A5024681131- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cervical Cancer and HPV Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Syncope and Autonomic Disorders
- TGF-β signaling in diseases
- Respiratory Support and Mechanisms
- School Health and Nursing Education
- Cancer-related molecular mechanisms research
- Alcohol Consumption and Health Effects
- Neonatal Respiratory Health Research
- Heart Rate Variability and Autonomic Control
- Cell Adhesion Molecules Research
- Muscle activation and electromyography studies
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Cardiomyopathy and Myosin Studies
- Lymphoma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Viral-associated cancers and disorders
- Cardiovascular Function and Risk Factors
- Antimicrobial Peptides and Activities
The University of Tokyo
2022-2025
Toyohashi Heart Center
2018-2025
GlaxoSmithKline (United Kingdom)
2009-2015
GlaxoSmithKline (Japan)
2006-2014
National Defense Medical College
2012
[Figure: see text].
Cardiovascular disease (CVD) and chronic obstructive pulmonary (COPD) commonly coexist share common risk factors. The prevalence of COPD in outpatients with a smoking history CVD Japan is unknown. aim this study was to determine the proportion Japanese patients being treated for who have concurrent airflow limitation compatible COPD. A secondary objective test whether usage lung function tests performed clinic influenced diagnosis rate identified limitation.In multicenter observational...
This study sought to systematically evaluate the ability of a high-resolution mapping system (Rhythmia, Boston Scientific, Marlborough, Massachusetts) rapidly and accurately localize residual endocardial epicardial conduction after mitral isthmus (MI) ablation, facilitating MI block. Achieving block across is challenging. Fifty consecutive patients undergoing ablation pulmonary vein isolation were enrolled. After initial radiofrequency (RF) lateral MI, activation with simultaneous coronary...
ABSTRACT Homologous recombination deficiency (HRD) tests, including MyChoice CDx, are companion diagnostics for poly (ADP‐ribose) polymerase (PARP) inhibitors. BRCA1 promoter hypermethylation, a major HRD cause, may correlate with poorer prognosis. This study aimed to develop simple, accurate method detecting hypermethylation and elucidate the characteristics of such cases. methylation was analyzed using bisulfite sequencing (BIS‐seq) in high‐grade serous ovarian carcinoma specimens. We...
Abstract Background Treatment of atrial tachycardia (AT) involving epicardial conduction remains challenging. While the endocardial breakthrough sites can be targets for radiofrequency (RF) ablation, that approach is sometimes ineffective and lead to treatment failure. Purpose This study aimed retrospectively evaluate effectiveness ablation at entrance site circuit ATs identified with entrainment. Methods Six cases (ATs) after fibrillation (AF) were studied, which diagnosed involve based on...
Abstract Background Bachmann's bundle pacing (BBp), which features a morphology similar to sinus rhythm (SR) and shortened P-wave duration (PWD), was reported significantly reduce the incidence permanence of atrial fibrillation compared with right appendage (RAAp). The development catheter-delivering system using lumenless lead from Medtronic has facilitated implantation (RA) septal pacing, including BBp, prompting renewed interest in physiological pacing. method BBp not been established, we...
Recent advances in fibrosis biology have identified transforming growth factor (TGF)-beta type I receptor-mediated activation of Smads as playing a central part the development fibrosis. However, to date, there been few studies that examined localisation and distribution receptor-activated protein (R-Smads: Smad2 3) during progression.To histopathologically assess time-course change pulmonary fibrosis.Pulmonary was induced by intranasal injection bleomycin (0.3 U/mouse). Lungs were isolated...
The in vivo conversion ratio of <i>N</i><sup>1</sup>-methylnicotinamide (NMN) to <i>N</i><sup>1</sup>-methyl-2-pyridone-5-carboxamide (2-PY) and <i>N</i><sup>1</sup>-methyl-4-pyridone-3-carboxamide (4-PY) as a parameter for the estimation aldehyde oxidase level rats was examined. NMN its pyridones (2-PY 4-PY) are usually detected urine rats. When we measured amount total (RP value) rats, marked intraspecies variations were observed. variation RP value among strains closely related...
Background: A large number of chronic obstructive pulmonary disease (COPD) patients in Japan remain undiagnosed, primarily due to the underuse spirometry. Two studies were conducted see whether COPD Assessment Test (CAT) primary care has potential identify those who need spirometry for a diagnosis and determine with cardiovascular had airflow limitation, which could be detected by CAT. Materials methods: multicenter, noninterventional, prospective (studies 1 2) across Japan. Patients both...
