A5044496685- Bone and Joint Diseases
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Mesenchymal stem cell research
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- RNA and protein synthesis mechanisms
- Heavy Metal Exposure and Toxicity
- Bone Metabolism and Diseases
- Bone health and treatments
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Tissue Engineering and Regenerative Medicine
- Bone health and osteoporosis research
- Extracellular vesicles in disease
- Microstructure and Mechanical Properties of Steels
- Carcinogens and Genotoxicity Assessment
- Occupational exposure and asthma
- Gastrointestinal disorders and treatments
- Periodontal Regeneration and Treatments
- Spinal Cord Injury Research
- Toxic Organic Pollutants Impact
- Pelvic and Acetabular Injuries
- Radiation Dose and Imaging
Kyushu University
2015-2025
Stanford University
2020-2024
Orthopaedic Research Laboratories
2021
Nisshin Steel (Japan)
1986-1987
University of Connecticut
1966
Background: The incidence of developmental dysplasia the hip (DDH) in Japanese newborns has reduced drastically following a primary prevention campaign initiated around 1972 to 1973; this perinatal education promoted maintaining hips naturally flexed-leg position. purpose present study was describe life course epidemiology osteoarthritis (OA) adolescent and adult patients assess its association with exposure for DDH. Methods: We included new OA diagnosed from January 1, 2022, December 31, at...
The Confocal Endomicroscopy System (Optiscan Pty Ltd. and Pentax Corp.) is a newly developed imaging tool that uses laser light optical technology to visualize living tissue at the cellular level. Digital images of cells magnified 1000-fold appear in real time on computer screen, which enables immediate detection changes structure without need for biopsy. aim this study was assess features architecture cancerous can be used differential diagnosis normal mucosa using system's image-processing...
Abstract Background Mesenchymal stem cell (MSC)-based therapy has the potential for immunomodulation and enhancement of tissue regeneration. Genetically modified MSCs that over-express specific cytokines, growth factors, or chemokines have shown great promise in pre-clinical studies. In this regard, anti-inflammatory cytokine interleukin (IL)-4 converts pro-inflammatory M1 macrophages into an M2 phenotype; mitigate chronic inflammation enhance osteogenesis by MSC lineage cells. However,...
Stress distribution remains unclear in early-stage osteonecrosis of the femoral head (ONFH). To clarify this issue, we generated patient-specific finite element models (FEMs) from 51 patients with ONFH. Patients' hips were classified into three groups: ONFH without a sclerotic boundary (Stage 1, n = 6), 2, 10), and both <2 mm collapse 3, 35). Four used as controls. each FEM was compared magnetic resonance imaging (MRI) computed tomography (CT) results. Fifteen wholly resected heads Stage 3...
Mesenchymal stem cell (MSC)-based therapy is a promising strategy for bone repair. Furthermore, the innate immune system, and specifically macrophages, plays crucial role in differentiation activation of MSCs. The anti-inflammatory cytokine Interleukin-4 (IL-4) converts pro-inflammatory M1 macrophages into tissue regenerative M2 phenotype, which enhances MSC function. We developed lentivirus-transduced IL-4 overexpressing MSCs (IL-4 MSCs) that continuously produce polarize toward an...
Approximately one third of patients undergoing core decompression (CD) for early-stage osteonecrosis the femoral head (ONFH) experience progression disease, and subsequently require total hip arthroplasty (THA). Thus, identifying adjunctive treatments to optimize bone regeneration during CD is an unmet clinical need. Platelet-derived growth factor (PDGF)-BB plays a central role in cell differentiation. The aim this study was characterize mesenchymal stromal cells (MSCs) that were genetically...
Aims Transcription factor nuclear kappa B (NF-κB) plays a major role in the pathogenesis of chronic inflammatory diseases all organ systems. Despite its importance, NF-κB targeted drug therapy to mitigate inflammation has had limited success preclinical studies. We hypothesized that sex differences affect response treatment during bone. This study investigated therapeutic effects decoy oligodeoxynucleotides (ODN) male and female mice. Methods used murine model induced by continuous...
