A5112613112- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- RNA Interference and Gene Delivery
- S100 Proteins and Annexins
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
- Photoacoustic and Ultrasonic Imaging
- NF-κB Signaling Pathways
- Trace Elements in Health
- Adenosine and Purinergic Signaling
- Cancer-related gene regulation
- Ultrasound and Hyperthermia Applications
- Bone Metabolism and Diseases
- Meat and Animal Product Quality
- interferon and immune responses
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Cell death mechanisms and regulation
- Receptor Mechanisms and Signaling
Shaoguan University
2024-2025
Chengdu Women's and Children's Central Hospital
2025
Chengdu Medical College
2025
Hunan Normal University
2018-2024
Wuhan University of Science and Technology
2024
University of South China
2019-2024
Fujian Medical University
2022-2024
Xi'an University of Technology
2024
Panzhihua Central Hospital
2024
Fujian University of Traditional Chinese Medicine
2024
Abstract Background Sepsis is life-threatening disease with systemic inflammation and can lead to various diseases, including septic acute kidney injury (AKI). Recently, diverse circular RNAs (circRNAs) are considered be involved in the development of this disease. In study, we aimed elucidate role circ-FANCA potential action mechanism sepsis-induced AKI. Methods HK2 cells were treated lipopolysaccharide (LPS) establish AKI cell model. The expression circ-FANCA, microRNA-93-5p (miR-93-5p)...
Abstract Aloe emodin is an anthraquinone of traditional Chinese medicine monomer, which plays a protective action in cardiovascular diseases. However, the regulatory mechanisms aloe protection radiation‐induced heart damage (RIHD) are unclear. As novel post‐translational modification, lactylation considered as critical mediator inflammatory cascade and cardiac injury. Here, using cross differential omics 4D label‐free omics, protein disulfide‐isomerase (P4HB) identified target for...
Potassium ion channels are emerging as promalignant factors involved in cancer progression. In this study, we found that invading human gastric cells express high levels of inwardly rectifying potassium channel 2.1 (Kir2.1). Silencing Kir2.1 markedly reduced the invasive and metastatic capabilities well epithelial-mesenchymal transition (EMT) cells. The nature was independent permeation but relied on its interaction with serine/threonine-protein kinase 38 (Stk38) to inhibit ubiquitination...
Abstract Background Bladder cancer is the second most common genitourinary malignancy worldwide. The death rate of bladder has increased every year. However, molecular mechanism not sufficiently studied. Deubiquitinating enzymes (DUBs) play an important role in carcinogenesis. Several studies have demonstrated that USP5 associated with and pathological progression hepatocellular carcinoma, colorectal non-small cell lung cancer. need to be explored. Methods expression was analysed using web...
Abstract Ligands for peroxisome proliferator-activated receptor γ (PPARγ), such as 15-deoxy-Δ12,14PGJ2 (15d-PGJ2) have been proposed a new class of antiinflammatory compounds with possible clinical applications. As there is some controversy over the inhibitory effects 15d-PGJ2 on chemokine gene expression, we investigated whether itself affected expression in human monocytes/macrophages and two monocytic cell lines. Here demonstrate that can induce IL-8 expression. In contrast, monocyte...
Preeclampsia (PE) is a prevalent pregnancy disorder that has been one of the leading causes maternal and perinatal mortality worldwide. Circular RNAs (circRNAs) have recently considered as important regulators in PE pathogenesis. In current study, we aimed to explore impact mechanisms circRNA zinc finger DHHC-type palmitoyltransferase 20 (circZDHHC20) pathogenesis.RNase R assay reverse transcription with Oligo(dT)18 primers were performed confirm circZDHHC20 was indeed circular transcript....
Abstract Macrophage CSF (M-CSF) regulates monocyte differentiation, activation, and foam cell formation. We have observed that it is elevated in human pulmonary alveolar proteinosis (PAP) the GM-CSF knockout mouse, a murine model for PAP. A potential regulator of M-CSF, peroxisome proliferator-activated receptor-γ (PPARγ), severely deficient both PAP mouse. To investigate role PPARγ macrophage homeostasis, we generated myeloid-specific mice using Lys-Cre method to knock out floxed gene....
Programmed cell death 4 (PDCD4) is a newly identified tumor suppressor that can inhibit activator protein (AP)-1 activation and translation. Our previous studies indicate lost or reduced PDCD4 expression associated with the progression of ovarian carcinoma. However, direct evidence inhibits malignant phenotype human cancer cells limited. In present study, we found in lines (SKOV3, 3AO, CAOV3) inhibited significantly their proliferation cycle progression, induced apoptosis. More importantly,...
