A5101689453- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Medicinal Plants and Bioactive Compounds
- Phytochemistry and Biological Activities
- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Fungal and yeast genetics research
- Genomics and Phylogenetic Studies
- Molecular Biology Techniques and Applications
- Brucella: diagnosis, epidemiology, treatment
- Fungal Biology and Applications
- Plant chemical constituents analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Chromatography in Natural Products
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Medicinal Plant Pharmacodynamics Research
- Phytochemical compounds biological activities
- Plant biochemistry and biosynthesis
- Cancer-related gene regulation
- Water Treatment and Disinfection
- MicroRNA in disease regulation
- Ginger and Zingiberaceae research
- Acute Kidney Injury Research
Guangzhou University
2025
Beijing University of Technology
2024-2025
Shaoxing People's Hospital
2025
Chinese General Hospital College of Nursing and Liberal Arts
2025
Shihezi University
2013-2024
Beijing University of Chinese Medicine
2020-2024
Lanzhou University
2017-2024
Jiangnan University
2003-2023
Taizhou Second People's Hospital
2022
Second Affiliated Hospital of Zhengzhou University
2014-2021
Idiopathic Pulmonary fibrosis (IPF) is diagnosed as a life-threatening, progressive and incurable lung disease characterized by accumulation of extracellular matrix myofibroblasts, resulting in the function degradation structural alterations normal parenchyma. Notably, Fibrosis has been considering difficult problem clinical with high mortality effective treatment strategies. Rosavin, benzylPropylene glycoside, isolated from Rhodiola rosea L., exhibiting nootropic, anti-depressant,...
A rising amount of evidences show that gut microbiota is an important factor in mediating the growth ulcerative colitis (UC), major product colon bacteria fermentation butyrate as mediator have effects on mucosal immune system by expanding regulatory T cells (Treg) colon. Turkish galls, insect gall parasitized tree branches Quercus infectoria Oliv., exhibiting promising prospect treating remedy UC regulating bacteria, whereas its mechanism remains unclear. Here, this work found three types...
Rhodiola rosea L. (RRL) possesses a wide range of pharmacological properties, including lung-protective activity, and has been utilized in folk medicine for several 100 years. However, the mechanism remains unclear. This study investigated possible activity RRL pulmonary fibrosis (PF) rat model. Lung fibrotic injury was induced Sprague–Dawley rats by single intratracheal instillation saline containing bleomycin (BLM; 5 mg/kg). The were administered 125, 250, or 500 mg/kg 95% ethanol extract...
Direct infusion (DI) has an extraordinary high-throughput advantage. Pseudo-targeted metabolomics (PTM) been demonstrated integrating the merits of both nontargeted and targeted metabolomics. Herein, we attempted to implant DI into PTM concept configure a new strategy allowing shotgun PTM. First, versatile MS/MSALL program was applied acquire MS1 MS2 spectra. Second, online energy-resolved MS (online ER-MS) conducted obtain breakdown graph as well optimal collision energy (OCE) for each ion...
Although serving as the workhorse, MS/MS cannot fully satisfy analytical requirements of quantitative sub-metabolome characterization. Because more information intrinsically correlates to structural and concentration clues, here, efforts were devoted comprehensively tracing deciphering behaviors through constructing triple three-dimensional (3×3D)-MS/MS spectrum. Ginsenosides-targeted metabolomics notoginseng, one most famous edible medicinal plants, was employed a proof-of-concept. Serial...
Oxidative DNA damage is a threat to genome stability. Using genetic system in yeast that allows detection of mitotic recombination, we found the frequency crossovers greatly elevated when cells are treated with hydrogen peroxide (H2O2). combination microarray analysis and genomic sequencing, mapped breakpoints recombination events other chromosome rearrangements at resolution about 1 kb. Gene conversions were two most common types events, but also observed deletions, duplications,...
Direct infusion-mass spectrometry (DI-MS) currently serves as an alternative analytical tool for metabolomics owing to the unique high-throughput advantage. Except inherent shortcoming at a significant matrix effect, there are two other primary technical obstacles dampening its wide applications, such data alignment and structural annotation. To address these obstacles, novel strategy termed DI-three-dimensional-MS (DI-3D-MS) was proposed here, chemome comparison among several confusing...
Cervical cancer is one of the diseases that seriously endanger women’s health. Circular RNA plays an important role in regulating occurrence and development cervical cancer. Here, we investigated mechanisms circ SMARCA5 Quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) results showed expression was downregulated tissues cell lines. Then found overexpression inhibited proliferation invasion, but promoted apoptosis cells. These were detected by Cell Counting Kit-8,...
Acute lung injury (ALI) is a serious inflammatory disease with high morbidity and mortality. Rosavin an anti-inflammatory antioxidant phenylpropanoid glucoside, which isolated from Rhodiola rosea L. However, its potential molecular mechanisms whether it has protective effects against lipopolysaccharide (LPS)-induced ALI remain to be elucidated. To assess the in vitro anti-lung activity of rosavin, RAW264.7 A549 cells were stimulated using 1 μg/mL LPS. attenuated LPS-induced activation...
Glycoside hydrolase family 18 (GH18) proteins can hydrolyze the β-1,4-glycosidic bonds of chitin, which is a common structure component insect exoskeletons and fungal cell walls. In this study, 36 GH18 genes were identified subjected to bioinformatic analysis based on genomic data Glycine max. They distributed in 16 out 20 tested soybean chromosomes. According amino acid sequences, they be further divided into five subclades. Class III chitinases (22 members) class V (6 are major two The...
Summary Formation of root nodules is a unique hallmark the symbiotic interaction between legume host plants and rhizobia governed by complex regulatory framework that balances appropriate orchestration rhizobial infection subsequent nodule organogenesis. In contrast to prominent model species such as Medicago truncatula Lotus japonicus , research on signal transduction in staple‐crop soybean Glycine max remains relatively insufficient. Here, we identified mutant with ~25% additional over...
<title>Abstract</title> Human papillomavirus (HPV) infection is a major threat to women’s health worldwide. High-risk subtypes, particularly HPV16, require rigorous screening and long-term surveillance control cervical cancer. However, traditional HPV testing hampered by the need for nucleic acid extraction, reliance on specialized technicians, fluorescence detection equipment, limiting its suitability rapid on-site testing. In this study, we developed Concanavalin A-assisted extraction-free...
ABSTRACT Spinal cord injury (SCI) is a serious clinical condition characterised by extensive mechanical damage that compromises the tissue structure and microenvironment of affected area. This leads to formation fibrotic blood vessels impaired energy metabolism, both which hinder recovery. Felodipine, clinically approved antihypertensive drug, acts as selective calcium antagonist, primarily inhibiting extracellular influx in arteriolar smooth muscle selectively dilating arterioles....