs. The as-developed new way to modulate interlayer imine-linked 2D TAPB-PDA-COF (TAPB = 1,3,5-tris(4-aminophenyl)benzene, PDA terephthaldehyde) only adjusting pH solution. At alkaline...
A reliable, rapid, cost-effective, and simple method for the detection of biomolecules would greatly promote research analytical single molecules. nanopore-based technique is promising detecting biomolecules. Conventional electrochemical nanopores cannot distinguish precisely because their fast translocation speed limited information. Therefore, it highly desirable to develop surface-enhanced Raman scattering (SERS) obtain multidimensional Herein, we designed fabricated gold nanotriangle...
A facile alkenylation of quinazolines with unactivated terminal alkynes has been achieved in the presence KOtBu without aid any transition metal catalysts. The reaction is carried out under very mild conditions and shows a high stereoselectivity. possible radical-based mechanism also explored.
Probing the orientation and oxygenation state of single molecules (SMs) is great importance for understanding advanced structure individual molecules. Here, we manipulate transporting through hot spot a sub-10 nm conical gold nanopore acquire multidimensional structural information SMs by surface enhanced Raman scattering (SERS) detection. The size shape plasmonic guarantee its high detection sensitivity. SERS spectra show correlation with orientations small-sized rhodamine 6G (R6G) during...