A5032033606- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Heat shock proteins research
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Signaling Pathways in Disease
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- FOXO transcription factor regulation
- Metastasis and carcinoma case studies
- Cancer, Hypoxia, and Metabolism
- CNS Lymphoma Diagnosis and Treatment
- Machine Learning in Materials Science
- PI3K/AKT/mTOR signaling in cancer
Chiba Cancer Center
2021-2025
National Cancer Centre Japan
2022-2025
Tokyo National Hospital
2021
National Cancer Center
2021
Yokohama City University
2019-2020
The University of Tokyo
2008-2019
Tokyo Medical University
2018-2019
University of Split
2016
The University of Queensland
2016
Ontario Institute for Cancer Research
2011
ABSTRACT The establishment of an optimal noninvasive method for diagnosing invasive aspergillosis (IA) is needed to improve the management this life-threatening infection in patients with hematological disorders, and a number tests IA that target different fungal components, including galactomannan, (1→3)-β- d -glucan (BDG), Aspergillus DNA, have been developed. In study, we prospectively evaluated diagnostic potential three were used weekly screening strategy: double-sandwich enzyme-linked...
Estrogen is a key regulator of normal function female reproductive system and plays pivotal role in the development progression breast cancer. Here, we demonstrate that JMJD2B (also known as KDM4B) constitutes component estrogen signaling pathway. expressed high proportion human tumors, expression levels significantly correlate with receptor (ER) positivity. In addition, 17-beta-estradiol (E2) induces an ERα dependent manner. interacts components SWI/SNF-B chromatin remodeling complex....
Members of the RAS superfamily small guanosine triphosphatases (GTPases) transition between GDP-bound, inactive and GTP-bound, active states thereby function as binary switches in regulation various cellular activities. Whereas HRAS, NRAS, KRAS frequently acquire transforming missense mutations human cancer, little is known oncogenic roles other GTPases, including Ras-related C3 botulinum toxin substrate (RAC) proteins. We show that sarcoma cell line HT1080 harbors both NRAS(Q61K) RAC1(N92I)...
ASXL1 mutations occur frequently in myeloid neoplasms and are associated with poor prognosis. However, the mechanisms by which mutant induces leukaemogenesis remain unclear. In this study, we report mutually reinforcing effects between a C-terminally truncated form of (ASXL1-MT) BAP1 promoting leukaemogenesis. expression results increased monoubiquitination ASXL1-MT, turn increases catalytic function BAP1. This hyperactive ASXL1-MT/BAP1 complex promotes aberrant differentiation...
Uterine adenomyosis is a benign disorder that often co-occurs with endometriosis and/or leiomyoma, and impairs quality of life. The genomic features are unknown. Here we apply next-generation sequencing to (70 individuals 192 multi-regional samples), as well co-occurring leiomyoma endometriosis, find recurring KRAS mutations in 26/70 (37.1%) cases. Multi-regional reveals oligoclonality adenomyosis, some also detected normal endometrium endometriosis. more frequent cases low progesterone...
This study performed a comprehensive molecular characterization of microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) gastrointestinal (GI) tumors to elucidate predictors response PD-1 blockade.Forty-five patients with MSI-H/dMMR GI tumors, including gastric cancer, colorectal cholangiocarcinoma, small intestine pancreatic and duodenal receiving blockade were analyzed. We conducted the genomic profiling by whole-exome sequencing or targeted next-generation sequencing....
Abstract Purpose: Transcriptomic profiling was performed for microsatellite instability-high (MSI-H)/mismatch repair-deficient (dMMR) gastrointestinal tumors to determine the predictors of response PD-1 blockade. Experimental Design: Thirty-six patients with MSI-H/dMMR tumors, including gastric cancer, colorectal cholangiocarcinoma, small intestine and pancreatic being treated blockade were analyzed. We conducted transcriptomic analysis using RNA sequencing data, consensus molecular subtypes...
This is a phase I/II trial to assess the efficacy and safety of napabucasin plus pembrolizumab for metastatic colorectal cancer (mCRC).Phase I was conducted determine recommended 2 dose (RP2D) in escalation design (240 480 mg twice daily) with 200 every 3 weeks. Phase II included cohort A (n = 10, microsatellite instability high, MSI-H) B 40, stable, MSS). The primary endpoint immune-related objective response rate (irORR). PD-L1 combined positive score (CPS), genomic profiles, consensus...
Purpose: The advent of next-generation sequencing technologies has enabled the identification several activating mutations Erb-B2 receptor tyrosine kinase 2 (ERBB2) among various cancers. However, significance infrequent not been fully investigated. Herein, we comprehensively assessed functional ERBB2 in a high-throughput manner.Experimental Design: We evaluated transforming activities and drug sensitivities 55 nonsynonymous using mixed-all-nominated-in-one (MANO) method.Results: G776V,...
Background Patients with cancer benefit from treatment immune checkpoint inhibitors (ICIs), and those an inflamed tumor microenvironment (TME) and/or high mutation burden (TMB), particularly, tend to respond ICIs; however, some patients fail, whereas others acquire resistance after initial response despite the TME TMB. We assessed detailed biological mechanisms of ICIs such as programmed death 1 cytotoxic T-lymphocyte-associated protein 4 blockade therapies using clinical samples. Methods...
Abstract Transcription factor AML1/Runx1, initially isolated from the t(8;21) chromosomal translocation in human leukemia, is essential for development of multilineage hematopoiesis mouse embryos. AML1 negatively regulates number immature hematopoietic cells adult hematopoiesis, whereas it required megakaryocytic maturation and lymphocytic development. However, remains yet to be determined how contributes homeostasis stem (HSCs). To address this issue, we analyzed detail HSC function absence...
Abstract Purpose: Colorectal cancers with microsatellite instability–high (MSI-H) status, due to mismatch repair deficiency, are associated poor patient outcomes after relapse. We aimed identify novel therapeutic targets for them. Experimental Design: performed MSI analyses of over 2,800 surgically resected colorectal tumors obtained from consecutive patients treated in Japan 1998 through June 2016. Whole-exome sequencing, transcriptome and methylation were on 149 162 showing BAT25 BAT26...
Triple-negative breast cancer (TNBC) cells do not express estrogen receptors, progesterone or human epidermal growth factor receptor 2. Currently, apart from poly ADP-ribose polymerase inhibitors, there are few effective therapeutic options for this type of cancer. Here, we present comprehensive characterization the genetic alterations in TNBC performed by high coverage whole genome sequencing together with transcriptome and exome sequencing. Silencing BRCA1 gene impaired homologous...