A5088563966- Shoulder Injury and Treatment
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Surgery and Rehabilitation
- Hip disorders and treatments
- Bone fractures and treatments
- Sports injuries and prevention
- Shoulder and Clavicle Injuries
- Lower Extremity Biomechanics and Pathologies
- Tendon Structure and Treatment
- Elbow and Forearm Trauma Treatment
- Bone and Joint Diseases
- Nerve Injury and Rehabilitation
- Foot and Ankle Surgery
- Hip and Femur Fractures
- Mesenchymal stem cell research
- Cardiac Valve Diseases and Treatments
- Orthopedic Infections and Treatments
- Bone health and treatments
- Adhesion, Friction, and Surface Interactions
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Sports Performance and Training
- Trauma Management and Diagnosis
Stanford University
2019-2024
Steadman Philippon Research Institute
2018-2022
Globus Medical (United States)
2020
Stanford Medicine
2020
Twin Cities Orthopedics
2020
Lexington Clinic
2020
Previous work has reported that increased tibial slope is directly correlated with anterior translation, possibly predisposing patients to higher rates of cruciate ligament (ACL) tears and causing ACL graft failures over the long term. However, effect changes in sagittal plane on reconstruction (ACLR) force not been well defined.The purpose this study was quantify ACLR at varying knee flexion angles. Our null hypothesis changing would affect graft.Controlled laboratory study.Ten male...
Background: Meniscal ramp lesions have been defined as a tear of the peripheral attachment posterior horn medial meniscus (PHMM) at meniscocapsular junction or an injury to meniscotibial attachment. Precise anatomic descriptions these structures are limited in current literature. Purpose: To quantitatively and qualitatively describe PHMM posteromedial capsule anatomy pertaining location meniscal lesion with reference surgically relevant landmarks. Study Design: Descriptive laboratory study....
Background: Although posterior medial meniscal root (PMMR) repairs are often successful, postoperative extrusion after a repair has been identified as potential clinical problem. Purpose/Hypothesis: The purpose was to quantitatively evaluate the tibiofemoral contact mechanics and extent of PMMR repair. It hypothesized that addition centralization suture (into tibial plateau) would help restore normal joint load-bearing characteristics native amount tear. Furthermore, we be greatest in loaded...
Background: A flattened posterior tibial slope may cause excessive unwanted stress on the cruciate ligament (PCL) reconstruction graft and place patients at risk for PCL failure. To date, there is a paucity of biomechanical studies evaluating effect loading properties single-bundle (SB) double-bundle (DB) grafts. Purpose/Hypothesis: The purpose this study was to quantify sagittal plane force varying slopes knee flexion angles SB DB reconstructions. null hypothesis that would be no...
Metal screws are traditionally used to fix the coracoid process glenoid. Despite stable fixation, metal have been associated with hardware complications. Therefore, some studies advocated for suture button fixation during Latarjet procedure reduce complications screw fixation.To biomechanically evaluate ultimate failure load of a cortical and self-tensioning versus graft procedure.Controlled laboratory study.Eight matched pairs fresh-frozen, male cadaveric shoulders (N = 16) underwent...
Quantification of the biomechanical properties each individual medial patellar ligament will facilitate an understanding injury patterns and enhance anatomic reconstruction techniques by improving selection grafts possessing appropriate for ligament.To determine ultimate failure load, stiffness, mechanism patellofemoral (MPFL), patellotibial (MPTL), patellomeniscal (MPML) to assist with graft tissue reconstructions.Descriptive laboratory study.Twenty-two nonpaired, fresh-frozen cadaveric...
Background: Surgical treatment of lateral meniscal tears can be challenging due to the greater mobility meniscus, thin capsule, and management popliteal hiatus. There has been a lack quantitative assessments structural attachments posterior horn meniscus (PHLM) guide repairs. Purpose: To qualitatively quantitatively describe anatomy PHLM, popliteomeniscal fascicles, posterolateral capsule. Study Design: Descriptive laboratory study. Methods: Fourteen male, nonpaired, fresh-frozen cadaveric...
Background: The acetabular labrum has been found to provide a significant contribution the distractive stability of hip. However, influence labral height on hip suction seal biomechanics is not known. Hypothesis: smaller associated with decreased stability. Study Design: Descriptive laboratory study. Methods: A total 23 fresh-frozen cadaveric hemipelvises were used in this Hips dysplasia or femoroacetabular impingement–related bony morphologic features, intra-articular pathology, no...
Background: Increased posterior tibial slope and medial meniscus root tears increase the force experienced by anterior cruciate ligament (ACL) predispose patients to higher rates of primary ACL injury or graft failure after an reconstruction (ACLR). However, interplay among sagittal plane slope, tears, ACLR remains inadequately defined. Purpose/Hypothesis: The purpose was quantify effect on at varying knee flexion angles with intact meniscus, a tear, repair. Our null hypothesis that changes...
Background: The capsular ligaments and the labral suction seal cooperatively manage distractive stability of hip. Capsular reconstruction using an iliotibial band (ITB) allograft aims to address insufficiency iatrogenic instability. However, extent which this procedure may restore hip after a defect is unknown. Purpose: To evaluate biomechanical effects on joint. Study Design: Controlled laboratory study. Methods: Eight fresh-frozen cadaveric specimens were dissected level capsule axially...
