A5008570936- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Nitric Oxide and Endothelin Effects
- Platelet Disorders and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Valve Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic function and diabetes
- Heart Failure Treatment and Management
- Cell Adhesion Molecules Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammatory Biomarkers in Disease Prognosis
- Sepsis Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Tracheal and airway disorders
- Cardiovascular Issues in Pregnancy
- Multimedia Communication and Technology
- Pericarditis and Cardiac Tamponade
- Reliability and Agreement in Measurement
- Abdominal vascular conditions and treatments
- Potassium and Related Disorders
- Enzyme function and inhibition
- Ferrocene Chemistry and Applications
Juntendo University
2005-2024
Juntendo University Hospital
2015-2020
Toho University
2016
Tohoku University
2016
Sekisui Medical (Japan)
2016
Toho University Medical Center Sakura Hospital
2016
Juntendo University Urayasu Hospital
2009-2010
Queen Mary Hospital
2010
Chinese University of Hong Kong
2010
Hong Kong College of Technology
2010
Previous studies suggest that nitric oxide (NO) may modulate insulin-induced uptake of glucose in insulin-sensitive tissues. Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor NO synthase (NOS). We hypothesized a reduction ADMA would increase synthesis and thereby enhance insulin sensitivity.To test this hypothesis we used transgenic mouse which overexpressed human dimethylaminohydrolase (DDAH-I). The DDAH-I mice had lower plasma at all ages (22 to 70 wk) by comparison wild-type...
Bone marrow stromal cells (BMSCs) have many characteristics of mesenchymal stem that can differentiate into smooth muscle (SMCs). However, there been few studies closely following the cell development lineage among BMSCs.To investigate possible existence a population committed to SMC bone adhesion cells, we tried detect and follow in vitro differentiation such type by using promoter-sorting method with human SM22alpha promoter (-480 bp)/green fluorescent protein (GFP) construct. The...
The contemporary outcome of balloon pulmonary angioplasty (BPA) and endarterectomy (PEA) in patients with chronic thromboembolic hypertension (CTEPH) are unclear.
Platelet adhesion on components of the extracellular matrix and platelet activation by those are crucial for arrest posttraumatic bleeding, but they can also harm tissue occluding diseased vessels. Recent studies have shown that platelets collagen is mediated through same pathway used immune receptors, with an immunoreceptor tyrosine-based motif Fc receptor gamma chain (FcRgamma) playing a pivotal role.We examined role collagen-stimulated in development injury-induced neointimal formation...
Cholinergic angiogenesis is mediated by an endothelial nicotinic acetylcholine receptor (EC nAChR). Short-term administration of nicotine stimulates via EC nAChRs.The long-term effects upon cholinergic are unknown. The objective this study was to determine whether chronic exposure blunts angiogenesis. We exposed C57/Bl6 male mice ( n = 42) (200 μg/ml drinking water) or vehicle for 8 16 weeks. Subsequently, hindlimb ischemia induced ligation the left femoral artery. After surgery, animals in...
Calcified amorphous tumour is a rare, non-neoplastic, endocardially based, intracavitary cardiac mass. This report describes 59-year old man in whom mobile mass was found incidentally the heart by routine echocardiography after he had been on haemodialysis for 3 years. Transoesophageal revealed high-echoic swinging that originated from annulus of anterior commissure mitral valve. Surgical resection performed to prevent embolization, and his clinical course excellent.
The present study compared short- and long-term prognostic values of red blood cell distribution width (RDW) with those hemoglobin (Hgb) among patients acute congestive heart failure (CHF) in a cardiac care unit. cross-sectional examined data from 521 CHF who were admitted to unit followed up for 24 months (median). Mean Hgb levels succumbed (DIH) or remained alive (AIH) 11.0±1.8 11.8±2.6 g/l (P>0.05), respectively. Median RDW 16.2% 14.4%, respectively (P<0.0001). During the 24-month...
Remodelling of pulmonary arteries (PA) contributes to the progression hypertension (PH). Periostin, a matricellular protein, has been reported be involved in development PH. We examined role periostin pathogenesis PH using different types experimental
Cardiovascular disease (CVD) is a leading cause of death in Japan. The present study aimed to develop new risk prediction models for long-term risks all-cause and cardiovascular patients with chronic phase CVD. Among the subjects registered BioBank Japan database, 15,058 aged ≥40 years ischemic CVD (ischemic stroke or myocardial infarction) were divided randomly into derivation cohort (n = 10,039) validation 5019). These followed up 8.55 median. Risk developed using by Cox proportional...
