A5103007196- Lung Cancer Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Meningioma and schwannoma management
- Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Vitamin D Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Thyroid and Parathyroid Surgery
- Congenital Diaphragmatic Hernia Studies
- Autophagy in Disease and Therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurofibromatosis and Schwannoma Cases
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Cancer Risks and Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Neuroblastoma Research and Treatments
- Vascular Malformations and Hemangiomas
- Anatomy and Medical Technology
- Surgical Simulation and Training
- Telomeres, Telomerase, and Senescence
- Soft tissue tumor case studies
- Glioma Diagnosis and Treatment
Jikei University School of Medicine
2012-2023
Chest Diseases Hospital
2017
Okayama University Hospital
2015
Kyoto Prefectural University of Medicine
1994-2013
Kanagawa Cancer Center
2007
Kanagawa Prefectural Hospital Organization
2007
Abstract Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron homeostasis resulting excessive oxidative stress has been implicated the pathogenesis chronic obstructive pulmonary disease (COPD). Here, we demonstrate involvement ferroptosis COPD pathogenesis. Our vivo and vitro models show labile accumulation enhanced lipid concomitant non-apoptotic during cigarette smoke (CS)...
Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays a crucial role eliminating damaged mitochondria, and is governed by the PINK1 (PTEN induced putative protein kinase 1)-PRKN (parkin RBR E3 ubiquitin ligase) pathway. Although both increased reduced PRKN have COPD pathogenesis association with mitophagy, there are conflicting reports for mitophagy progression. To clarify...
Abstract Fibroblastic foci, known to be the leading edge of fibrosis development in idiopathic pulmonary (IPF), are composed fibrogenic myofibroblasts. Autophagy has been implicated regulation myofibroblast differentiation. Insufficient mitophagy, mitochondria-selective autophagy, results increased reactive oxygen species, which may modulate cell signaling pathways for Therefore, we sought investigate regulatory role mitophagy differentiation as a part IPF pathogenesis. Lung fibroblasts were...
Abstract Purpose: Higher serum 25-hydroxyvitamin D (25(OH)D) levels are reportedly associated with better survival in early-stage non–small cell lung cancer (NSCLC). Therefore, whether vitamin supplementation can improve the prognosis of patients NSCLC was examined (UMIN000001869). Patients and Methods: A randomized, double-blind trial comparing supplements (1,200 IU/day) placebo for 1 year after operation conducted. The primary secondary outcomes were relapse-free (RFS) overall (OS),...
Pirfenidone (PFD) is an anti-fibrotic agent used to treat idiopathic pulmonary fibrosis (IPF), but its precise mechanism of action remains elusive. Accumulation profibrotic myofibroblasts a crucial process for fibrotic remodeling in IPF. Recent findings show participation autophagy/mitophagy, part the lysosomal degradation machinery, IPF pathogenesis. Mitophagy has been implicated myofibroblast differentiation through regulating mitochondrial reactive oxygen species (ROS)-mediated...
Accumulation of profibrotic myofibroblasts is involved in the process fibrosis development during idiopathic pulmonary (IPF) pathogenesis. TGFB (transforming growth factor β) one major cytokines for myofibroblast differentiation and NOX4 (NADPH oxidase 4) has an essential role TGFB-mediated cell signaling. Azithromycin (AZM), a second-generation antibacterial macrolide, pleiotropic effect on cellular processes including proteostasis. Hence, we hypothesized that AZM may regulate levels by...
The imbalanced redox status in lung has been widely implicated idiopathic pulmonary fibrosis (IPF) pathogenesis. To regulate status, hydrogen peroxide must be adequately reduced to water by glutathione peroxidases (GPx). Among GPx isoforms, GPx4 is a unique antioxidant enzyme that can directly reduce phospholipid hydroperoxide. Increased lipid peroxidation products have demonstrated IPF lungs, suggesting the participation of pathogenesis, which modulated GPx4. In this study, we sought...
The identification of human CD34-negative (CD34−) hematopoietic stem cells (HSCs) provides a new concept for the hierarchy in HSC compartment. Previous studies demonstrated that CD34− severe combined immunodeficiency (SCID)-repopulating (SRCs) are distinct class primitive HSCs comparison to well-characterized CD34+CD38− SRCs. However, purification level rare SRCs 18 lineage marker-negative (Lin−) (1/1000) is still very low compared with (1/40). As mouse, it will be necessary identify useful...
Downregulation of lamin B1 has been recognized as a crucial step for development full senescence. Accelerated cellular senescence linked to mechanistic target rapamycin kinase (MTOR) signaling and accumulation mitochondrial damage implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. We hypothesized that protein levels are reduced COPD lungs, contributing the process cigarette smoke (CS)-induced via dysregulation MTOR integrity. To illuminate role pathogenesis, levels,...
