A5036465305- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Muscle Physiology and Disorders
- Breast Lesions and Carcinomas
- Colorectal Cancer Treatments and Studies
- Reproductive System and Pregnancy
- Genetic Neurodegenerative Diseases
- Reproductive Biology and Fertility
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Estrogen and related hormone effects
- Nutrition and Health in Aging
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Cancer-related Molecular Pathways
- Body Composition Measurement Techniques
- Endometriosis Research and Treatment
- Peptidase Inhibition and Analysis
- Neurogenetic and Muscular Disorders Research
- Brain Metastases and Treatment
- Neuroscience and Neuropharmacology Research
Osaka International Cancer Institute
2016-2025
Yokohama Rosai Hospital
2015-2024
Nihonkai General Hospital
2015-2024
Japan Hospital Association
2020
Nagasaki Rousai Hospital
2010-2020
Osaka National Hospital
1991-2019
Nihon University Itabashi Hospital
2019
Sapporo National Hospital
2019
National Cancer Center Hospital East
2016-2019
Saitama Cancer Center
2019
Human epidermal growth factor receptor 3 (HER3) is broadly expressed in breast cancer; high expression associated with an adverse prognosis. Patritumab deruxtecan (HER3-DXd) investigational HER3-targeted antibody-drug conjugate that being evaluated as a novel treatment HER3-expressing advanced cancer the U31402-A-J101 study.Adults disease progression on previous therapies were eligible. Patients dose-escalation, dose-finding, and dose-expansion parts received HER3-DXd 1.6-8.0 mg/kg...
Hyperuricemia has recently been recognized to be a risk factor for nephropathy in the diabetic subject. We tested hypothesis that lowering uric acid with xanthine oxidase inhibitor might reduce renal injury mouse. Diabetic (db/db) mice were treated allopurinol or no treatment 8 wk. Serum acid, function, and histology assessed at death. The direct effect of human proximal tubular epithelial cells was also evaluated under normal high glucose condition. found db/db developed hyperuricemia,...
Recent studies suggest that the metabolic syndrome is associated with renal disease. We previously reported a high-fructose diet, but not high-glucose can induce and accelerate chronic disease in rats. now examined effects of diet on normal rat kidneys. Three groups Sprague-Dawley rats were pair fed special containing 60% fructose, glucose, or control standard chow for 6 wk, then histological performed. The effect fructose to cell proliferation cultured proximal tubular cells was also...
The purpose of the present study was to investigate association glutathione S-transferase P1 (GSTP1) expression with resistance neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers. relationship GSTP1 and promoter hypermethylation intrinsic subtypes also investigated. In this study, primary cancer patients (n = 123, stage II-III) treated P-FEC were analyzed. Tumor samples obtained vacuum-assisted core biopsy before P-FEC. determined...
Adjuvant trastuzumab monotherapy has not been compared with + chemotherapy. We investigated the relative value of for older patients breast cancer.This study was an open-label, randomized controlled a treatment selection design in which noninferiority criterion predefined. Patients aged 70-80 years surgically treated human epidermal growth factor receptor 2-positive invasive cancer received or The primary end point disease-free survival (DFS) assessment prespecified hazard ratio (HR),...
1002 Background: Patritumab deruxtecan (HER3-DXd) is a novel, investigational ADC composed of human anti-HER3 monoclonal antibody covalently bound to topoisomerase I inhibitor payload via stable tetrapeptide-based cleavable linker. Here we report updated safety and efficacy data from this ongoing study (U31402-A-J101; NCT02980341; JapicCTI-163401) HER3-DXd in pts with previously treated MBC. Methods: U31402-A-J101 phase 1/2, multicenter, open-label, first-in-human HER3-expressing MBC (N =...
BACKGROUND: There are few effective approaches to infertile patients with repeated failure in IVF–embryo transfer therapy. Since recent evidence suggests that some populations of maternal immune cells positively support embryo implantation, we have developed a new approach using peripheral blood mononuclear (PBMCs). METHODS: Patients who had not experienced successful pregnancy despite four or more sessions were enrolled this study (n = 35, 35 cycles). PBMCs obtained from on the day oocyte...