We aimed to determine whether LR11 (low-density lipoprotein receptor with 11 binding repeats) is a potential key regulator of smooth muscle cell (SMC) proliferation during the progression hypoxia-induced medial thickening in mice and sLR11 (soluble LR11) can serve as biomarker patients pulmonary arterial hypertension.The role hypertension was investigated using mouse models induced hypoxia. The expression hypoxia-inducible factor-1α significantly increased lung tissues from C57Bl/6 after 3...
Relative changes in B-type natriuretic peptide (BNP) and amino terminal pro-BNP (NT-proBNP) levels may help to assess the risk of congestive heart failure (CHF). However, whether these at time admission enable prediction outcomes with acute exacerbation remains unknown. The current study determined abilities BNP, NT-proBNP their ratio predict in-hospital long-term patients CHF. Patients who were admitted cardiac care unit Juntendo University Hospital (Tokyo, Japan) CHF onset consecutively...
The first case was a 68-year-old woman who had acute migratory pain from back to anterior chest and the second 66-year-old man with cardiac tamponade. Two cases were demonstrated low density area of left ventricular postero-lateral wall conventional contrast-enhanced computed tomography (CE-CT) performed differentiate diagnosis coronary syndrome aortic dissection. Subsequent angiograms showed lesions circumflex. These early contrast-defect corresponded decreased myocardial blood flow AMI....
Aim: Pneumococcal and influenza infections can cause serious morbidity mortality in patients with cardiovascular diseases. The purpose of this study was to investigate the safety efficacy simultaneous inoculations 23-valent pneumococcal polysaccharide vaccine (PPSV23) trivalent (TIV) coronary artery disease (CAD).
The aim of the present study was to determine long-term outcomes bifurcation lesions following a rotational atherectomy (ROTA). In this retrospective study, patients that had undergone ROTA coronary in Juntendo University Hospital (Tokyo, Japan) were enrolled between January 2007 and December 2009, received follow‑up for median duration 48 months (range, 12‑84 months). A total 337 enrolled. Each patient treated with an average 1.2±0.4 burrs (mean size, 2.9±0.3 mm). Baseline lesion length,...
The patient was a 73-year-old man with history of hypertension, diabetes mellitus, dyslipidemia, rheumatoid arthritis, repeated percutaneous coronary intervention and peripheral procedures. He frequently admitted to our hospital for congestive heart failure orthopnea. myocardial washout rate iodine-123-β-methyl iodophenyl-pentadecanoic acid defective on scintigraphy. diagnosed triglyceride deposit cardiomyovasculopathy (TGCV). Proton magnetic resonance spectroscopy (
The prognosis of pulmonary hypertension (PH) associated with connective tissue diseases related to interstitial pneumonia (CTD-IP PH) is relatively good among patients PH and lung disease. However, the impact vasodilator treatment on CTD-IP compared that PH-induced chronic disease (group-3 remains unclear. From 2012 2022, 50 parenchymal lesions diagnosed (mean arterial pressure >20 mmHg) at Juntendo University Hospital were divided into two groups: (30 patients) group 3-PH (20 patients). use...
Abstract Background Pulmonary hypertension (PH) is a right heart failure disease and can be fatal. Parathyroid hormone (PTH) bone metabolism regulates calcium phosphorus homeostasis. Previous studies have suggested that PTH affects the cardiovascular system influences diseases. We hypothesized may play role in pathogenesis of PH. Purpose This study aimed to investigate whether has critical pulmonary hemodynamics. Method Serum levels were measured patients with PH or suspected undergoing...
Background Heart failure is a severe condition often involving pulmonary hypertension (PH). Soluble low-density lipoprotein receptor with 11 ligand-binding repeats (sLR11) has been associated artery hypertension. We examined whether sLR11 correlates PH in left heart disease and can be used as predictive marker. Method retrospectively analyzed patients mitral regurgitation who underwent right catheterization before surgery for valve replacement or valvuloplasty from November 2005 to October...
Pulmonary artery hypertension (PAH) has been reported to be a severe adverse event associated with dasatinib therapy. Among the 76 chronic myeloid patients who were treated at our hospital, six showed high estimated pulmonary arterial systolic pressure, as observed by echocardiography. PAH was confirmed using right heart catheterization in three (3.9%) increased mean pressure (mPAP). In one patient, although mPAP higher than normal range, it did not fulfill criteria of hypertension. After...