A5101460463- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Xenotransplantation and immune response
- Dermatologic Treatments and Research
- Animal Genetics and Reproduction
- IL-33, ST2, and ILC Pathways
- Collagen: Extraction and Characterization
- Erythrocyte Function and Pathophysiology
- Ocular Surface and Contact Lens
- Evacuation and Crowd Dynamics
- Ion channel regulation and function
- Gastric Cancer Management and Outcomes
- Child Nutrition and Feeding Issues
- Adenosine and Purinergic Signaling
- Metastasis and carcinoma case studies
Nagasaki University
2021-2024
Tachikawa Hospital
2023
University Hospital Kyoto Prefectural University of Medicine
2011
Fukuoka University
1998
BackgroundAtopic dermatitis (AD) is a common chronic eczematous skin disease with severe pruritus. Several new therapeutic agents for AD such as dupilumab, an anti–IL-4Rα antibody, have been developed in recent years. We need to predict which agent the best choice each patient, but this remains difficult.ObjectiveOur aim was examine clinical background factors and baseline biomarkers that could achievement of improved outcomes patients treated dupilumab.MethodsA multicenter, prospective...
To develop precision medicine for atopic dermatitis (AD), it is critical to establish relevant biomarkers. However, the characteristics of various biomarkers have not been fully understood. We previously carried out Biomarkers Predict Clinical Improvement AD in Patients Treated with Dupilumab (B-PAD) study, a comprehensive nationwide study Japan, explore AD.The aim this find associated objective and subjective clinical findings patients moderate-to-severe based on B-PAD identify sensitive...
Abstract Prurigo nodularis (PN) is a chronic inflammatory skin disease associated with intense pruritic nodules. The unclear patho‐etiological mechanisms of PN cause difficulty in management; and there paucity information on the current diagnosis treatment options for Japan. To describe management from dermatologists' perspective we conducted web‐based survey (UMIN Clinical Trial Registry UMIN000047643) 2022 among dermatologists Japanese commercially available physician panel, who had seen...
The effect of high pressure on proliferation and cell cycle progression was examined using murine erythroleukemia (MEL) cells. MEL cells were exposed to pressures (0.1–130 MPa) then cultured for 5 days at atmospheric pressure. unaffected up 60 MPa, but suppressed 80–110 MPa. Above 120 the fragmented. analysis 80 MPa-treated showed that in S phase are most sensitive they arrest G2 phase. Interestingly, G2-arrested reinitiated DNA synthesis, resulting giant with contents. Furthermore, when...
Abstract Objectives This study evaluated the cost‐effectiveness of delgocitinib relative to moisturization therapy in adult patients with moderate severe atopic dermatitis. Methods The analysis was performed by using simulation model patient‐level data from a phase 3 and its longterm extension (QBA4‐1 Study). conducted Japanese public healthcare payer's perspective included only direct medical costs. Health outcomes were quality‐adjusted life years. time horizon one year no discount rate...
Oral allergy syndrome (OAS) is an IgE-mediated food allergy. Ingestion of causative antigens leads to the development local symptoms such as numbness oral mucosa in most cases and anaphylaxis a few cases. The prevalence OAS including healthy people has not been investigated. Thus, we conducted questionnaire survey Japanese university students.We cross-sectional study 2688 first-year students using marksheet format examined epidemiological characteristics OAS.Only 2.7% were aware term "oral...
Assuming a nighttime situation in dementia group home, assistance operations were performed under the condition of 1 assistant, transfer from supine position to floor with full assistance, and low bed (height = 0.4 m).Assistance combinations 4 conditions: starting head side, foot female assistants male evacuees, evacuees.The time was analyzed by dividing it into three operation phases, found that longer.Further, when started took longer pull evacuee front bed, whereas lower floor.Since...
α-Gal syndrome (AGS) is an allergic reaction to galactose-α-1,3-galactose (α-gal) found in the salivary glands of ticks, mammalian meat excluding primates, and some antibody preparations, such as cetuximab. We report two cases AGS diagnosed after ingestion wild boar meat. Patient 1, a male his 70s, developed anaphylactic shock about 3 h eating He was transported our acute critical care center Nagasaki University Hospital because he had difficulty moving. 2, female her 60s, skin rash 2.5...
Abstract Background Recent epidemiological studies have revealed increased numbers of adolescent subjects with atopic dermatitis, most who experienced chronic symptoms since childhood. However, the complete clinical nature dermatitis in Japanese adolescents is poorly understood. We conducted this study to accumulate knowledge factors contributing protracted avoid an unfavorable outcome these patients. Methods On 2013 and 2014, first‐year students at our university answered a retrospective...
<h3>Introduction</h3> In order to determine the prevalence of anaemia and explore associations between iron status intake in process pregnancy, we compared dietary total with Dietary Reference Intakes (DRIs) for Japanese a population pregnant women suburbs. <h3>Methods</h3> A 109 participated survey were measured blood haemoglobin (Hb). For 42 (mean age ±SD: 30.2±4.5) clinically normal (Hb concentration >11 g/dl) first trimester used record methods two consecutive weekdays weekend day...
Abstract Objectives Atopic dermatitis (AD) is aggravated by various factors, including perspiration and heat. Thus, it recommended that AD patients wear breathable clothing to maintain disease remission. Japan has four seasons, so the ideal for individuals with may differ throughout year. The aim of this study was evaluate impact wearing a newly developed performance fabric, named Comfiknit Eczema ® T‐shirt, which absorbs excess from skin surface retains moisture within fabric. We evaluated...
80歳以下で,併存症が軽度であり,かつ薬剤で除痛が得られる上部消化管穿孔に対して保存的治療を行い,穿孔部閉鎖後に胃癌の確定診断を得た症例を7例経験した.1991年から2011年の間に当院に入院した胃癌穿孔症例13例中,7例(53.8%)に保存的治療を行った.全例,保存的に穿孔部は閉鎖して,待機的に開腹した.6例に根治術を施行し,うち5例に5年生存を見た(Stage IIA1例,IIB1例,IIIA4例,以下,胃癌取扱い規約第15版に準拠).1例は局所進行のため非切除であり(Stage IVA),1年以内に癌死した.すなわち,保存的治療を選択した胃癌穿孔症例は,全例保存的に穿孔部閉鎖し,待機的に根治術を行って,比較的良好な予後が得られた.胃癌穿孔症例に対しても,一定の条件の下で初期治療として保存的治療は選択肢となると思われる.