A5051748580- Lung Cancer Treatments and Mutations
- Protein Tyrosine Phosphatases
- Synthesis and biological activity
- Cancer Immunotherapy and Biomarkers
- Metal Extraction and Bioleaching
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- Minerals Flotation and Separation Techniques
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Renal function and acid-base balance
- Supercapacitor Materials and Fabrication
- Gout, Hyperuricemia, Uric Acid
- Lymphoma Diagnosis and Treatment
- Electrodeposition and Electroless Coatings
- Metastasis and carcinoma case studies
- Corrosion Behavior and Inhibition
- Gastrointestinal disorders and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Cytokine Signaling Pathways and Interactions
- Metallurgical Processes and Thermodynamics
- Metal and Thin Film Mechanics
- Minimally Invasive Surgical Techniques
- Intraperitoneal and Appendiceal Malignancies
- Inflammatory Biomarkers in Disease Prognosis
Kindai University
2019-2025
Mayo Clinic in Arizona
2024-2025
Nihon University Itabashi Hospital
2017-2022
Shonan Institute of Technology
1998-2022
Kishiwada City Hospital
2022
Weatherford College
2022
Osaka Prefecture University
1990-2020
Tokushima University Hospital
2019
National Institute of Advanced Industrial Science and Technology
2019
Shizuoka University
2018
Implementation of personalized medicine requires the accessibility tumor molecular profiling in order to allow prioritization appropriate targeted therapies for individual patients. Our aim was study role comprehensive genomic assays that may inform treatment recommendations patients with solid tumors.
Abstract Purpose: Treatment with KRASG12C inhibitors such as sotorasib can produce substantial regression of tumors in some patients non–small cell lung cancer (NSCLC). These require alternative treatment after acquiring resistance to the inhibitor. The mechanisms underlying this acquired are unclear. purpose study was identify resistance, and explore potential treatments for rescuing sotorasib-resistant NSCLC cells. Experimental Design: Clones sotorasib-sensitive H23 cells exposed different...
BackgroundCytokines have validated roles in the immunopathogenesis of inflammatory bowel disease (IBD). This study was to investigate expressions tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-8, and IL-10 mRNAs colonic mucosa patients with ulcerative colitis (UC) during active quiescent UC.
Introduction The clinical relevance of soluble forms programmed cell death-1 (sPD-1) and death-ligand 1 (sPD-L1) remains unclear. We here investigated the relation between efficacy PD-1 blockade pretreatment plasma levels sPD-1 sPD-L1 across a broad range cancer types. Methods retrospectively analyzed data from 171 patients with advanced solid tumors who received nivolumab or pembrolizumab monotherapy regardless treatment line. concentrations were measured fully automated immunoassay (HISCL...
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for their antipyretic, analgesic, and properties. However, various aspects of NSAID-induced lower gastrointestinal tract injury remain unclear, effective prophylaxis has not been established. Based on its pharmacological effect clinical trials, rebamipide may prevent injury, although this evidence is limited by the small scale trials. The present study FDA Adverse Event Reporting System (FAERS) Japanese Database (JADER) to assess...
Background: Combined chemotherapy with nivolumab and ipilimumab (NIC) improves survival outcomes in treatment-naïve patients advanced non-small cell lung cancer (NSCLC). However, these have a higher incidence of treatment-related deaths (TRDs) especially due to NIC. The aim this study is devise risk stratification score for selecting lower or TRD-risk. Methods: A dataset from the JCOG2007 used, which compared NIC combined pembrolizumab (PC). TRD was built an adaptive LASSO regression...
Abstract Background: Diffuse pleural mesothelioma (DPM) is a rare and aggressive cancer arising from mesothelial cells of the pleura. Over 2, 500 new cases are diagnosed annually in United States, mainly attributable to asbestos exposure. The prognosis poor, while nivolumab (PD-1 inhibitor) ipilimumab (CTLA-4 have been approved for first-line treatment unresectable DPM, three-year survival rate only 23%. DPM tumors express high levels epidermal growth factor receptor (EGFR)...