Background: Historically, radial meniscal tears were treated with partial or near-total meniscectomy, which usually resulted in poor outcomes. Radial function similar to a total meniscectomy and are challenging treat. Repair of should be performed prevent joint deterioration the need for salvage procedures future. Purpose/Hypothesis: The purpose was compare 3 repair techniques medial meniscus: 2-tunnel, hybrid, hybrid tunnel techniques. It hypothesized that there would no differences among...
Background: The acetabular labrum contains free nerve endings, and an unstable can result in increased femoral head movement during hip motion. This be caused by chondrolabral junction (CLJ) separation, especially association with pincer-type femoroacetabular impingement, may contribute to pain. Hypothesis: Rim resection alone has no effect on suction seal biomechanics. Further, separation of the CLJ changes biomechanics when compared those native state, whereas repair refixation suture...
Approximately one third of patients undergoing core decompression (CD) for early-stage osteonecrosis the femoral head (ONFH) experience progression disease, and subsequently require total hip arthroplasty (THA). Thus, identifying adjunctive treatments to optimize bone regeneration during CD is an unmet clinical need. Platelet-derived growth factor (PDGF)-BB plays a central role in cell differentiation. The aim this study was characterize mesenchymal stromal cells (MSCs) that were genetically...
Background/Objective: Core decompression (CD) with scaffold and cell-based therapies is a promising strategy for providing both mechanical support regeneration of the osteonecrotic area early stage osteonecrosis femoral head (ONFH). We designed new 3D printed porous functionally-graded (FGS) central channel to facilitate delivery transplanted cells in hydrogel area. However, optimal structural design FGS engineering bone ONFH has not been elucidated. The aim this study was fabricate evaluate...
Limited biomechanical data exist for dual small plate fixation of midshaft clavicle fractures, and no prior study has concurrently compared plating to larger superior or anteroinferior single screw constructs.To biomechanically compare orthogonal plating, fractures by use a cadaveric model.Descriptive laboratory study.The used 18 specimens (9 pairs total), 3 techniques were studied: anteroinferior, superior, dual. The technique smaller diameter plates screws (1.6-mm thickness) than the...
Transtibial pull-out repair of the medial meniscal posterior root (MMPR) has been largely assessed through biomechanical studies. Biomechanically comparing different suture types would further optimize MMPR fixation and affect clinical care.The purpose this study was to determine optimal material for fixation. It hypothesized that ultra high-molecular weight polyethylene (UHMWPE) tape be biomechanically superior UHMWPE standard suture.Controlled laboratory study.The attachment divided in 24...
Injuries of the bone-to-tendon interface, such as rotator cuff and anterior cruciate ligament tears, are prevalent musculoskeletal injuries, yet effective methods for repair remain elusive. Tissue engineering approaches that use cells biomaterials offer a promising potential solution bone–tendon but previous strategies require seeding multiple cell types multiphasic scaffolds to achieve zonal-specific tissue phenotype. Furthermore, mimicking aligned morphology present in native interface...
Adult skeletal stem cells (SSCs) that give rise to chondrocytes, osteocytes, and stromal as progeny have been shown contribute cartilage regeneration in osteoarthritis (OA). Understanding extrinsic intrinsic regulators of SSC fate function can therefore identify putative candidate factors enhance regeneration. This study explores how the DNA hydroxymethylase Tet1 regulates OA.
Abstract Core decompression (CD) with mesenchymal stromal cells (MSCs) is an effective therapy for early‐stage osteonecrosis of the femoral head (ONFH). Preconditioning MSCs, using inflammatory mediators, widely used in immunology and various cell therapies. We developed a three‐dimensional printed functionally graded scaffold (FGS), made β‐TCP PCL, delivery at specific location. The present study examined efficacy CD treatments genetically modified (GM) MSCs over‐expressing PDGF‐BB...
Meniscus root tears are associated with chondral injury, early degenerative change, and a high conversion rate to total knee arthroplasty. It is well-established that meniscus lead decreased femorotibial contact area, increased peak pressures, stress on the articular cartilage.To evaluate biomechanical characteristics of all-inside repair procedure compare it previously described transtibial technique.Controlled laboratory study.Nine paired cadaveric knees were prepared by removing skin,...
Background: Given the variety of suturing techniques for bucket-handle meniscal repair, it is important to assess which technique best restores native biomechanics. Purpose/Hypothesis: To biomechanically compare vertical mattress and cross-stitch suture techniques, in single- double-row configurations, their ability restore knee kinematics a medial tear model. The hypothesis was that there would be no difference between but provide significantly improved biomechanical parameters versus...
Bone marrow-derived mesenchymal stem cells (BMSCs) have potential to accelerate flexor tendon healing and allow for earlier rehabilitation. The ideal BMSC construct delivery method the repair site remains unknown. We investigated efficacy of interposed scaffold-free sheets on early Achilles in rats. BMSCs were isolated from femora tibias male Sprague-Dawley rats aged 8-12 weeks produced temperature-responsive culture dishes. Ninety-five utilized. A bilateral model was created. One side...