A5070764415- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Cell Adhesion Molecules Research
- Tracheal and airway disorders
- Autophagy in Disease and Therapy
- Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Congenital Diaphragmatic Hernia Studies
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Neuroendocrine Tumor Research Advances
- Myasthenia Gravis and Thymoma
- Synthesis of β-Lactam Compounds
- Human Pose and Action Recognition
- Carbohydrate Chemistry and Synthesis
- Neuroblastoma Research and Treatments
- Hand Gesture Recognition Systems
- Cancer Mechanisms and Therapy
- Thyroid Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Colorectal Cancer Treatments and Studies
- Virus-based gene therapy research
Fukuyama City Hospital
2024
Yamaha (Japan)
2023-2024
Japanese Red Cross Society Kyoto Daini Hospital
2021-2023
Kyoto Prefectural University of Medicine
2018-2021
Teikyo University
1999-2021
CHI Health
2015-2021
Kagawa University
2003-2020
Tokyo University of Social Welfare
2020
Jikei University School of Medicine
2019
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
2019
To optimize a receptor-mediated and cell-selective gene transfer with polyethyleneimine (PEI)-based vector, we synthesized three galactosylated PEIs (Gal-PEI) different molecular weights (PEI(1800), PEI(10,000), PEI(70,000)) investigated their potential as targetable vector to asialoglycoprotein receptor-positive cells. All PEI derivatives formed complexes plasmid DNA (pDNA), whereas the particle size of complex became smaller on increasing weight PEI. Transfection efficiency in HepG2 cells...
Downregulation of lamin B1 has been recognized as a crucial step for development full senescence. Accelerated cellular senescence linked to mechanistic target rapamycin kinase (MTOR) signaling and accumulation mitochondrial damage implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. We hypothesized that protein levels are reduced COPD lungs, contributing the process cigarette smoke (CS)-induced via dysregulation MTOR integrity. To illuminate role pathogenesis, levels,...
Background/Aim: Myeloid cell leukemia-1 (MCL-1) is a member of the B-cell lymphoma-2 (Bcl-2) family proteins, which regulate intrinsic (mitochondrial) apoptotic cascade. MCL-1 inhibits apoptosis, may be associated with resistance to cancer therapy. Therefore, in this study, clinical role non-small lung (NSCLC) was explored. Patients and Methods: This retrospective study included 80 patients stage 1-3A NSCLC, who underwent surgery without preoperative treatment between 2010 2011. expression...
Our previous study showed that tumor budding is a significant indicator of poor prognosis in lung squamous cell carcinoma patients. Tumor budding-positive (Bud(+)) cases (SqCC) locally aggressive growth, and the positivity was useful lymph node status prognosis. The present focused on clinicopathologic significance laminin-5γ2 chain expression for local aggressiveness SqCC. Laminin-5γ2 immunohistochemical stains tissue samples were divided into three distinct types: basement membrane (B...
The biochemical interactions between the Cdk2/Cyclin E kinase and its inhibitor p27, were investigated using purified, recombinant p27 CAK-phosphorylated E. From kcat/Km determinations either histone H1 or pRb as substrates, we found that has 60-fold higher specificity for than H1. IC50 value of increased with increasing concentrations while it remained constant at various ATP concentrations, suggesting acts a tight binding We also could be phosphorylated by only high enzyme forms stable...
Adjuvant platinum-based chemotherapy is recommended for patients with completely resected stage II (N1) or III (N2) non-small cell lung cancer (NSCLC). However, the optimal regimen difficult to predict individual patients. Our previous prospective study on individualized treatment according biomarker status, such as excision repair cross-complementing 1 (ERCC1), class β-tubulin (tubulin), thymidylate synthase (TYMS) and ribonucleotide reductase M1 (RRM1), achieved encouraging results in...
