A5029728563- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Biosensors and Analytical Detection
- Respiratory viral infections research
- Gastrointestinal motility and disorders
- Lung Cancer Treatments and Mutations
- Pneumonia and Respiratory Infections
- Pain Management and Opioid Use
- Pharmacy and Medical Practices
- Gastroesophageal reflux and treatments
- Cancer Genomics and Diagnostics
- Safe Handling of Antineoplastic Drugs
- Viral gastroenteritis research and epidemiology
- Lung Cancer Research Studies
- COVID-19 diagnosis using AI
- Intestinal and Peritoneal Adhesions
- Pancreatic and Hepatic Oncology Research
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical Practices and Patient Outcomes
- Dental Research and COVID-19
- Microbial infections and disease research
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Diet and metabolism studies
- Cancer therapeutics and mechanisms
Kindai University
2009-2023
Nara Medical University Hospital
2016-2023
Osaka Nishi Clinic
2021-2023
University of Tsukuba
2018-2023
Tsukuba Medical Center Hospital
2015-2023
University of Tsukuba Hospital
2021
The expression and activity of the epidermal growth factor receptor (EGFR) are determinants radiosensitivity in several tumour types, including non-small cell lung cancer (NSCLC). However, little is known whether genetic alterations EGFR NSCLC cells affect therapeutic response to monoclonal antibodies (mAbs) combination with radiation. We examined effects nimotuzumab, a humanised mAb EGFR, ionising radiation on human lines differing status. Flow cytometry revealed that H292 Ma-1 expressed...
IntroductionSeveral antigen tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed worldwide, but their clinical utility has not well established. In this study, we evaluated the analytical and performance of QuickNavi™-COVID19 Ag, a newly test in Japan.MethodsThis prospective observational study was conducted at PCR center between October 7 December 5, 2020. The included patients were referred from local public health 89 primary care facilities. We...
Abstract The clinical utility of antigen test using anterior nasal samples has not been well evaluated. We conducted a prospective study in drive-through testing site located at PCR center to evaluate the diagnostic performance QuickNavi-COVID19 Ag and compare degrees coughs or sneezes induction severity pain between collection nasopharyngeal collection. included total 862 participants, which 91.6% were symptomatic. median duration from symptom onset sample was 2.0 days. Fifty-one...
This multicenter, prospective, observational cohort study assessed opioid induced constipation (OIC) in Japanese patients with cancer. Eligible had stable cancer and an ECOG PS of 0-2. OIC incidence based on the Rome IV diagnostic criteria was determined by patient diary entries during first 14 days therapy. The proportion calculated for each 1-week period overall 2-week period. Secondary measurements included Bowel Function Index (BFI) score (patient assessment administered physician),...
Since respiratory sample collection is an uncomfortable experience, simultaneous detection of pathogens with a single swab preferable. We prospectively evaluated the clinical performance newly developed antigen test QuickNavi-Flu+COVID19 Ag (Denka Co., Ltd., Tokyo, Japan) which can detect severe acute syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses at same time testing device.We included those who were suspected contracting disease 2019 (COVID-19) referred to PCR center Ibaraki...
// Isamu Okamoto 1 , Kazuko Sakai 2 Satoshi Morita 3 Hiroshige Yoshioka 4 Hiroyasu Kaneda 5 Koji Takeda 6 Tomonori Hirashima 7 Yoshihito Kogure 8 Tatsuo Kimura 9 Toshiaki Takahashi 10 Shinji Atagi 11 Takashi Seto 12 Toshiyuki Sawa 13 Masashi Yamamoto 14 Miyako Satouchi 15 Motoyasu Okuno 16 Seisuke Nagase 17 Koichi Takayama 18 Keisuke Tomii 19 Tadashi Maeda 20 Oizumi 21 Fujii 22 Yusaku Akashi 23 Kazumi Nishino 24 Noriyuki Ebi 25 Kazuhiko Nakagawa Yoichi Nakanishi 1,18 and Kazuto Nishio Center...
