A5065236967- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Multiple and Secondary Primary Cancers
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Cardiac Arrest and Resuscitation
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Transplantation: Methods and Outcomes
- T-cell and Retrovirus Studies
- Hemoglobin structure and function
- CNS Lymphoma Diagnosis and Treatment
- Methemoglobinemia and Tumor Lysis Syndrome
- Congenital Diaphragmatic Hernia Studies
- Childhood Cancer Survivors' Quality of Life
- Frailty in Older Adults
- Trauma Management and Diagnosis
- Respiratory viral infections research
- Medical Imaging and Pathology Studies
- Multiple Myeloma Research and Treatments
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Neutropenia and Cancer Infections
- Neonatal Health and Biochemistry
- Nutrition and Health in Aging
University of Fukui
2016-2025
Nagoya City University
2020-2024
Nagoya University Hospital
2024
Tokai University
2009-2024
Otsu Municipal Hospital
2023
University of Fukui Hospital
2018-2019
Abbott (Sweden)
2009
Abstract Reflecting the increasing risk in elderly patients with diffuse large B cell lymphoma (DLBCL), prognostic predictors other than International Prognostic Index have attracted more attention. This study presents first analysis of utility Geriatric Nutritional Risk (GNRI) combination Charlson Comorbidity (CCI) for overall survival (OS) DLBCL patients. A multicentre retrospective was conducted on a cohort 451 (≥65 years). The GNRI and CCI were independent multivariate Cox proportional...
Tumor lysis syndrome (TLS) is a life-threatening complication associated with cancer chemotherapy. We retrospectively evaluated the risk of developing TLS in patients symptomatic multiple myeloma undergoing chemotherapy.Sixty-four (median age=71 years, range=48-87 35 males/29 females) who were treated at our Institution between April 2006 and December 2015 evaluated.A total 124 chemotherapy courses administered, which 63 bortezomib-based regimens 34 immunomodulatory drug (IMiD)-based...
Abstract Background Invasive fungal infections (IFIs) represent a potentially fatal complication in patients who undergo allogeneic hematopoietic stem cell transplantation (HSCT) if the initiation of therapy is delayed. Some guidelines recommend antifungal prophylaxis or preemptive for these depending on risk IFIs following HSCT. This retrospective study aimed to identify group safely HSCT with low‐dose fluconazole (FLCZ) (100 mg/day). Methods We retrospectively reviewed 107 underwent their...
<title>Abstract</title> To evaluate the effect modification of age on associations between geriatric nutritional risk index (GNRI) and overall survival (OS) in ≥18-year-old patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL), we conducted a multi-centre retrospective study 552 analysable patients. Multivariable Cox modelling restricted cubic spline (RCS) showed that GNRI correlated significantly OS, but relationship is non-linear (<italic>P</italic> for non-linearity =...
Our previous study showed that tumor budding is a significant indicator of poor prognosis in lung squamous cell carcinoma patients. Tumor budding-positive (Bud(+)) cases (SqCC) locally aggressive growth, and the positivity was useful lymph node status prognosis. The present focused on clinicopathologic significance laminin-5γ2 chain expression for local aggressiveness SqCC. Laminin-5γ2 immunohistochemical stains tissue samples were divided into three distinct types: basement membrane (B...
Abstract Background The management of severe adverse events (AEs) is important in safely and effectively providing chemotherapy to older adults with diffuse large B-cell lymphoma (DLBCL). However, reports on simple DLBCL-specific predictive models for treatment-related toxicity elderly individuals are scarce. aim this study was examine the usefulness Geriatric 8 (G8) predicting AEs, nonhematological toxicity, febrile neutropenia DLBCL real-world practice. Materials Methods We conducted a...
Summary Because of the heterogeneity among older patients with diffuse large B‐cell lymphoma (DLBCL), establishment an easy‐to‐use geriatric assessment tool is unmet need. We verified impact Geriatric 8 (G8) on treatment stratification and overall survival (OS). conducted a retrospective, multicentre analysis (≥65 years) DLBCL. The primary endpoint was OS. total average relative dose intensity (tARDI) defined as delivered divided by planned through all cycles. A 451 were diagnosed DLBCL from...
Percutaneous cryoablation has been adopted for small, malignant peripheral pulmonary lesions and yielded favourable results as a less invasive local treatment. A transbronchial approach may reduce the risks of complications, such pneumothorax pleural haemorrhage. fundamental animal experiment on was performed to examine its immediate safety effectiveness.Experimental swine lungs using rigid cryoprobe, 2.4 mm in diameter. The probe introduced from right main bronchus into distal via...
