A5015625492- Bone Tissue Engineering Materials
- Advanced Photocatalysis Techniques
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Plant Stress Responses and Tolerance
- Plant tissue culture and regeneration
- Covalent Organic Framework Applications
- Nanoplatforms for cancer theranostics
- Tissue Engineering and Regenerative Medicine
- Plant nutrient uptake and metabolism
- Plant-Microbe Interactions and Immunity
- Potato Plant Research
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Plant Virus Research Studies
- Flowering Plant Growth and Cultivation
- Forest, Soil, and Plant Ecology in China
- Bone fractures and treatments
- Perovskite Materials and Applications
- Osteoarthritis Treatment and Mechanisms
- Gas Sensing Nanomaterials and Sensors
- Light effects on plants
- Periodontal Regeneration and Treatments
- Forest Biomass Utilization and Management
- Carbon and Quantum Dots Applications
Stanford University
2021-2025
Changzhou No.2 People's Hospital
2022-2024
Nanjing Medical University
2022-2024
Hebei GEO University
2024
Second Affiliated Hospital of Nanjing Medical University
2023
Sichuan Agricultural University
2010-2022
Peking University
2016-2021
Ten Chen Hospital
1999
While the studies on material interaction with mesenchymal stem cells (MSCs) have been mainly focused ability of materials to provide environment regulate cell viability, proliferation or differentiation, therapeutic effects MSC-material constructs may result from secretion immunomodulatory and angiogenic cytokines MSCs. Here, electrospun scaffolds composed fibers in random, aligned mesh-like patterns were fabricated, paracrine behavior adipose-derived MSCs (Ad-MSCs) investigated comparison...
New exosome-laden scaffolds shed light on the immune cell activities that benefit tissue repair.
Abstract Naturally‐derived cell membranes have shown great promise in functionalizing nanoparticles to enhance biointerfacing functions for drug delivery applications. However, its potential macroporous scaffolds tissue regeneration vivo remains unexplored. Engineering with immunomodulatory represents an exciting strategy but is largely limited soft tissues. Critical‐sized bone defects cannot heal on their own, and the role of adaptive immune cells scaffold‐mediated healing cranial unknown....
Potato tuber dormancy is critical for the post-harvest quality. Snakin/Gibberellic Acid Stimulated in Arabidopsis (GASA) family genes are involved plants’ defense against pathogens and growth development, but effect of Snakin-2 (SN2) on sprouting largely unknown. In this study, a transgenic approach was applied to manipulate expression level SN2 tubers, it demonstrated that StSN2 significantly controlled sprouting, silencing resulted release overexpressing tubers showed longer dormant period...
Biomaterial-immune system interactions play an important role in postimplantation osseointegration to retain the functionality of healthy and intact bones. Therefore, appropriate osteoimmunomodulation implants has been considered validated as efficient strategy alleviate inflammation enhance new bone formation. Here, we fabricated a nanostructured PCL/PVP (polycaprolactone/polyvinylpyrrolidone) electrospinning scaffold for cell adhesion, tissue ingrowth, defect padding. In addition,...
Abstract Conventional electrospinning produces nanofibers with smooth surfaces that limit biomineralization ability. To overcome this disadvantage, we fabricated a tetramethylpyrazine (TMP)-loaded matrix-mimicking in PCL/Gelatin composite electrospun membranes bubble-shaped nanofibrous structures. (PG), containing biomineralized hydroxyapatite (HA) (PGH), and HA loaded TMP (PGHT) were tested. In vitro results indicated the surface increased roughness of promoted mineralization. Furthermore,...
The dry root and rhizome of Salvia miltiorrhiza are used to treat cardiovascular diseases, chronic pain, thoracic obstruction over 2000 years in Asian countries. For high quality, Sichuan Zhongjiang is regarded as the genuine producing area S. miltiorrhiza. Given its abnormal pollen development, from (S.m.-SC) relies on reproduction zymad accumulation; part diseased plants present typical viral disease symptoms seed quality degeneration. This study aim detected unknown viruses...
Tissue-derived extracellular matrix (tdECM) hydrogels serve as effective scaffolds for tissue regeneration by promoting a regenerative immune response. While most tdECM are nanoporous and tailored soft tissue, macroporosity is crucial bone regeneration. Yet, there's shortage of macroporous ECM-based this purpose. The study aims to address gap developing co-spinning technique integrate bone-derived ECM (bECM) into gelatin-based, microribbon (µRB) scaffolds. effect varying doses bECM on...
Hydroxyapatite (HA) is a promising scaffold material for the treatment of bone defects. However, lack angiogenic properties and undesirable mechanical (such as fragility) limits application HA. Nanoattapulgite (ATP) nature-derived clay mineral has been proven to be bioactive regeneration due its ability induce osteogenesis. In this study, polyvinyl alcohol/collagen/ATP/HA (PVA/COL/ATP/HA) scaffolds were printed. Mouse marrow mesenchymal stem/stromal cells (BMSCs) human umbilical vein...
Osteogenesis is caused by multiple factors, and the inflammatory response, osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), regeneration blood vessels, other factors must be considered in tissue engineering. To effectively repair defect, it important to decrease excessive inflammation, enhance into osteoblasts, stimulate angiogenesis. Herein, nano-attapulgite (ATP), polyvinyl alcohol (PVA), gelatin (GEL) scaffolds were produced using 3D printing technology...
Abstract The potato tuber is the main nutrient supply and reproductive organ; however, sprouting can reduce its commercial value. Snakin-2 (StSN2) was first reported as an antimicrobial peptide that positively regulates disease resistance. Our recent study suggested StSN2 overexpression inhibited sprout growth, while process accelerated in RNAi lines. Cytoplasmic glyceraldehyde-3-phosphate dehydrogenase 1 (StGAPC1) identified a candidate protein interacts with co-immunoprecipitation/mass...
Rationale: Mineral particles have been widely used in bone tissue engineering scaffolds due to their osteoconductive and osteoinductive properties.Despite benefits, mineral can induce undesirable inflammation subsequent resorption.Aspirin (Asp) is an inexpensive anti-inflammatory drug.The goal of this study assess the synergistic effect Asp optimized particle coating macroporous accelerate endogenous regeneration reduce resorption a critical-sized defect model.Methods: Four commonly with...
The macronutrient potassium is essential to plant growth, development and stress response. Alligator weed (Alternanthera philoxeroides) has a high tolerance deficiency (LK) stress. stem the primary organ responsible for transporting molecules from underground root system aboveground parts of plant. However, proteomic changes in response LK are largely unknown alligator stems. In this study, we investigated physiological stems under First, chlorophyll soluble protein content SOD POD activity...
A critical size bone defect is a clinical scenario in which lost or excised due to trauma, infection, tumor, other causes, and cannot completely heal spontaneously. The most common treatment for this condition autologous grafting the site. However, graft often insufficient quantity quality transplantation these large defects. Recently, tissue engineering methods using mesenchymal stem cells (MSCs) have been proposed as an alternative treatment. underlying biological principles optimal...