To date, the efficacy and safety of programmed death-ligand 1 (PD-L1) inhibitor plus platinum-etoposide chemotherapy for patients with extensive-stage SCLC (ES-SCLC), real-world evidence, stratified on basis age performance status (PS), have not been fully investigated. The aim this study was to evaluate PD-L1 in ES-SCLC.This multicenter prospective evaluated ES-SCLC who received between September 2019 October 2021.A total 45 aforementioned treatment, including 18 elderly (≥75 y old) six a...
Fresh loquat leaves have been used as folk health herb in Asian countries for long time, although the evidence supporting their functions is still minimal. This study aimed to clarify chemopreventive effect of tea extract (LTE) by investigating inhibition on proliferation, and underlying mechanisms human promyelocytic leukemia cells (HL-60). LTE inhibited proliferation HL-60 a dose-dependent manner. Molecular data showed that isolated fraction induced apoptosis characterized DNA...
We report a case of papillary adenoma the lung with peculiar raw macroscopic feature at intraoperative consultation. A 52‐year‐old man was admitted to our hospital for evaluation solitary peripheral nodule in left lower lobe which detected chest CT. When we took staples off from stump partially resected order make frozen section diagnosis, granular fragments leaked out stump. On cut surface, dark reddish and tumor grew expansively; however, hemorrhage necrosis were absent. Histologically,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvent Effects in the Reaction of Grignard Reagent with 1-Alkynes1Harukichi Hashimoto, Takayuki Nakano, and Hiroyoshi OkadaCite this: J. Org. Chem. 1965, 30, 4, 1234–1239Publication Date (Print):April 1, 1965Publication History Published online1 May 2002Published inissue 1 April 1965https://pubs.acs.org/doi/10.1021/jo01015a066https://doi.org/10.1021/jo01015a066research-articleACS PublicationsRequest reuse permissionsArticle...
GPR87 is a member of the cell surface molecular G protein-coupled receptors (GPCR) family and suggested to contribute viability human tumor cells. Its tumor-specific expression location make it potential molecule for targeted therapy. In present study, we aimed examine effect silencing explore possibility establishing gene therapy against GPR87-overexpressing lung cancer.Twenty malignant lines were investigated H358 PC9 cancer cells subjected inhibiting experiments. A short hairpin siRNA...
The prognoses of patients with non-small-cell lung cancer (NSCLC) harboring anaplastic lymphoma kinase (ALK) gene rearrangement have dramatically improved the use ALK tyrosine inhibitors. Although immunological and nutritional markers been investigated to predict outcomes in several cancers, their usefulness targeted therapies is scarce, significance has never reported receiving first-line treatment alectinib. Meanwhile, neutrophil-to-lymphocyte ratio platelet-to-lymphocyte (PLR) during...
We investigated a (supervised) deep learning model for the automatic segmentation of manufacturing video data into sequence assembly operations. In action general human behavior, various temporal convolutional network (TCN)-based methods have been proposed and demonstrated to stable performance using features from captured extensive fields image frames. However, they often make it difficult detect unusual actions occurring in short durations, such as skipping this paper, we address drawback...
Abstract Background Patients with epidermal growth factor receptor ( EGFR )‐mutated, advanced non–small cell lung cancer have received immunochemotherapy as one of the treatment options after tyrosine kinase inhibitor (TKI) failure. Methods We retrospectively examined ‐mutant patients treated atezolizumab‐bevacizumab‐carboplatin‐paclitaxel (ABCP) therapy or platinum‐based chemotherapy (Chemo) EGFR‐TKI at five institutions in Japan. Results A total 57 mutation were analyzed. The median...
NSCLC patients with EGFR mutations respond to EGFR-TKIs; however, the management of refractory tumors EGFR-TKIs remains unclear. We demonstrated that repeated genetic testing might be useful for detecting resistance mechanisms as well decision-making in mutated patients, following emergence initial EGFR-TKIs. A 69-year-old man was diagnosed lung adenocarcinoma an exon 19 deletion. After tumor re-growth treated erlotinib and chemotherapy, he SCLC transformation administered chemotherapy treat...