A5100708851- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- Drug-Induced Hepatotoxicity and Protection
- Bioactive Natural Diterpenoids Research
- Fungal Biology and Applications
- Ginseng Biological Effects and Applications
- Phytochemicals and Antioxidant Activities
- Spinal Cord Injury Research
- Biological Activity of Diterpenoids and Biflavonoids
- Plant biochemistry and biosynthesis
- Liver physiology and pathology
- MicroRNA in disease regulation
- Ginger and Zingiberaceae research
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Peroxisome Proliferator-Activated Receptors
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Bioactive natural compounds
- Medicinal Plants and Bioactive Compounds
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Bioactivity Studies
Kunming Medical University
2022-2024
Harbin University of Commerce
2017-2024
Peking University Cancer Hospital
2024
Peking University
2024
Qilu Hospital of Shandong University
2022-2023
Anhui Agricultural University
2022-2023
Shihezi University
2010-2020
Bioscience (China)
2020
Hebei Medical University
2019
Xinjiang Uygur Autonomous Region Education Department
2017
Idiopathic Pulmonary fibrosis (IPF) is diagnosed as a life-threatening, progressive and incurable lung disease characterized by accumulation of extracellular matrix myofibroblasts, resulting in the function degradation structural alterations normal parenchyma. Notably, Fibrosis has been considering difficult problem clinical with high mortality effective treatment strategies. Rosavin, benzylPropylene glycoside, isolated from Rhodiola rosea L., exhibiting nootropic, anti-depressant,...
To explore the efficacy and safety of single-agent programmed cell death protein-1 (PD-1) inhibitor in neoadjuvant treatment patients with mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) locally advanced colorectal cancer (LACRC) through single-center large⁃sample analysis based on real⁃world data China.This study was a retrospective, single-center, case series study. 33 (CRC) clinical stage T3~4N0~2M0 treated Yunnan Cancer Hospital from June 2019 to 2021 were...
To investigate the hepatoprotective effect of a Cichorium intybus L. extract (CIE) on CCl4-induced hepatic fibrosis in rats.
Rhodiola rosea L. (RRL) possesses a wide range of pharmacological properties, including lung-protective activity, and has been utilized in folk medicine for several 100 years. However, the mechanism remains unclear. This study investigated possible activity RRL pulmonary fibrosis (PF) rat model. Lung fibrotic injury was induced Sprague–Dawley rats by single intratracheal instillation saline containing bleomycin (BLM; 5 mg/kg). The were administered 125, 250, or 500 mg/kg 95% ethanol extract...
Objective Examine patients with locally advanced rectal cancer (LARC) deficient mismatch repair (dMMR) or microsatellite instability-high (MSI-H) who received neoadjuvant immunotherapy (nIT), and compare the outcomes of those chose a watch-and-wait (WW) approach after achieving clinical complete response (cCR) near-cCR underwent surgery were confirmed as pathological (pCR). Methods LARC dMMR/MSI-H nIT retrospectively examined. The endpoints 2-year overall survival (OS), disease-free (DFS),...
Retinoid X receptor alpha (RXRA) is a well-characterized factor that regulates lipid metabolism; however, the regulatory mechanism in muscle cells of poultry still unknown. The overexpression and knockdown RXRA myoblasts (CS2 cells), RT-PCR, western blotting were used to detect expression levels genes proteins related PPAR-signaling pathways. Intracellular triglycerides (TGs), cholesterol (CHOL), nonesterified free fatty acids (NEFAs) detected by Elisa kit. Fat droplets stained with Oil Red...
A new tetrahydrofuran-type lignan, episesaminone (1), was isolated from Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag. Its structure established by spectroscopic techniques (HR-MS, 1D NMR, 2D and circular dichroism). The anti-inflammatory activity in RAW 264.7 macrophages carried out on 1 other eight known compounds, the epimer of (2) seven furofurans-type lignan (3–9) obtained A. mandshuricum. Compounds 1, 2, 3, 4, 5, 7, 9 showed significant activity, particularly 50...
Abstract Background Zhuyeqing Liquor (ZYQL), a well-known Chinese traditional health liquor, has various biological properties, including anti-oxidant, anti-inflammatory, immunoenhancement and cardiovascular protective effects. Methods The effects of (ZYQL) on the immune function was investigated in vivo normal healthy mice immunosuppressed treated with Cyclophosphamide (Cy, 100 mg/kg) by intraperitoneal injection days 4, 8 12. ZYQL (100, 200 400 administered via gavage daily for 14 days....
Abstract The study first evaluated the hepatoprotective effect of Zhuyeqing Liquor (ZYQL) against acute alcohol-induced liver injury in mice. Animals were administered orally with 50% alcohol 12 ml/kg at 4 h after doses ZYQL everyday for fourteen consecutive days except mice normal group. protective was by biochemical parameters including serum aspartate transaminase (AST), alanine transferase (ALT), total-bilirubin (TBIL) and reduced glutathione (GSH), malondialdehyde (MDA), superoxide...
Abstract Introduction – Ephedrine alkaloids cannot account for all the effects of Ephedra sinica and polysaccharides are also demonstrated to be one main bioactive constituents E. . However, no work has been reported on analysis monosaccharide composition purified isolated from stem Objective To develop a rapid efficient capillary zone electrophoresis (CZE) method based pre‐column derivatisation with 1‐phenyl‐3‐methyl‐5‐pyrazolone simultaneous determination neutral acidic sugars Methodology...
Impaired heart function is the main reason for increased mortality of diabetes mellitus. Development drugs with cardioprotective effects against diabetic myocardiopathy would benefit patients diabetes. In this study, we tested Daming capsule (DMC), a traditional Chinese formula, on in streptozocin (STZ)-induced rats high fat-diet (HFD). DMC 100 mg/kg/d markedly decreased fasting blood glucose (FBG) and total cholesterol (TC), but did not affect triglycerides (TG) at 30 d. The rate (HR)...
Please cite this paper as: Wang F, Hu Q, Chen C‐H , Xu X‐S, Zhou C‐M, Zhao Y‐F, B‐H, Chang X, Huang P, Yang L, Liu Y‐Y, C‐S, Fan J‐Y, Zhang K, Li G‐Y, J‐H, Han J‐Y. The protective effect of cerebralcare granule ® on brain edema, cerebral microcirculatory disturbance and neuron injury in a focal ischemia rat model. Microcirculation 19: 260–272, 2012. Abstract Objective: purpose the present study was to explore effects CG after I /R. Methods: Male Sprague–Dawley rats were subjected right...
Caulophyllum robustum Maxim (CRM) is a Chinese folk medicine with significant effect on treatment of rheumatoid arthritis (RA). This study was designed to explore the spectrum-effect relationships between high-performance liquid chromatography (HPLC) fingerprints and anti-inflammatory effects CRM. Seventeen common peaks were detected by fingerprint similarity evaluation software. Among them, 15 identified Liquid Chromatography-Mass Spectrometry (LC-MS). Pharmacodynamics experiments conducted...