A5100327617- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- CRISPR and Genetic Engineering
- Alzheimer's disease research and treatments
- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Virus-based gene therapy research
- Pain Mechanisms and Treatments
- Conducting polymers and applications
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
- Polydiacetylene-based materials and applications
- Lipid Membrane Structure and Behavior
- Immunotherapy and Immune Responses
- Photodynamic Therapy Research Studies
- Electrochemical sensors and biosensors
- Gold and Silver Nanoparticles Synthesis and Applications
- Dendrimers and Hyperbranched Polymers
- Characterization and Applications of Magnetic Nanoparticles
- Photochromic and Fluorescence Chemistry
- DNA and Nucleic Acid Chemistry
Institute of Process Engineering
2016-2025
Shaanxi Normal University
2024-2025
University of Chinese Academy of Sciences
2013-2025
Southern Medical University
2022-2025
Nanjing General Hospital of Nanjing Military Command
2024-2025
Nanjing University
2024-2025
State Key Laboratory of Chemical Engineering
2025
China-Japan Friendship Hospital
2025
Boston University
2013-2024
Tianjin University
2004-2024
Recent studies have indicated an important role of chemokines such as CCL2 in the development chronic pain. However, distinct roles different and maintenance neuropathic pain their interactions with neurons not been clearly elucidated. We found that spinal nerve ligation (SNL) only induced persistent symptoms, including mechanical allodynia heat hyperalgesia, but also produced sustained CXCL1 upregulation cord. Double staining immunofluorescence situ hybridization revealed was primarily...
Abstract The chemotherapy of glioblastoma is severely hindered by the immunosuppressive tumor microenvironment, especially growth factor β (TGF‐β), an cytokine. In this study, it proposed to employ RNAi‐based immunomodulation modify immune microenvironment and improve effect chemotherapy. Herein, a nanotheranostic system (Angiopep LipoPCB(Temozolomide+BAP/siTGF‐β), ALBTA) with dual targeting ROS response established for intracranial treatment. traceable nanoparticles exhibit strong siRNA...
The treatment of Parkinson's disease (PD) has been hindered by the complex pathologies and multiple membrane barriers during drug delivery. Although exosomes derived from mesenchymal stem cells (MSCs) have great potential for PD, MSC-derived alone could not fully meet therapeutic requirements due to their limitation in therapy Here, we develop a self-oriented nanocarrier called PR-EXO/PP@Cur that combines with curcumin. can be across directly release drugs into cytoplasm target after...
Hydrogen therapy, an emerging therapeutic strategy, has recently attracted much attention in anticancer medicine. Evidence suggests that hydrogen (H2) can selectively reduce intratumoral overexpressed hydroxyl radicals (•OH) to break the redox homeostasis and thereby lead stress cell damage. However, inability achieve stable storage efficient delivery hinders development of therapy. Furthermore, oxygen (O2) deficiency tumor microenvironment (TME) electron-hole separation inefficiency...
Abstract Volatile solid additives (VSAs) have emerged as one of the most effective strategies for optimizing active layer morphology organic solar cells (OSCs). In this study, two VSAs, HBT‐1 and HBT‐2, are designed synthesized to investigate effect VASs’ conformation on photovoltaic performances. Compared HBT‐1, HBT‐2 incorporates internal noncovalent conformational locks (NoCLs), resulting in reduced disorder, improved molecular planarity, enhanced crystallinity. These features...
A new generation of photothermal theranostic agents based on assembling 6 nm gold nanoparticles (AuNPs) is developed by using a novel comb-like amphipathic polymer as the template. The small AuNPs are assembled into DOX@gold nanomicelles, which show strong absorbance in near-infrared region, for multimodal bioimaging and highly effective vivo chemotherapy therapy.
Protein misfolding and aggregation are associated with more than twenty diseases, such as neurodegenerative diseases metabolic diseases. The amyloid oligomers fibrils may induce cell membrane disruption lead to apoptosis. A great number of studies have focused on discovery inhibitors which prevent or treat amyloidosis Polyphenols been extensively studied a class inhibitors, several polyphenols under clinical trials anti-neurodegenerative drugs. As oxidative intermediates natural polyphenols,...
As nanotheranostics, Congo red/Rutin-MNPs combine the abilities of diagnosis and treatment Alzheimer's disease (AD). The biocompatible nanotheranostics system based on iron oxide magnetic nanoparticles, with ultrasmall size excellent properties, can specifically detect amyloid plaques by resonance imaging, realize targeted delivery AD therapeutic agents, achieve drug controlled release H2O2 response, prevent oxidative stress. a service to our authors readers, this journal provides supporting...
Autophagy plays an important role in Alzheimer's disease (AD). It has been reported that autophagic flux is altered patients with AD, and application of the autophagy enhancer rapamycin may alleviate cognitive impairment amyloid-β (Aβ) neuropathology transgenic animal model AD. Since also immune suppressor, there a concern long-term use bring severe unwanted side effects. The aim this study to test if carbamazepine (CBZ), anti-epileptic drug potent enhancement effect, anti-AD effects...
The targeted nanocomplex efficiently treats Parkinson’s disease by clearing α-synuclein and immune activation.
Tissue-specific overexpression of the human systemic amyloid precursor transthyretin (TTR) ameliorates Alzheimer's disease (AD) phenotypes in APP23 mice. TTR–β-amyloid (Aβ) complexes have been isolated from and some AD brains. We now show that substoichiometric concentrations TTR tetramers suppress Aβ aggregation vitro via an interaction between thyroxine binding pocket tetramer residues 18–21 (nuclear magnetic resonance epitope mapping). The K D is micromolar, stoichiometry <1 for...
The proinflammatory cytokines tumor necrosis factor (TNF) α and interleukin (IL) 1β have been strongly implicated in the pathogenesis of neuropathic pain, but intracellular signaling these glial cells is not fully understood. TNF receptor-associated 6 (TRAF6) plays a key role signal transduction receptor superfamily IL-1 superfamily. In this study, we investigated TRAF6 pain mice after spinal nerve ligation (SNL). SNL induced persistent upregulation cord. Interestingly, was mainly...
Rationale: It has been reported that peroxisome proliferator activated receptor γ (PPARγ) level decreases significantly in the brains of Alzheimer's disease (AD) patients and mice models, while mechanism is unclear.This study aims to unravel amyloid β (Aβ) PPARγ attempted discover lead compound preserves PPARγ. Methods:In APP/PS1 transgenic Aβ treated microglia, interaction between HSP90 were analyzed by western blot.Using a PPRE (PPARγ responsive element) containing reporter cell line,...
Due to the vast differences in chemical properties among small molecule drugs, nucleotide and superparamagnetic iron oxide nanocubes (SPIONs), such as charge hydrophobicity, entrapment of these within a single carrier for traceable synergistic therapy has been proven difficult. Herein, we synthesize positively charged polyprodrug amphiphiles. The hydrophobic unit amphiphiles is charged, which can simultaneously load SPIONs absorb negative let-7b antisense oligonucleotide construct...
Nanoparticles that can efficiently control the differentiation of neural stem cells (NSCs) into neurons are developed for Alzheimer's disease (AD) therapy. The treatment with these nanoparticles results in an attenuation neuronal loss and rescues memory deficiencies mice. system also be used to monitor transplantation site, as well migration NSCs real time. Therefore, is proposed open up new avenues AD treatment. As a service our authors readers, this journal provides supporting information...