A5005311244- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Pelvic and Acetabular Injuries
- Mesenchymal stem cell research
- Management of metastatic bone disease
- Bone Metabolism and Diseases
- Infectious Diseases and Tuberculosis
- Hip disorders and treatments
- Bone and Joint Diseases
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Musculoskeletal Disorders and Rehabilitation
- Bone fractures and treatments
- Diversity and Career in Medicine
- Hip and Femur Fractures
- Spinal Hematomas and Complications
- Bone health and treatments
- Bone health and osteoporosis research
- Shoulder Injury and Treatment
- Case Reports on Hematomas
- Trauma Management and Diagnosis
Saga University
2018-2024
Stanford University
2021-2024
Weatherford College
2024
Khon Kaen University
2024
Soka Municipal Hospital
2024
Hokushin General Hospital
2024
Chiba University
2024
Obayashi (Japan)
2024
University of Yamanashi
2024
Fukushima Medical University
2024
Despite the recent advances in cancer treatment, incidence of patients with spinal metastases continues to grow along total number patients. Spinal can significantly impair activities daily living (ADL) and quality life (QOL), compared other types bone metastases, as they are characterized severe pain paralysis caused by skeletal-related events. Reduced ADL also lead treatment limitations certain anticancer agents radiation therapy not compatible treatments; thus, leading a shorter...
Aims Transcription factor nuclear kappa B (NF-κB) plays a major role in the pathogenesis of chronic inflammatory diseases all organ systems. Despite its importance, NF-κB targeted drug therapy to mitigate inflammation has had limited success preclinical studies. We hypothesized that sex differences affect response treatment during bone. This study investigated therapeutic effects decoy oligodeoxynucleotides (ODN) male and female mice. Methods used murine model induced by continuous...
Despite the high incidence of fractures and pseudoarthrosis in aged population, a potential role for use mesenchymal stem cells (MSCs) treatment bone defects elderly patients has not been elucidated. Inflammation innate immune system, including macrophages, play crucial roles differentiation activation MSCs. We have developed lentivirus-transduced interleukin 4 (IL4) over-expressing MSCs (IL4-MSCs) to polarize macrophages an M2 phenotype promote healing established young murine critical size...
The concept of minimally invasive spine therapy (MIST) has been proposed as a treatment strategy to reduce the need for overall patient care, including not only surgery (MISS) but also conservative and rehabilitation. To maximize effectiveness care in surgery, educational needs medical students, residents, rehabilitation can be enhanced by digital transformation (DX), virtual reality (VR), augmented (AR), mixed (MR), extended (XR), three-dimensional (3D) images holograms; wearable sensors,...
The phrase “skin as a mirror of internal medicine,” which means that the skin reflects many diseases organs, is well-known notion. Despite phenotypic differences between soft and hard bone, bone are highly associated. Skin consist fibroblasts osteoblasts, respectively, secrete collagen involved in synthesis, while Langerhans cells osteoclasts control turnover. Moreover, quality quantity may be modified by aging, inflammation, estrogen, diabetes, glucocorticoids. pathologically drugs,...
Abstract Background Continuous cross talk between MSCs and macrophages is integral to acute chronic inflammation resulting from contaminated polyethylene particles (cPE); however, the effect of this inflammatory microenvironment on mitochondrial metabolism has not been fully elucidated. We hypothesized that (a) exposure cPE leads impaired glycolytic reprogramming (b) play a key role in pathway. Methods cultured with/without uncommitted M0 macrophages, 3-dimensional gelatin methacrylate (3D...
Staphylococcus aureus is a main pathogen of osteomyelitis and protein A virulence factor with high affinity for IgG. In this study, we investigated whether S. affects the differentiation bone resorption osteoclasts through IgG-binding capacity A. pre-treated serum or IgG showed marked enhancement in osteoclastogenesis compared to non-treated A-deficient mutant. Blocking Fc receptor deletion Fcγ gene osteoclast precursor cells that enhanced stimulated by immune complexes (ICs) was mediated on...
Abstract Core decompression (CD) with mesenchymal stromal cells (MSCs) is an effective therapy for early‐stage osteonecrosis of the femoral head (ONFH). Preconditioning MSCs, using inflammatory mediators, widely used in immunology and various cell therapies. We developed a three‐dimensional printed functionally graded scaffold (FGS), made β‐TCP PCL, delivery at specific location. The present study examined efficacy CD treatments genetically modified (GM) MSCs over‐expressing PDGF‐BB...
Many cases of vertebral osteomyelitis (VO) and infective endocarditis (IE) co-infection have been reported, it has recognized that attention should be paid to the possibility both diseases co-existing during diagnosis treatment. However, incidence, clinical status, outcomes IE in patients with VO remain unclear. For this study, eligibility criteria for patient recruitment included all at five medical university hospitals. Patients a history spinal surgery were excluded from study....
Osteoclasts derived from hematopoietic cells are activated on bone surface. To resorb bone, osteoclasts release acid and lysosome hydrolase via membrane transport. Prostate transmembrane protein androgen induced 1 (Pmepa1) is a type I that regulates proliferation, migration, metastasis of cancer cells. Because recent reports showed Pmepa1 involved in transport cells, we investigated the role osteoclast function. expression was barely detected formed plastic surfaces vitro, but markedly...
There are no reports that have examined the annual trends of percentage women who members Japanese Society for Spine Surgery and Related Research (JSSR) or their roles at meetings. Furthermore, status gender diversity in JSSR remains unclear. This study aims to identify by quantifying role meetings over past decade.
Fixed abduction and/or adduction deformities of the hip joint may cause pelvic obliquity with subsequent development secondary lumbar scoliosis. However, relationships between magnitude a fixed angle (either or adduction) and direction tilt scoliosis remain unclear. The purpose this study was to investigate coronal alignment spine pelvis in patients ankylosed hips.A total 56 were analyzed, including 17 males 39 females, an average age 65 years (range: 45 80 years). Regarding spinopelvic...
Nuclear protein 1 (NUPR1) is a multifunctional stress-induced involved in regulating tumorigenesis, apoptosis, and autophagy. Bone homeostasis maintained by bone-resorbing osteoclasts bone-forming osteoblasts osteocytes. We aimed to determine the role of NUPR1 bone metabolism. Using microcomputed tomography, we found that mice lacking Nupr1 exhibited increased volume. Histologic analysis showed deficiency decreased osteoclast numbers but osteoblast osteoid formation. In vitro culture marrow...
Mesenchymal stem cell (MSC)-based therapy and novel biomaterials are promising strategies for healing of long bone critical size defects. Interleukin-4 (IL-4) over-expressing MSCs within a gelatin microribbon (µRB) scaffold was previously shown to enhance the bridging femoral defect in male Balb/c mice. Whether sex differences affect this conjunction with different treatments is unknown. In study, we generated 2-mm critical-sized diaphyseal defects 10-12-week-old female Scaffolds without...
To elucidate the changes in coronal lumbar-pelvic-femoral alignment after conversion total hip arthroplasty (THA) patients with unilateral ankylosed hip. A retrospective radiologic study of 48 (48 hips) arthrodesis who underwent THA was conducted. Cobb's angle lumbar scoliosis (LS), pelvic obliquity (PO) angle, and adduction (HAA) on standing anterior-posterior spine-pelvis-hip radiographs were measured before THA. The differences LS, PO, HAA defined as ΔLS, ΔPO, ΔHAA, respectively. paired...