A5100456790- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- Dental materials and restorations
- Osteoarthritis Treatment and Mechanisms
- Luminescence Properties of Advanced Materials
- 3D Printing in Biomedical Research
- Nanoplatforms for cancer theranostics
- Lanthanide and Transition Metal Complexes
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Bone and Dental Protein Studies
- Dental Erosion and Treatment
- Periodontal Regeneration and Treatments
- Dental Trauma and Treatments
- biodegradable polymer synthesis and properties
- Mesenchymal stem cell research
- Knee injuries and reconstruction techniques
- Polymer Surface Interaction Studies
- Luminescence and Fluorescent Materials
- Additive Manufacturing and 3D Printing Technologies
- Molecular Junctions and Nanostructures
- Extracellular vesicles in disease
Peking University
2016-2025
The Future University
2025
Faculdade do Futuro
2025
Jiangsu University of Science and Technology
2024
Sichuan University
2009-2023
West China Hospital of Sichuan University
2023
Chongqing University of Arts and Sciences
2022
State Key Laboratory of Biotherapy
2019-2020
Articular cartilage repair remains a great challenge for clinicians and researchers. Recently, there emerges promising way to achieve one-step in situ by combining endogenic bone marrow stem cells (BMSCs) with suitable biomaterials using tissue engineering technique. To meet the increasing demand engineering, structurally functionally optimized scaffold is designed, integrating silk fibroin gelatin combination BMSC-specific-affinity peptide 3D printing (3DP) technology. The ratio of greatly...
New exosome-laden scaffolds shed light on the immune cell activities that benefit tissue repair.
Meniscus deficiency, the most common and refractory disease in human knee joints, often progresses to osteoarthritis (OA) due abnormal biomechanical distribution articular cartilage abrasion. However, its anisotropic spatial architecture, complex microenvironment, limited vascularity, meniscus repair remains a challenge for clinicians researchers worldwide. In this study, we developed 3D printing-based biomimetic composite tissue-engineered scaffold consisting of polycaprolactone (PCL)/silk...
Rare-earth Yb3+ and Ho3+ co-doped fluorapatite (FA:Yb3+/Ho3+) crystals were prepared by hydrothermal synthesis their structure, upconversion properties, cell proliferation imaging investigated. The synthesized crystals, with a size of 16 286 nm, have hexagonal crystal structure classic FA Ca/Yb/Ho molar ratio 100/16/2.1. Several reasonable Yb3+/Ho3+ -embedding lattice models along the fluorine channel are proposed for first time, such as (Ca7YbHo©)(PO4)6F2 (Ca6YbHoNa2)(PO4)6F2. activated...
Notable differences exist between synthetic and native apatite in their crystal size state of existence bone tissue.
Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering, achieving long-term controlled exosome remains significant challenge. Diffusion-dominated release using hydrogels results burst of exosomes. Here, fibroin-based cryo-sponge was developed to provide release. Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature. Exosome is enzyme-responsive,...
Abstract Adhesive tissue engineering scaffolds (ATESs) have emerged as an innovative alternative means, replacing sutures and bioglues, to secure the implants onto target tissues. Relying on their intrinsic adhesion characteristics, ATES systems enable minimally invasive delivery of various scaffolds. This study investigates development first class 3D bioprinted constructs using functionalized hydrogel bioinks. Two strategies, in situ printing adherend versus then transferring surface, are...
Biomaterials have been playing important roles in cartilage regeneration. Although many scaffolds reported to enhance regeneration, none of the available are optimal regarding mechanical properties, integration with host and providing proper micro-environment for chondrocyte attachment, proliferation differentiation. In current study, chitosan-modified poly(L-lactide-co-ε-caprolactone) (PLCL) were fabricated simulate main biochemical components cartilage, as well their interaction aim endow...
