A5080486400- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Cardiovascular Issues in Pregnancy
- Eicosanoids and Hypertension Pharmacology
- Connective tissue disorders research
- Blood Coagulation and Thrombosis Mechanisms
- Macrophage Migration Inhibitory Factor
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Coronary Interventions and Diagnostics
- Ferroptosis and cancer prognosis
- Galectins and Cancer Biology
- Hormonal Regulation and Hypertension
- Circular RNAs in diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Moyamoya disease diagnosis and treatment
- Vascular Anomalies and Treatments
- RNA modifications and cancer
- Transplantation: Methods and Outcomes
- Eosinophilic Disorders and Syndromes
- Cerebrovascular and genetic disorders
- Cardiomyopathy and Myosin Studies
- Liver Disease Diagnosis and Treatment
Keio University
2017-2025
Keio University Hospital
2017-2024
Both osteopontin (OPN) and galectin-3 have been implicated in phagocytic clearance of dead cells reparative fibrosis during wound healing. CD206+ macrophages are involved tissue repair through phagocytosis after myocardial infarction (MI). However, the relationship among OPN, galectin-3, macrophage polarization context MI remains unclear.The time course Spp1 (encoding OPN) expression heart showed a strong activation on day 3 MI. To identify where body which transcriptional activity increased...
The membrane components of cardiomyocytes are rich in polyunsaturated fatty acids, which easily oxidized. Thus, an efficient glutathione-based lipid redox system is essential for maintaining cellular functions. However, the relationship between disruption during ischemia-reperfusion (IR), oxidized production, and consequent cell death (ferroptosis) remains unclear. We investigated mechanisms underlying glutathione-mediated reduction related to ferroptosis IR developed intervention strategies...
We report a case of pregnancy following lung transplantation (LT) for idiopathic pulmonary arterial hypertension (IPAH) in Japan. A female developed IPAH at 14 years age and underwent successful bilateral living-donor lobar LT from her parents 19 (gravida 2, para 0). At the 40 years, patient became pregnant via artificial insemination. 28 weeks gestation, polyhydramnios fetal goiter were detected on transabdominal ultrasound. The was diagnosed with deep vein thrombosis embolism. emergency...
The contemporary outcome of balloon pulmonary angioplasty (BPA) and endarterectomy (PEA) in patients with chronic thromboembolic hypertension (CTEPH) are unclear.
Background We previously reported that osteopontin plays an essential role in accelerating both reparative fibrosis and clearance of dead cells (efferocytosis) during tissue repair after myocardial infarction (MI) galectin-3hiCD206+ macrophages is the main source post-MI heart. Interleukin-10- STAT3 (signal transducer activator transcription 3)-galectin-3 axis for Spp1 (encoding osteopontin) transcriptional activation cardiac MI. Here, we investigated more detailed mechanism responsible...
The benefits of inhaling hydrogen gas (H2) have been widely reported but its pharmacokinetics not yet sufficiently analyzed. We developed a new experimental system in pigs to closely evaluate the process by which H2 is absorbed lungs, enters bloodstream, and distributed, metabolized, excreted. inserted secured catheters into carotid artery (CA), portal vein (PV), supra-hepatic inferior vena cava (IVC) allow repeated blood sampling performed bilateral thoracotomy collapse lungs. Then, using...
The ring finger protein 213 gene (RNF213) encodes a 590 kDa that is thought to be involved in angiogenesis. This was first recognized as vasculopathy-susceptibility locus through genome-wide association studies undertaken Japanese population, demonstrating heterozygotes for RNF213 p.Arg4810Lys (c.14429G>A, rs112735431) had greatly increased risk of moyamoya disease. susceptibility variant disease reproduced Korean and Chinese individuals and, later, Caucasians. Variants the have been linked...
Failure of the right ventricle plays a critical role in any type heart failure. However, mechanism remains unclear, and there is no specific therapy. Here, we show that predominantly expresses alternative complement pathway-related genes, including Cfd C3aR1. Complement 3 (C3)-knockout attenuates ventricular dysfunction fibrosis mouse model C3a produced from C3 by convertase complex, which includes essential component factor D (Cfd). Cfd-knockout mice also attenuation Moreover, plasma...
Despite the ever-increasing complexity of percutaneous coronary intervention (PCI), incidence, predictors, and in-hospital outcomes catheter-induced artery dissection (CICAD) is not well defined. In addition, there are little data on whether persistent flow impairment after CICAD will affect clinical outcomes. We evaluated 17,225 patients from 15 participating hospitals within Japanese PCI registry January 2008 to March 2016. Associations between adverse cardiovascular events were using...
Dasatinib-related pulmonary arterial hypertension is a rare complication of chronic therapy for hematological malignancies. Pulmonary often persists despite drug discontinuation and might require vasodilators. Normalizing hemodynamics avoiding the long-term use vasodilators challenging. Patient was 55-year-old Japanese man complaining progressive dyspnea on effort fatigue. He had history myeloid leukemia treated with dasatinib. diagnosed dasatinib-related by right heart catheterization at...
Abstract Pulmonary hypertension is a fatal rare disease that causes right heart failure by elevated pulmonary arterial resistance. There an unmet medical need for the development of therapeutics focusing on vascular remodeling. Bioactive lipids produced perivascular inflammatory cells might modulate Here, we show ω-3 fatty acid-derived epoxides (ω-3 epoxides) released from mast PAF-AH2, oxidized phospholipid-selective phospholipase A2, negatively regulate hypertension. Genetic deletion...
Background: The evidence regarding triple oral combination therapy for patients with pulmonary arterial hypertension (PAH) is scarce. This study was performed to investigate the effectiveness and safety of macitentan, riociguat, selexipag. Methods: Among consecutive PAH who were referred our hospital from 2009 2020, those underwent using selexipag retrospectively analyzed. Hemodynamic echocardiographic assessments Kaplan–Meier analyses all-cause death initiation prostacyclin infusion...
Background Recently, some studies reported the pulmonary artery hypertension (PAH)-associated genes. However, a majority of patients with familial or sporadic PAH lack variants in known pathogenic In this study, we investigated new causative gene associated PAH. Methods and Results Whole-exome sequencing 242 Japanese identified heterozygous substitution change involving c.226G>A (p.Gly76Ser) tumor necrotic factor receptor superfamily 13B (TNFRSF13B) 6 (2.5%) patients. TNFRSF13B controls...
Genetic backgrounds of patients with pulmonary arterial hypertension (PAH) were not fully investigated. A variant c.14429G > (p.Arg4810Lys) in the ring finger protein 213 gene (RNF213) was recently identified as a risk allele for poor treatment response and clinical prognosis PAH. However, molecular mechanisms RNF213 p.Arg4810Lys development PAH are unknown. We investigated underlying RNF213-associated vasculopathy using an vivo mouse model. RNF213+/p.Arg4828Lys mice, harboring heterozygous...
Background The cause of chronic thromboembolic pulmonary hypertension (CTEPH) remains largely unknown. Recently, clonal hematopoiesis (CH) has been reported to be associated with cardiovascular and diseases. Here, we investigated the prevalence clinical impact CH in patients CTEPH. Methods Results Whole‐exome sequencing deep‐panel were performed 214 Clinical data before after treatment compared between without CH. RNA serum analysis explore pathogenesis that contributes Among enrolled...