Abstract Human papillomavirus 18 (HPV18) is a highly malignant HPV genotype among high‐risk HPVs, characterized by the difficulty of detecting it in precancerous lesions and its high prevalence adenocarcinomas. The cellular targets molecular mechanisms underlying infection remain unclear. In this study, we aimed to identify cells targeted HPV18 elucidate replication. Initially, established lentiviral vector (HPV18LCR‐GFP vector) containing long control region promoter located upstream EGFP ....
Loss of heterozygosity (LOH) has been reported to occur in HLA regions cervical intraepithelial neoplasia (CIN) and cancer. However, the details how this is related progression CIN have unclear. In study, we examined human papillomavirus (HPV) antigen-presenting capacity people with significance LOH class I CIN. It was shown that differences among each case depended on types, not HPV genotypes. Focusing type, there a positive correlation between against frequency allelic loss. Furthermore,...
We examined the prevalence of chronic obstructive pulmonary disease (COPD) diagnosed and at-risk status, public awareness COPD among adults in Japan, as well respondent characteristics health outcomes compared with controls.Regression models used 2012 National Health Wellness Survey Japan data to compare COPD-diagnosed, at-risk, healthy (aged ≥18) on demographics, behaviors, health-related quality life (HRQoL), productivity healthcare resource use.Among n = 29,978 respondents, was 0.9%;...
Abstract The patient was a 78‐year‐old man. In August 2007, he underwent catheter ablation for atrial fibrillation after taking bepridil 3 weeks. Soon the ablation, experienced frequent extrasystoles and began again on day left hospital. Six days discharge, readmitted to our hospital with dyspnea diagnosed acute heart failure. had no recurrence of fibrillation, so administration stopped. His eased using standard therapy failure discharged from March 2011, initiated defibrillate fibrillation....
Key Teaching Points•Left bundle branch area pacing (LBBAP) for Ebstein's anomaly is possible with deep lead fixation from a functional right atrium.•Using 9F coronary sinus left ventricular delivery sheath and C315 His catheter as sheath-in-sheath technique can be safe effective in LBBAP.•The useful to provide adequate backup even if the has reached site. •Left
Abstract Background/Introduction Injury to the sinus node artery (SNA) leading SN dysfunction during radiofrequency catheter ablation (RFCA) of atrial Fibrillation (AF) and tachycardia (AT) has been reported. Purpose The purpose this study was elucidate prevalence clinical course SNA injuries RFCA AF/AT examine efficacy percutaneous coronary intervention (PCI) restore function. Methods We retrospectively analyzed data from 6,906 consecutive patients (pts) who underwent (6,379 pts with AF 527...
Abstract Introduction Although atrial septal pacing has been reported to reduce fibrillation (AF) burden, there is less evidence regarding its effect on the prevention of permanent AF and improvement long-term clinical outcomes. However, Bachmann's bundle (BBp), which features P-wave morphology similar sinus rhythm shortened duration (PWD), was significantly recurrences occurrences compared with right appendage (RAAp) non-specific pacing. Purpose Possible mechanisms for suppression BBp are...
Patients with cervical cancer benefiting from immune checkpoint inhibitors (ICIs) are limited. Recently, PD-L1 amplification has been attracted attention as a reliable marker of ICIs. A 47-year-old woman stage IIB experienced disease progression during postoperative adjuvant chemotherapy. Cancer genomic profiling revealed that the tumor was microsatellite stable amplification, therefore, nivolumab administered by enrolling in BELIEVE trial. Despite treatment, remarkable observed. At...
Abstract Funding Acknowledgements Type of funding sources: None. Background His-bundle pacing (HBP) and left bundle branch area (LBBAP) have been popular as physiological procedures and, according to previous reports, both can decrease heart failure admission preserve ventricular ejection fraction compared right pacing. In general, the has different thresholds (e.g. or myocardium), but automatic capture management cannot diagnose these multiple adjustments output based on threshold tests may...
Since Deshmukh and associates1 reported the successful implementation of His-bundle pacing (HBP) in 2000, previous studies have that HBP can decrease heart failure admission preserve left ventricular ejection fraction compared to right (RV) pacing.2,3