A5014643091- Asthma and respiratory diseases
- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Fibrosis and Remodeling
- Occupational exposure and asthma
- Respiratory and Cough-Related Research
- Receptor Mechanisms and Signaling
- Autoimmune Bullous Skin Diseases
- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Cell Adhesion Molecules Research
- Cholesterol and Lipid Metabolism
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Contact Dermatitis and Allergies
- Sphingolipid Metabolism and Signaling
- Psoriasis: Treatment and Pathogenesis
- Sarcoidosis and Beryllium Toxicity Research
Saga Medical School Hospital
2016-2025
Saga University
2021-2024
Kyushu University
2019
Toho University
2019
Nihon University
2008-2017
International AIDS Vaccine Initiative
2010
Advanced Medical Research Institute
2009-2010
Max Planck Society
2005
Max Planck Institute for Extraterrestrial Physics
2005
Tokai University
2000-2003
Abstract The development of animal models that mimic human allergic responses is crucial to study the pathophysiology disease and generate new therapeutic methodologies. Humanized mice reconstituted with immune systems are essential reactions in vivo expected be useful for studying allergies. However, application this technology allergies has been limited, largely because poor myeloid cells, especially granulocytes mast which responsible mediating diseases, conventional humanized mice. In...
Barrier dysfunction is an important feature of atopic dermatitis (AD) in which IL-4 and IL-13, signature type 2 cytokines, are involved. Periostin, a matricellular protein induced by or plays crucial role the onset allergic skin inflammation, including barrier dysfunction. However, it remains elusive how periostin causes downstream IL-13 signal.We systematically identified periostin-dependent expression profile using DNA microarrays. We then investigated whether IL-24 downregulates filaggrin...
Aggregation of the high affinity receptor for IgE (FcepsilonRI) induces activation mast cells. In this study we show that upon low intensity stimulation FcepsilonRI with monomeric IgE, plus anti-IgE, or Ag, Lyn (a Src family kinase) positively regulates degranulation, cytokine production, and survival, whereas works as a negative regulator Ag. Low suppressed kinase activity its association beta subunit, enhanced beta. The latter induced much higher levels phosphorylation Syk than former....
Abstract Earlier studies, including our own, revealed that activation of mast cells is accompanied by production reactive oxygen species (ROS) help to mediate the release inflammatory mediators, histamine and eicosanoids. However, little known about mechanisms ROS production, oxidants produced. In this study we show in both RBL-2H3 cell line bone marrow-derived cells, FcεRI cross-linking stimulates intracellular oxidative burst, hydrogen peroxide (H2O2) as defined with oxidant-sensitive dyes...
Atopic dermatitis (AD) is a chronic relapsing skin disease accompanied by recurrent itching. Although type 2 inflammation dominant in allergic inflammation, it not fully understood how non-type co-exists with or causes We have recently established the FADS mouse, mouse model of AD. In mice, either genetic disruption pharmacological inhibition periostin, downstream molecule inhibits NF-κB activation keratinocytes, leading to downregulating eczema, epidermal hyperplasia, and infiltration...
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized as progressive and irreversible in the interstitium of lung tissues. There still an unmet need to develop novel therapeutic drug for IPF. We have previously demonstrated that periostin, matricellular protein, plays important role pathogenesis fibrosis. However, underlying mechanism how periostin causes remains unclear. In this study, we sought learn whether cross-talk between TGF-β (transforming growth factor-β),...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease with median survival of only three to 5 years. Fibroblast proliferation hallmark IPF as secretion extracellular matrix proteins from fibroblasts. However, it still uncertain how fibroblasts acquire the ability progressively proliferate. Periostin matricellular protein highly expressed in lung tissues patients, playing critical role pathogenesis fibrosis. remains undetermined whether periostin affects fibroblast...
Heating and heat transfer were studied in a two-dimensional crystalline complex plasma at the kinetic level. The lattice was formed of microspheres levitated sheath. One half crystal heated anisotropically to obtain higher temperatures one direction conduction observed real time. It found that longitudinal phonons conduct better than transverse. thermometric conductivity coefficient measured be $53\text{ }\text{ }{\mathrm{mm}}^{2}/\mathrm{s}$ for heating $30\text{ transverse heating. Heat...
Asthma is one of the most common immunological diseases and characterized by airway hyperresponsiveness (AHR), mucus overproduction, eosinophilia. Although mouse models have provided insight into mechanisms which type-2 cytokines induce asthmatic inflammation, differences between rodent human immune systems hamper efforts to improve understanding allergic diseases. In this study, we aim establish a preclinical animal model inflammation using humanized IL-3/GM-CSF or IL-3/GM-CSF/IL-5 Tg...
BackgroundAtopic dermatitis (AD) is a common chronic eczematous skin disease with severe pruritus. Several new therapeutic agents for AD such as dupilumab, an anti–IL-4Rα antibody, have been developed in recent years. We need to predict which agent the best choice each patient, but this remains difficult.ObjectiveOur aim was examine clinical background factors and baseline biomarkers that could achievement of improved outcomes patients treated dupilumab.MethodsA multicenter, prospective...
Remodelling of pulmonary arteries (PA) contributes to the progression hypertension (PH). Periostin, a matricellular protein, has been reported be involved in development PH. We examined role periostin pathogenesis PH using different types experimental
Ulcerative colitis (UC) is a heterogeneous disease composed of different endotypes. It important to develop useful biomarkers for endotyping UC; however, available are insufficient. We have already established that periostin surrogate biomarker type 2 inflammation. In this study, we examined the usefulness as UC and role in its pathogenesis. expression colons patients. next investigated serum patients correlation with eosinophilic infiltration their colons. then whether could predict...
Periostin is an extracellular matrix protein that highly expressed in nasal polyp (NP) tissues patients with chronic rhinosinusitis (CRS). This study investigated the cellular source of periostin sinonasal and mechanism IL-13-induced production epithelial cells. The amount localization mRNA were examined via immunohistochemistry situ hybridization analysis control subjects eosinophilic (ECRS) non-ECRS. expression levels type 2 inflammatory cytokines tissue measured by levels. Normal human...
Hypothiocyanite (OSCN−) serves as a potent innate defense system against microbes in the lungs. OSCN− is generated by catalysis of peroxidases using thiocyanate transported via several anion transporters, including pendrin/SLC26A4 and hydrogen peroxide (H2O2) Duox1 Duox2. We previously demonstrated that expression pendrin, peroxidases, Duox1/Duox2 up-regulated bronchial asthma patients and/or model mice these molecules are important accelerating airway inflammation. However, it remained...
Aggregation of the high affinity receptor for IgE (FcεRI) on mast cells by antigen and complex induces release chemical mediators, leading to acute allergic inflammation. We recently found that 3-O-(2,3-dimethylbutanoyl)-13-O-decanoylingenol (DBDI), purified from Euphorbia kansui L., inhibits degranulation in rat basophilic leukemia 2H3 upon aggregation FcεRI. In present study, we demonstrated DBDI significantly β-hexosaminidase, synthesis eicosanoids, mobilization intracellular Ca2+ bone...
CCAAT/enhancer binding protein alpha (C/EBPα) is a transcription factor that influences immune cell fate and differentiation. However, the effect of C/EBPα on mast cells not fully understood. In this study, we showed suppressed granule formation in increased macrophage inflammatory (MIP)‐2 production from upon bacterial stimulation. These results indicate regulates balance between allergic response innate cells. Furthermore, stimulation with Lactobacillus casei JCM1134 T strain during late...