Disseminated intravascular coagulation (DIC) is a life-threatening condition that frequently occurs in patients with hematologic malignancies. Currently, recombinant human soluble thrombomodulin (rTM) therapeutic DIC drug manufactured and sold Japan only. We evaluated the efficacy of rTM compared to gabexate mesilate (GM), which was previously used routinely for treating Japan, acute myeloid leukemia (AML). This retrospective study enrolled 43 AML patients, including 17 promyelocytic (APL),...
Background Haemoglobin vesicles (HbVs) are red blood cell (RBC) substitutes with a phospholipid bilayer membrane and polyethylene modified surface (diameter=250 nm; P 50 =28 Torr). They can be preserved for years used in patients of all types without the risk infection. Their oxygen affinity by changing allosteric effectors. Methods Left pneumonectomy was performed under mechanical ventilation on rats, followed rapid exsanguination ~30% total circulating volume. Rat RBCs shed 5% human serum...
Objective We retrospectively compared the clinical efficacy and toxicity of rituximab (R)-THP-COP (pirarubicin, cyclophosphamide, vincristine, prednisolone) with that R-CHOP (rituximab, adriamicin, in previously untreated old patients diffuse large B-cell lymphoma (DLBCL). Patients Methods admitted to our institution between 2004 2013 were examined. The received either R (375 mg/m2, day 1)-THP-COP (pirarubicin 50 mg/m2 1, cyclophosphamide 750 vincristine 1.4 prednisolone 100 mg 1-5) or...
Pralatrexate (PDX) is a novel antifolate approved for the treatment of patients with relapsed/refractory peripheral T-cell lymphoma, but some exhibit intrinsic resistance or develop acquired resistance. Here, we evaluated mechanisms underlying to PDX and explored potential therapeutic strategies overcome resistance.To investigate resistance, established two PDX-resistant T-lymphoblastic leukemia cell lines (CEM MOLT4) through continuous exposure increasing doses PDX. The were by measuring...
Extranodal involvement predicts poor outcomes of diffuse large B cell lymphoma (DLBCL), but the impact metabolic tumor burden (MTV) extranodal sites using positron emission tomography has not been clarified. This study aimed to assess MTV on overall survival (OS). We retrospectively analyzed 145 newly diagnosed DLBCL patients and verified prognostic each nodal MTV. Multivariate Cox hazards modelling both as covariables identified a significant factor for OS (hazard ratio [HR] 1.072, 95%...
•The optimal number of cycles standard regimens including R-CHOP-21 for newly diagnosed DLBCL has not been determined.•This study was conducted to verify whether six or eight regimen improved the prognosis DLBCL.•Propensity score matching and a Cox hazards model with restricted cubic spline were used in this study.•No survival benefit compared seen, even taking into account RDI.•Prognosis no better (R-)CHOP-21 THP-COP-21 than cycles, after age IPI modifications. BackgroundR-CHOP-21 treatment...
Hemoglobin vesicles (HbVs), liposomes containing concentrated hemoglobin extracted from outdated human red blood cells (RBC), are artificial oxygen carriers with a small particle size. To evaluate the reperfusion of capillaries HbVs in tracheal transplant model and compare it that RBC. Isogenic mice were used as donors recipients parallel trachea model. Both ends donor anastomosed end-laterally to recipient form parallel. After transplantation, 0.3 mL HbV solution (Hb concentration, 10 g/dL)...
Postintubation tracheal stenosis involves granulation or cicatrization of the epithelium. It is progressive and can become life-threatening within a few months after extubation. We here report case with delayed manifestation, presenting 35 years endotracheal intubation for neonatal resuscitation. A female patient complained dyspnea during pregnancy. Bronchoscopy revealed 75% constriction lumen by cicatrization, from 2nd to 4th rings. After child-birth, scar tissue was ablated using argon...
Most clonal cytogenetic abnormalities of Philadelphia-negative cells (CCA/Ph-) occurring during tyrosine kinase inhibitor (TKI) treatment are transient, and the development secondary myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) is rare, but frequency clinical significance in Japanese patients still unknown. We herein report four who developed CCA/Ph- TKI therapy were diagnosed with MDS/AML. The duration from initiation to MDS/AML onset ranged 3 48 months, survival 5 84 months....
Abstract Background: The enzyme purine nucleoside phosphorylase (PNP) is involved in the salvage pathway and present at high levels lymphoid tissues. Children born with PNP deficiency are known to have significantly reduced T-cell counts but relatively normal B-cell immunity, suggesting as one of most promising therapeutic targets for malignancies. Forodesine (For, BCX-1777), a novel inhibitor, was approved Japan treatment relapsed/refractory PTCL. To understand cytotoxic effect For its...