Abstract BACKGROUND: The 21‐gene signature has been intensively studied and incorporated into major guidelines for treatment decision in early breast caner. However, it remains to be examined whether this system is applicable Asian populations. METHODS: authors collected 325 tumor tissues from estrogen receptor (ER)‐positive primary cancer patients who had undergone surgery were treated with tamoxifen between 1992 1998. analyzed the signature, classified groups of low, intermediate, or high...
The vascular endothelium expresses endothelial nitric oxide synthase (eNOS) that generates (NO) to help maintain integrity due its anti-inflammatory, antiproliferative, and antithrombogenic effects. Pharmacological blockade of NO production has been shown exacerbate renal injury in chronic disease induces cell loss. However, pharmacological inhibition nonspecifically blocks other types NOS therefore does not define the specific role eNOS kidney disease. We hypothesized a lack can induce loss...
We recently developed the one-step methylation-specific PCR (OS-MSP) assay which can detect methylated DNA (met-DNA) in serum with high sensitivity. To examine its prognostic value, we applied this new to detection of met-DNA breast cancer patients.Serum samples taken before surgery from 336 primary invasive patients were subjected OS-MSP for promoter regions GSTP1, RASSF1A, and RARβ2. The outcome was considered positive when methylation detected at least one these three genes. Total content...
This randomized, multicenter study compared the efficacy of docetaxel with or without capecitabine following fluorouracil/epirubicin/cyclophosphamide (FEC) therapy in operable breast cancer and investigated role Ki67 as a predictive biomarker. Patients were randomized to 4 cycles docetaxel/capecitabine (docetaxel: 75 mg/m2 on day 1; capecitabine: 1,650 days 1–14 every 3 weeks) alone (75 1 after completion FEC (5-fluorouracil 500 mg/m2, epirubicin 100 cyclophosphamide weeks). The primary...
Purpose: This study aimed to assess the efficacy of scalp-cooling devices in preventing chemotherapy-induced alopecia Japanese breast cancer patients and investigate whether a device improves hair volume recovery over 12 weeks period after completing chemotherapy. Methods: multicenter controlled trial included women with undergoing chemotherapy Japan between February 2016 March 2018. The primary endpoint was proportion no at end secondary Results: A total 48 were enrolled; them, 34 14...
Abstract Background A recent large real-world study conducted in the United States reported effectiveness of palbociclib plus aromatase inhibitor HR+/HER2− advanced breast cancer (ABC). However, local clinical practice and available medical treatment can vary between Japan Western countries. Thus, it is important to investigate Japanese data. This observational, multicenter (NCT05399329) reports interim analysis ET as first-line or second-line for ABC by estimating progression-free survival...
Deletions at 22q11.1–q11.2 present with variable manifestations usually referred to as DiGeorge or velo-cardio-facial syndrome. We previously reported that deletions observed in patients the syndrome can be subgrouped into three types (common large deletion, proximal and distal deletion) demonstrated presence of a second critical region for In order characterize further region, 22q11 deletion map was constructed from data 100 patients, using 12 DNA markers scattered common then...
The aim of this study was to investigate the role peripheral blood mononuclear cells (PBMC) in embryo invasion at implantation site and estimate effect on PBMC function human chorionic gonadotrophin (HCG) that is secreted from embryo.The invasiveness murine embryos examined using an assay. obtained women early pregnancy (5-9 weeks gestation) significantly enhanced both spreading Matrigel beneath gel. These effects were greater than those non-pregnant secretory phase (cycle day 16-24) control...
Abstract To investigate immune-endocrine interactions between the embryo and mother early in pregnancy, we examined effects of human chorionic gonadotropin (HCG) on IL-8 production by peripheral blood mononuclear cells (PBMC). Recombinant HCG promoted secretion PBMC derived from nonpregnant women. The induction mRNA expression was observed after 30 min stimulation. Adsorption with anti-HCG antibodies confirmed specificity this effect. translocation nuclear factor κB into nucleus subsequent...