Minimally invasive thoracoscopic lobectomy is the recommended surgery for clinical stage I non-small cell lung cancer (NSCLC). The purpose of this study was to identify risk factors, including sarcopenia, postoperative complications in patients undergoing a complete single-lobe NSCLC, as well impact on disease-free survival.We retrospectively investigated 173 with pathologically-diagnosed NSCLC who underwent curative lobectomies between April 2013 and March 2018. Sarcopenia assessed using...
Thoracoscopic surgery is widely used for the surgical treatment of thymoma. However, large-sized thymomas are typically treated using open surgery. This study evaluated feasibility performing thoracoscopic thymectomy (TT) thymoma ≥50 mm.A retrospective review was conducted on 135 patients who underwent TT or (OT) Masaoka stage I-IVa between 1996 and 2014.Patients were first divided into two groups based size: mm <50 groups. There no significant difference in 5-year disease-free survival...
Longitudinal data for weight and length from birth to the 20th month of age obtained 318 healthy infants were analysed in relation type feeding during infancy (breast- or bottle-fed). Differences growth patterns according confirmed, breast-fed tending be lighter between 6 20 months than bottle- mixed-fed infants. However, our analyses infants' suggest that differences mean breast- bottle-fed may due at least part overfeeding Thus, it is advisable standard curve based on observations a large...
Recurrence of pneumothorax after thoracoscopic surgery is a concerning issue for thoracic surgeons. In this study, we aimed to determine the risk factors recurrence spontaneous surgery.A total 192 patients with aged <50 years who underwent from January 2010 December 2016 were included in study. Pre- and post-operative characteristics obtained medical records, recurrent non-recurrent cases compared.Fourteen (7.3%) experienced recurrence. Pneumothorax was observed more frequently <20 (P=0.041)...
Pulmonary function following lung wedge resection is not fully understood. This study aimed to assess the influence of upon postoperative pulmonary function.We retrospectively evaluated at 3, 6, and 12 months postoperatively in 29 patients who underwent resection. The values tests (PFTs) were compared among time points using a paired t-test.The vital capacity (VC) before surgery 6 2,994±793, 2,845±799, 2,941±801, 2,964±839 mL, respectively. VC decreased 3 (P=0.002) recovered by (P=0.003...
OBJECTIVES: Thoracoscopic thymectomy has gradually replaced conventional sternotomy for resection of thymoma; however, a thoracoscopic approach thymoma remains controversial.We evaluated the oncological outcomes treatment stages I-III thymomas.METHODS: Sixty-two patients who underwent were retrospectively reviewed between July 2005 and September 2011 at Jikei University Hospital.Surgical pathological results I + II stage III compared.RESULTS: Twenty-nine had Masaoka I, 28 5 III.Three needed...
For the purpose of simulating thoracoscopic surgery, we have conducted stepwise development a life-like chest model including thorax and intrathoracic organs.First, CT data human were obtained. First-generation model: based on data, each component was made from 3D printer. A hard resin used for bony rubber-like vessels bronchi. Lung parenchyma, muscles skin not created. Second-generation in addition to printer, cast moulding method used. Each part casted using printed master then assembled....
Abstract Introduction The objective of this study was to evaluate the feasibility thoracoscopic thymectomy ( TT ) for treatment early‐stage thymoma and compare outcomes with those after open OT ). Methods A retrospective review 98 patients who underwent or M asaoka stage I ‐ II without thymic cancer between 1996 2013 performed. Results Thoracoscopic performed in 67 patients, 31 patients. intraoperative blood loss amounts differed significantly group (100 vs 185 m L , P = 0.0070)....
Background: We assessed how the severity of chronic obstructive pulmonary disease (COPD) and other comorbidities affect long-term survival after thoracoscopic lung resection for c-stage I non-small cell cancer (NSCLC).
Difficult thoracoscopic surgery sometimes requires a long operative time. It is unclear whether patients benefit from such surgeries. We investigated for difficult cases contributed to improvements in perioperative outcomes. retrospectively reviewed of anatomical lung resection with surgery, including conversion thoracotomy, between January 2006 and December 2016 compared patient demographics outcomes the (≥360 min) normal time groups (<360 min). One hundred seventy-six were group 655 group....
Abstract Introduction Secondary spontaneous pneumothorax ( SSP ) can be life threatening because patients often have severe lung disease with other coexisting diseases such as heart disease. In this study, we evaluate the feasibility of thoracoscopic surgery to treat and discuss techniques for managing complicated cases. Methods We retrospectively evaluated outcome surgeries in 21 patients. Results Fifteen had chronic emphysema, four interstitial pneumonia, two inflammatory All presented...