A5101955394- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Respiratory Support and Mechanisms
- Spine and Intervertebral Disc Pathology
- Shoulder Injury and Treatment
- Cancer-related Molecular Pathways
- Traumatic Brain Injury and Neurovascular Disturbances
- Bone fractures and treatments
- Cancer Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Cancer therapeutics and mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Elbow and Forearm Trauma Treatment
- Click Chemistry and Applications
- Gastric Cancer Management and Outcomes
- Intracranial Aneurysms: Treatment and Complications
- HER2/EGFR in Cancer Research
- Pelvic and Acetabular Injuries
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Pathology Studies
- Synthesis and Characterization of Heterocyclic Compounds
Saiseikai Utsunomiya hospital
2023
Suita Municipal Hospital
2014-2022
University of Miyazaki Hospital
2019
Keio University
1968-2018
Kindai University
2007-2015
Daiichi Sankyo (Germany)
2011-2015
Daiichi-Sankyo (Japan)
2011-2012
National Defense Medical College
2006-2011
Osaka City General Hospital
2001-2010
Yokohama City University Medical Center
2010
Purpose The primary goal of this open-label, multicenter, randomized phase III trial was to determine whether treatment with carboplatin plus the oral fluoropyrimidine derivative S-1 noninferior versus that paclitaxel regard overall survival (OS) in chemotherapy-naive patients advanced non–small-cell lung cancer (NSCLC). Patients and Methods A total 564 were randomly assigned receive either (area under curve, 5) on day 1 (40 mg/m 2 twice per day) days 14 or 6) (200 ) every 21 days. Results...
The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have variety of comorbidities, but little known about their impact on quality life. This study was designed to investigate comorbid factors that may contribute high CAT scores. An observational at Keio University and affiliated hospitals enrolled 336 67 non-COPD subjects. Health assessed by the CAT, St. Georges Respiratory Questionnaire (SGRQ), all components...
Tobacco is a major public health concern. A 12-week standard smoking cessation program available in Japan; however, it requires face-to-face clinic visits, which has been one of the key obstacles to completing program, leading low success rate. Telemedicine using internet-based video counseling instead regular visits could address this obstacle.This study aimed evaluate efficacy and feasibility an remote support compared with clinical visit among patients nicotine dependence.This was...
To determine the pharmacokinetics and safety of RAD001 (everolimus) in Japanese patients with advanced solid tumors. An open-label, non-randomized, dose-escalation Phase I study administered continuously once daily a 28-day cycle was performed. The had '3 + 3' design, three recruited to each successive cohorts treated at 2.5, 5.0 or 10.0 mg/day. were similar those previously determined Caucasians. drug profile consistent that mammalian target rapamycin inhibitor. No dose-limiting toxicities...
Chronic cigarette smoke (CS) exposure provokes variable changes in the lungs, and emphysema is an important feature of chronic obstructive pulmonary disease. The usefulness micro-computed tomography (CT) to assess different mouse models has been investigated, but few studies evaluated dynamic structural a CS-induced model. A novel micro-CT technique with respiratory cardiac gating resulted high-quality images that enable processing for further quantitative qualitative analyses. Adult female...
Identification of sensitized allergens for patients with respiratory allergy is an important step in disease care and environmental allergen control. The Japanese archipelago belongs to various climate categories due its length from north south which transverse the subarctic subtropical south, suggesting substantial regional differences dominant allergens. However, few studies have assessed prevalence sensitization allergens.We requested three major clinical testing laboratories provide us...
Objective: When dissimilar figures are presented to each eye individually, perception alternates spontaneously between monocular view. This phenomenon, known as binocular rivalry, has been used a powerful tool investigate conscious visual awareness. Of clinical relevance, Pettigrew and Miller ( Proc Biol Sci 1998; 265: 2141‐2148 ) found slow perceptual alternation rates in patients with bipolar I disorder (BD‐I). For better understanding of differences BD‐I II (BD‐II), we examined whether...
The design, synthesis, and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitors are described. In continuing our program aim to search for potent CDK4 inhibitors, the introduction a thiazole group at part has led marked enhancement chemical stability. Furthermore, by focusing on optimization C-4′ position ring C-6 thieno[2,3-d]pyrimidine moiety, compound 35 been identified with efficacy in xenograft model HCT116 cells. this paper,...
Abstract Background and objective Osteoporosis is an important systemic comorbidity of chronic obstructive pulmonary disease ( COPD ). However, neither its mechanisms nor risk factors have been fully elucidated. With regard to genetic factors, low‐density lipoprotein receptor‐related protein 5 LRP ) A 1330 V known be associated with osteoporosis in the general population, but influence this polymorphism unknown. The aim study was investigate potential ‐related bone loss fracture. Methods...
Smoking is a common risk factor for both chronic obstructive pulmonary disease (COPD) and osteoporosis. In patients with COPD, severe emphysema vertebral fracture; however, the effects of smoking or on bone health remain largely unknown. We report deterioration in mouse model induced by nose-only cigarette smoke (CS) exposure. Unexpectedly, short-term exposure 4-weeks decreased turnover increased volume mice. However, prolonged 20- 40-weeks reversed from suppression to promotion resorption....
BackgroundThe NEJ026 Phase 3 study demonstrated that erlotinib and bevacizumab (BE)-treated NSCLC patients with EGFR mutations had significantly better progression-free survival (PFS) than those treated alone (E). This included a prospective analysis of the relationship between mutational status in plasma circulating tumor DNA (ctDNA) efficacy TKI monotherapy or combination therapy. We describe these results herein.MethodsPlasma samples were collected from enrolled at start treatment (P0), 6...
Background: Triple combination therapy involving long-acting muscarinic antagonists β 2 agonists, and inhaled corticosteroids has recently become an option for maintenance treatment of COPD. Some add-on clinical trials have reported the benefits these combinations. However, process to step up triple varies individual cases. Methods: Keio University affiliated hospitals conducted observational COPD cohort study, recruiting patients diagnosed as having by pulmonary physicians those referred...
Although the age range of chronic obstructive pulmonary disease (COPD) patients is broad, few studies have focused on effects characteristics. Keio University and affiliated hospitals established an observational COPD cohort. Patients were assessed using high resolution computed tomography (CT) to quantify emphysema, health status assessment test (CAT) St. George's Respiratory Questionnaire (SGRQ), spirometry, echocardiogram, dual X-ray absorption bone, biomarkers comorbid diagnoses. We...