Molecular tests are the mainstay of detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, their accessibility can be limited by long examination time and inability to evaluate multiple samples at once. This study evaluated analytical performance newly developed rapid molecular assays GENECUBE® HQ SARS-CoV-2 FLU A/B. prospective was conducted between 14 December 2020 9 January 2021 a polymerase chain reaction (PCR) center. Samples were collected from nasopharynx...
Antigen testing may help screen for and detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in asymptomatic individuals. However, limited data regarding the diagnostic performance of antigen tests this group are available.We used clinical samples to prospectively evaluate analytical test QuickNavi™-COVID19 Ag. This study was conducted at a PCR center between October 7, 2020 January 9, 2021. Two nasopharyngeal per patient were obtained with flocked swabs; one test,...
Abstract Background Mycoplasma pneumoniae is a common pathogen causing pneumonia; macrolide‐resistant strains are rapidly spreading across Japan. However, the clinical features of M. pneumonia have not been well established. Here, we evaluated characteristics and seasonal variations in prevalence with mutations ( MRM ). Methods The monthly isolated from May 2016 to April 2017 was retrospectively analyzed, cases were compared those without . isolates point at site 2063 or 2064 domain V 23S...
IntroductionRapid antigen tests are convenient for diagnosing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, they have lower sensitivities than nucleic acid amplification tests. In this study, we evaluated the diagnostic performance of Quick Chaser® Auto SARS-CoV-2, a novel digital immunochromatographic assay that is expected to higher sensitivity conventional tests.MethodsA prospective observational study was conducted between February 8 and March 24, 2021. We...
Background: Patients with adenocarcinoma of the lung are routinely screened for anaplastic lymphoma kinase (ALK) rearrangement because they can be treated by ALK-specific targeted therapy. The clinical and molecular characteristics large-cell neuroendocrine carcinoma (LCNEC) associated ALK still unclear. Herein, we assessed status in a series patients LCNEC testing methods commonly used adenocarcinoma. Materials Methods: expression was first examined immunohistochemistry. For positively...
Rapid identification of causative agents from positive blood culture media is a prerequisite for the timely targeted treatment patients with sepsis. The GENECUBE (TOYOBO Co., Ltd.) novel, fully-automated gene analyzer that can purify DNAs and amplify target DNAs. In this study, we evaluated ability two newly developed assays to directly detect nuc mecA genes in medium; specific Staphylococcus aureus, indicates methicillin resistance. We examined 263 samples taken at three hospitals suspected...
Smart Gene is a point-of-care (POC)-type automated molecular testing platform that can be performed with 1 min of hands-on-time. SARS-CoV-2 newly developed assay for the detection SARS-CoV-2. The analytical and clinical performance has not been evaluated.Nasopharyngeal anterior nasal samples were prospectively collected from subjects referred to local PCR center March 25 July 5, 2021. Two swabs simultaneously obtained reference real-time RT-PCR assay, results compared assay.Among total 1150...
TZT-1027 is a novel anticancer agent that inhibits microtubule polymerisation and manifests potent antitumour activity in preclinical models. We have examined the effect of on cell cycle progression as well this drug both vitro vivo. With use tsFT210 cells, which express temperature-sensitive mutant Cdc2, we found arrests mitosis, phase most sensitive to radiation. A clonogenic assay indeed revealed increased sensitivity H460 cells γ-radiation, with dose enhancement factor 1.2. Furthermore,...
ContextMany patients who have cancer consider opioid-induced constipation (OIC) to be a burdensome side effect of opioid treatment.ObjectivesTo evaluate patient-reported outcomes in Japanese with pain and OIC.MethodsThis prospective observational study evaluated OIC incidence for two weeks after they initiated strong therapy. Rome IV diagnostic criteria, physician's diagnosis, spontaneous bowel movements, Bowel Function Index score, patients' daily self-assessments were used. Changes from...
Abstract Background Constipation is a common side effect of opioid therapy. An observational study opioid-induced constipation (OIC) in Japanese patients with cancer (OIC-J) included 212 various tumor types. This post hoc analysis OIC-J evaluated subgroup gastrointestinal (GI) cancer. Methods Patients were aged ≥ 20 years, starting strong therapy, had an ECOG PS ≤ 2, and must have 3 bowel movements during the week before enrollment. OIC was for 2 weeks after initiation using Rome IV...