<title>Abstract</title> <bold>Background:</bold> Few reports have focused on major perioperative complications, including periprosthetic femoral fracture (PFF) and stem subsidence in cementless total hip arthroplasty (THA), after standardizing the patient’s background comparing different component design at a single center. Therefore, this study aimed to compare incidence of PFF patients undergoing THA between two types component. <bold>Methods:</bold> Between January 2013 June 2020, 753...
This study aimed to investigate whether the use of CT-based navigation enhances: 1) accuracy cup placement; and 2) achievement rate required range motion (ROM). Additionally, we investigated impact using a large femoral head dual-mobility liner on rates. retrospective analyzed 60 manual 51 navigated primary total hip arthroplasties performed at single facility. Postoperative CT scans simulation software were employed measure orientation simulate ROM. We compared absolute errors for...
ABSTRACT The reparative zone in femoral head osteonecrosis is pivotal for repair; however, the repair response mechanism remains poorly understood. Although neurotrophic nerve growth factor significantly contributes to bone formation fatigue fractures and ectopic ossification, relationship between unexplored. We aimed elucidate role of repair. Twenty‐seven wholly resected heads diagnosed with Japanese Investigation Committee Stage 3 osteonecrosis, excluding those severe collapse, were...
Background: Spinopelvic abnormalities have been reported to be a risk factor for dislocation after total hip arthroplasty (THA). This study aimed compare the kinematics of pelvis and joints in patients with without spinopelvic THA elucidate dynamic forward-leaning movement during chair-rising, which are not detectable through static radiographs. Methods: case series included 108 hips that underwent anteroposterior radiographic imaging sit-to-stand motion THA. The average age at surgery was...
PURPOSE: To describe the endoscopic ultrasound (US) features of benign versus malignant submucosal tumors throughout gastrointestinal tract. MATERIALS AND METHODS: One hundred nine patients aged 24-81 years suspected to have (11 esophageal, 41 stomach, 24 duodenal, and 33 colorectal tumors) at barium studies or endoscopy underwent US. The layer origin, internal echo pattern, lesion margin were analyzed by means consensus independent interpretation three radiologists. RESULTS: Endoscopic US...
Background/Objective: Core decompression (CD) with scaffold and cell-based therapies is a promising strategy for providing both mechanical support regeneration of the osteonecrotic area early stage osteonecrosis femoral head (ONFH). We designed new 3D printed porous functionally-graded (FGS) central channel to facilitate delivery transplanted cells in hydrogel area. However, optimal structural design FGS engineering bone ONFH has not been elucidated. The aim this study was fabricate evaluate...
The RNase activity and properties of ribosome polysome preparations from normal rat liver some hepatomas have been examined. Polysome the Novikoff, McCoy MDAB, Dunning had considerably higher specific than corresponding liver, Novikoff ascites, or Morris 5123 hepatomas. optimum pH was approximately 8.5 for all samples tested, showed no evidence latent when treated with 3 M sodium chloride, EDTA, urea, p-chloromercuribenzenesulfonic acid. appeared to be associated principally breakdown...
Wear particle-associated bone loss (periprosthetic osteolysis) constrains the longevity of total joint arthroplasty (TJA). particles induce a prolonged upregulation nuclear factor kappa B (NF-κB) signaling in macrophages and osteoclasts. Synthetic double-stranded oligodeoxynucleotides (ODNs) can prevent binding NF-κB to promoter regions targeted genes inhibit genetic activation. We tested hypothesis that polyethylene-particle induced chronic inflammatory could be suppressed by local delivery...
Wear debris generated from the bearing surfaces of joint arthroplasties leads to acute and chronic inflammation, which is strongly associated with implant failure. Macrophages derived monocytes recruited local tissues have a significant impact on bone healing regeneration. can adopt various functional phenotypes. While M1 macrophages are pro-inflammatory, M2 express factors important for tissue repair. Here, we established 3D co-culture system investigate how immune influences osteogenic...
A critical size bone defect is a clinical scenario in which lost or excised due to trauma, infection, tumor, other causes, and cannot completely heal spontaneously. The most common treatment for this condition autologous grafting the site. However, graft often insufficient quantity quality transplantation these large defects. Recently, tissue engineering methods using mesenchymal stem cells (MSCs) have been proposed as an alternative treatment. underlying biological principles optimal...