A5075349479- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Granular flow and fluidized beds
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Fluid Dynamics and Heat Transfer
- Particle Dynamics in Fluid Flows
- Pulmonary Hypertension Research and Treatments
- Receptor Mechanisms and Signaling
- Lattice Boltzmann Simulation Studies
- Nitric Oxide and Endothelin Effects
- Complement system in diseases
- Heart Failure Treatment and Management
- Mitochondrial Function and Pathology
- Vitamin C and Antioxidants Research
- Cardiac Imaging and Diagnostics
- Landslides and related hazards
- Blood Coagulation and Thrombosis Mechanisms
- Viral Infections and Immunology Research
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
Kyorin University Hospital
2025
Mita Hospital
2021-2024
National Defense Medical College
2012-2022
National Defense Medical College Hospital
2020
Keio University
2007-2011
Osaka University
2008-2010
Keio University Hospital
2009
The purpose of diagnosing arrhythmia is to improve symptoms, quality life (QOL), and prognosis by preventing sudden cardiac death that caused fatal ventricular arrhythmias. Organic heart disease, such as myocardial infarction, accounts for the majority etiologies, whereas inherited diseases, Brugada syndrome, are also involved. Risk assessment using various test methods can help prevent a certain degree. Syncope precursor death, diagnosis arrhythmic syncope lead prevention death....
Disorders of L-type Ca2+ channels can cause severe cardiac arrhythmias. A subclass small GTP-binding proteins, the RGK family, regulates current (I(Ca,L)) in heterologous expression systems. Among these Rad (Ras associated with diabetes) is highly expressed heart, although its role heart remains unknown. Here we show that overexpression dominant negative mutant (S105N) led to an increase I(Ca,L) and action potential prolongation via upregulation channel plasma membrane guinea pig ventricular...
Left ventricular (LV) diastolic dysfunction is considered the main cause of heart failure with preserved ejection fraction (HFpEF). There have been few reports on correlation between LV and arterial stiffness in patients clinical cardiovascular disease.
Failure of the right ventricle plays a critical role in any type heart failure. However, mechanism remains unclear, and there is no specific therapy. Here, we show that predominantly expresses alternative complement pathway-related genes, including Cfd C3aR1. Complement 3 (C3)-knockout attenuates ventricular dysfunction fibrosis mouse model C3a produced from C3 by convertase complex, which includes essential component factor D (Cfd). Cfd-knockout mice also attenuation Moreover, plasma...
The World Health Organization recognizes digital health as a key driver for sustainable systems. Digital is broad concept that refers to the use of technologies improve and healthcare. Mobile part mobile devices such smartphones, tablets, wearable gadgets deliver health-related services. By proactively utilizing personal records from mHealth, in conjunction with electronic records, advanced medical practices can be achieved. This integration facilitates app-based patient education...
Insulin signaling comprises 2 major cascades: the insulin receptor substrate/phosphatidylinositol 3'-kinase/protein kinase B and Ras/Raf/mitogen-activated protein kinase/kinase/ERK pathways. While many studies on tissue-specific effects of 3' -kinase/protein pathway have been conducted, role other cascade in resistance has not investigated. High glucose/fatty acid toxicity, inflammation, oxidative stress, all which are associated with resistance, can activate ERK. The liver plays a central...
The management of chronic disseminated intravascular coagulation (DIC) caused by aortic dissection has not yet been established. Even in cases where surgical correction is performed, therapeutic control systemic hemorrhaging still required. We herein report the successful treatment a case with patent false lumen using tranexamic acid for acute exacerbation DIC. Oral administration 1,500 mg per day stabilized coagulative and fibrinolytic parameters relieved bleeding tendencies no side...
Oxidative posttranslational modifications (OPTM) impair the function of Sarcoplasmic/endoplasmic reticulum (SR) calcium (Ca
Purulent pericarditis is a rare disease in the antibiotic era. The common pathogens of purulent are gram-positive species such as Staphylococcus aureus. Streptococcus pneumoniae, Salmonella, Haemophilus, fungal pathogens/tuberculosis can also result pericarditis. We report an old male case by Escherichia coli. He came to our hospital suffering from leg edema for 3 months. Echocardiography revealed large amount pericardial effusion, and he was admitted test cause effusion without high fever,...
There is a gradual progression from paroxysmal to persistent atrial fibrillation (AF) in humans. To elucidate the mechanism involved, creation of an artificial substrate persist AF mice was attempted.
Abstract The patient was a 78‐year‐old man. In August 2007, he underwent catheter ablation for atrial fibrillation after taking bepridil 3 weeks. Soon the ablation, experienced frequent extrasystoles and began again on day left hospital. Six days discharge, readmitted to our hospital with dyspnea diagnosed acute heart failure. had no recurrence of fibrillation, so administration stopped. His eased using standard therapy failure discharged from March 2011, initiated defibrillate fibrillation....
Background: Cardiac cachexia is known to have poor prognosis. On the other hand, it has been reported recently that low level of branched-chain amino acids (BCAA) was related prognosis heart failure (HF). We examined relationship between BCAA and lean obese patients with HF. Method: enrolled 60 hospitalized HF (69 ± 11years). All were divided into 2 groups, group (BMI 26 5) 19 2) according median BMI, each groups level. The primary outcome defined as all-cause death, cardiovascular death...
The chronic oral toxicity of propiverine hydrochloride(P-4), a new anti-pollakiuria agent, was studied in beagle dogs. Groups 6 males and females were treated with P-4 at doses 0, 0.3, 1, 3, 9 mg/kg/day for one year thereafter 2 animals both sexes each group placed on withdrawal month. During administration recovery period, no death occured any dosed animals. As toxic sign, only the frequency vomitting increased 3 groups. Body weight, food water consumption not affected by administration. In...
Acute toxicity studies of propiverine hydrochloride (P-4) were carried out in mice, rats and dogs both sexes. 1. The LD50 values P-4 as follows : Mice ; 410(male) 323(female) mg/kg oral route, 223(male) 283(female) subcutaneous route 36(male female) intravenous Rats 1000(male) 1092(female) 1632(male) 1411(female) 22(male) 25(female) route. On the values, no sexual difference was apparent but species between mice observed to be present routes. approximate lethal doses 987-1137 for male...