Immunotherapy has been shown to prolong survival in recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) front-line use; however, subsequent systemic therapy not optimized. This study aimed evaluate safety efficacy cetuximab-containing chemotherapy after immunotherapy. We retrospectively analyzed patients with SCCHN who underwent regimens progression on Of 22 met inclusion criteria, 21 received paclitaxel cetuximab, 1 carboplatin fluorouracil cetuximab Nine achieved a...
Background: Appropriate initial dosing of vancomycin (VCM) is important in improving survival and preventing nephrotoxicity critically ill patients, but the potential relationship between VCM trough levels early-onset remains unclear. We examined VCM-associated nephrotoxicity. Methods: performed a retrospective study patients who had therapeutic drug monitoring with within 4 days after beginning administration. excluded received renal replacement therapy from 2 before to 7 administration,...
IntroductionDespite a considerable benefit of adding immune checkpoint inhibitors (ICIs) to platinum-based chemotherapy for patients with extensive-stage SCLC (ES-SCLC), durable response ICIs occurs in only small minority such patients.MethodsA total 135 ES-SCLC treated either alone (chemo-cohort, n = 71) or together an ICI (ICI combo-cohort, 64) was included this retrospective study. Tumors were classified pathologically as inflamed noninflamed on the basis programmed death-ligand 1...
Abstract Medical oncologists are challenged to personalize medicine with scientific evidence, drug approvals, and treatment guidelines based on sequencing of clinical samples using next generation sequencer (NGS). Knowledge-based curation systems have the potential help address this challenge. We report here results examining level evidence regarding approval trials between recommendations made by Watson for Genomics (WfG), QIAGEN Clinical Insight Interpret (QCII), Oncomine knowledge-based...
Abstract Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are standard therapy for EGFR -mutant non-small cell lung cancer (NSCLC). Preclinically, HER3 ligand heregulin induces resistance to EGFR-TKIs, whereas the pan-human family inhibitor afatinib remains effective. Here, we examined whether soluble levels have clinical implications NSCLC treated with EGFR-TKIs. Soluble was immunologically measured in plasma from patients. Cutoff values were determined by 1-year PFS...
Azurin I from Alcaligenes xylosoxidans NCIMB 11015 (AzN-I) was crystallized by using PEG 4000 as a precipitant. The crystals belong to the monoclinic crystal system and have space group C 2 with unit-cell parameters of = 130.67, b 54.26, c 74.55 Å, β 95.99°. structure AzN-I has been solved molecular replacement method. II same bacterium (AzN-II) chosen initial structural model. final crystallographic R value is 17.3% free 23.6% for 10 958 reflections at resolution 2.45 Å. root-mean-square...
Effect of Impurities such as arsenic, antimony, bismuth and tin on the copper anode potential has been studied.By presence β-Cu3As in is extremely raised, but a large portion arsenic dissolves electrolyte to form or arsenious acid. The raise antimony containing caused by formation Sb2O3 (ortho) slime. Bismuth does not dissolve presents at grain boundaries. quite different depending Cl-ion. absence Cl-ion leads according slime formed reducing reaction bismuth. On contrary, it brings about...
This study was conducted to elucidate renal uric acid metabolism in patients with primary aldosteronism (PA; 16 cases) as compared normotensive subjects (NT; 25 and essential hypertensives (EHT; 51 cases).All were hospitalized received a regular diet (Na; 120 mEq,K; 75 mEq, daily) for more than two weeks, after which clearance tests performed, serum (SUA), fractional excretions of (FEUA), sodium (FENa), inorganic phosphorus (FEP) evaluated. Plasma aldosterone concentration (PAC) measured PA...
Currently, anti-TNFα antibodies are used to treat Crohn's disease. We report on a 45-year-old Japanese female with disease developing SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome following exposure the antibody adalimumab. Initially, adalimumab induced remission, but patient showed 11 weeks start of therapy for first time. Cutaneous articular involvement were exacerbating condition, so was discontinued put low-dose methotrexate control her symptoms. To our...