IL-12 is a dimeric cytokine that produced primarily by APCs. In this study we examined the role p38 MAPKs (MAPK/p38) play in regulating production. We show inhibition of dramatically increased production upon stimulation, while decreasing TNF-α. This reciprocal effect on these two cytokines following MAPK/p38 occurred many different APCs, variety stimuli. was also macrophages treated with small interfering RNA to limit p38α expression, and deficient MKK3, kinase upstream p38. The increase...
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase, whose activity inhibited by AKT phosphorylation. This inhibitory phosphorylation of GSK3β can in turn play regulatory role through several proteins (such as mTOR, elF2B) to promote protein synthesis. mTOR key regulator synthesis and cell proliferation, recent studies have shown that both mTORC1 regulate SREBP1 fat Thus far, however, the cross talk between pathway regulation milk associated proliferation not well understood. In...
Cervical cancer is one of the diseases that seriously endanger women’s health. Circular RNA plays an important role in regulating occurrence and development cervical cancer. Here, we investigated mechanisms circ SMARCA5 Quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) results showed expression was downregulated tissues cell lines. Then found overexpression inhibited proliferation invasion, but promoted apoptosis cells. These were detected by Cell Counting Kit-8,...
Chemoresistance is a major cause of treatment failure in ovarian cancer. Therefore, it necessary to explore alternative therapeutic methods overcome drug resistance for cancer treatment. We previously reported that programmed cell death 4 (PDCD4), tumor suppressor, significantly suppresses the malignant phenotype cells and its lost or low expression associated with unfavorable prognosis patients. Here we show PDCD4 improves sensitivity platinum‐based chemotherapy. Overexpression enhanced...
Background: The NOD-like receptor family pyrin domain-containing 3 (NLRP3) -mediated neuroinflammation is linked to neuronal necroptosis in cerebral ischemia-reperfusion (I/R) injury, especially ischemic penumbra. This study was designed investigate the regulation of nuclear factor E2-related factor-2 (Nrf2) on NLRP3 inflammasome signal pathway induced by I/R injury. Methods: We investigated mechanisms Nrf2-negative signaling using middle artery occlusion (MCAO) with Q-VD-OPH injected...
Abstract Human formyl peptide receptor-like 1 and its mouse homologue receptor 2 (FPR2) are G protein-coupled receptors used by a number of exogenous host-derived chemotactic peptides, including the 42 aa form β amyloid peptide, causative factor Alzheimer’s disease. Functional FPR2 was induced bacterial LPS in murine microglial cells, resident phagocytic cells that play pivotal role inflammatory immunological diseases CNS. To identify agents may suppress cell activation under proinflammatory...
Abstract DNA methylation plays important roles in regulating many physiological behaviors; however, few studies were focused on the changes of during oocyte aging. Early showed that some imprinted genes’ had been changed aged mouse oocytes. In this study, we used porcine oocytes to test hypothesis aging would alter pattern genes and disturb their expression age oocytes, which affected developmental potential We compared several different types found Neuronatin ( NNAT ) disturbed...
Human glioblastomas (GBM) are thought to be initiated by glioma stem-like cells (GSLCs).GSLCs also participate in tumor neovascularization transdifferentiating into vascular endothelial cells.Here, we report a critical role of GSLCs the formation vasculogenic mimicry (VM), which defines channels lined supply nutrients early growing tumors and initiation.GSLCs preferentially expressed growth factor receptor-2 (VEGFR-2) that upon activation VEGF, mediated chemotaxis, tubule increased...
Abstract Circular RNA FAT atypical cadherin 1 (circFAT1) has been reported to play vital roles in the progression of some cancers. However, regulatory role and underlying mechanisms circFAT1 cervical cancer (CC) remain largely unknown. The expression circFAT1, microRNA (miR)‐409‐3p cyclin‐dependent kinase 8 (CDK8) was detected using qRT‐PCR Western blot assays. Cell proliferation, apoptosis, migration invasion vitro were investigated cell counting kit‐8, colony formation, flow cytometry,...
Pig cloning by somatic cell nuclear transfer (SCNT) frequently undergoes incomplete epigenetic remodeling during the maternal-to-zygotic transition, which leads to a significant embryonic loss before implantation. Here, we generated first genome-wide landscapes of histone methylation in pig SCNT embryos. Excessive H3K9me3 and H3K27me3, but not H3K4me3, were observed genomic regions with unfaithful genome activation donor-cell-specific gene silencing. A combination H3K9 demethylase KDM4A...
Abstract Microglia are phagocytic cells in the CNS and actively participate proinflammatory responses neurodegenerative diseases. We have previously shown that TNF-α up-regulated expression of formyl peptide receptor 2 (mFPR2) mouse microglial cells, resulting increased chemotactic such to mFPR2 agonists, including amyloid β1–42 (Aβ42), a critical pathogenic agent Alzheimer’s disease. In present study, we found IL-4, Th2-type cytokine, markedly inhibited TNF-α-induced by attenuating...