Hydrogels are attractive for cartilage tissue engineering because of their high plasticity and similarity with the native matrix. However, one critical drawback hydrogels osteochondral repair is inadequate mechanical strength. To address this limitation, we constructed a solid-supported thermogel comprising chitosan hydrogel system demineralized bone Scanning electron microscopy, equilibrium scanning ratio, biodegradation rate, biomechanical tests, biochemical assays, metabolic activity...
Silk fibroin (SF) is a natural polymer with low immunogenicity and good biocompatibility. However, most silk-based hydrogels formed through chemical or physical cross-linking are brittle, the preparation of which also inevitably introduces cytotoxic agents. Herein, simple strategy presented for synthesizing SF tunable mechanical properties by combining γ-ray radiation ethanol treatment. Neither toxic initiators nor agents utilized during whole procedure. For "soft" hydrogels, compressive...
The combination of photothermal therapy with chemotherapy has gradually developed into promising cancer therapy. Here, a synergistic photothermal-chemotherapy nanoplatform based on polydopamine (PDA)-coated gold nanoparticles (AuNPs) were facilely achieved via the in situ polymerization dopamine (DA) surface AuNPs. This exhibited augmented conversion efficiency and enhanced colloidal stability comparison uncoated PDA shell i-motif DNA nanostructure was assembled PDA-coated AuNPs, which could...
Regenerating the microstructure of human tooth enamel under near-physiological conditions (pH 6.0, 37 degrees C, 1 atm) using a simple chemical approach demonstrates potential application to repair damage in dental clinics.
A bonding confinement strategy was used to anchor FePc molecules on a pre-synthesized Fe–N–C material with axially coordinated O-FeN 4 sites. The sites can improve charge transfer and promote ORR activity.
The exploration of bone reconstruction with time requires the combination a biological method and chemical technique. Lanthanide Yb3+ Ho3+ co-doped fluorapatite (FA:Yb3+/Ho3+) hydroxyapatite (HA:Yb3+/Ho3+) particles varying dopant concentrations were prepared by hydrothermal synthesis thermal activation. Controllable green red upconversion emissions generated under 980 nm near-infrared excitation; FA:Yb3+/Ho3+ resulted in superior luminescence, while HA:Yb3+/Ho3+ dominated emission....
Poly(lactic acid) (PLA) stereocomplex crystallite (SC)-based electrospun nanofibers were fabricated via annealing the as-spun membranes at 100 °C for 1 h. The heat-treated exhibit enhanced mechanical properties and thermal resistance due to existence of SCs, which restricts lactide chain mobility. formation SCs increases intermolecular forces between l-lactide d-lactide segments, resulting in almost 2 times higher tensile strength (8.52 ± 0.29 MPa) 3 Young's modulus (285.48 1.19 than that...
Adipose-derived stem cells (ADSCs) are known to promote angiogenesis and adipogenesis. However, their limited ability efficiently target integrate into specific tissues poses a major challenge for ADSC-based therapies. In this study, we identified seven-amino acid peptide sequence (P7) with high specificity ADSCs using phage display technology. P7 was then covalently conjugated decellularized adipose-derived matrix (DAM), creating an "ADSC homing device" designed recruit both in vitro vivo....
Alginate is a negative ionic polysaccharide that found abundantly in nature. Calcium usually used as cross‐linker for alginate. However, calcium cross‐linked alginate only vitro culture. In the present work, was modified with glycidyl methacrylate (GMA) to produce thermal polymerizable alginate‐GMA (AA‐GMA) macromonomer. The molecular structure and methacrylation (%DM) of macromonomer were determined by 1 H NMR. After mixing correct amount initiator, AA‐GMA aqueous solution can be...
Abstract Hierarchical surface roughness of titanium and alloy implants plays an important role in osseointegration. In vitro vivo studies show greater osteoblast differentiation bone formation when have submicron‐scale textured surfaces. this study, we tested the potential benefit combining a with three‐dimensional (3D) structure on involvement integrin‐driven mechanism. 3D scaffolds were made using orderly oriented meshes microroughness was added to wire by acid‐etching. MG63 human...