A5011353339- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Enzyme Catalysis and Immobilization
- Microfluidic and Bio-sensing Technologies
- Biosensors and Analytical Detection
- Quantum Dots Synthesis And Properties
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Advanced Biosensing Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Chemical Synthesis and Analysis
- Photonic and Optical Devices
- Protein purification and stability
- Advanced Proteomics Techniques and Applications
- Extraction and Separation Processes
- Electrowetting and Microfluidic Technologies
- Electrohydrodynamics and Fluid Dynamics
- Chalcogenide Semiconductor Thin Films
- Photonic Crystals and Applications
- Nanomaterials and Printing Technologies
- Photochemistry and Electron Transfer Studies
- Click Chemistry and Applications
- Nanopore and Nanochannel Transport Studies
- Monoclonal and Polyclonal Antibodies Research
- Semiconductor Lasers and Optical Devices
Gunma University
2023
Tokyo Medical University
2020-2021
National Institute of Technology, Tomakomai College
2021
Hokkaido University Hospital
2021
Kyushu University
2008-2020
Chitose Institute of Science and Technology
2020
National Institute of Advanced Industrial Science and Technology
2010-2019
Kyushu Institute of Technology
2002-2019
Hokkaido University
2012-2019
Sapporo City General Hospital
2019
Chalcopyrite-type CuInS2-based alloyed fluorescent nanocrystals (NCs), which contain no regulated heavy metal ions, were synthesized by heating an organometallic solution to demonstrate optical property tunability. Introduction of Zn into the CuInS2 system enhanced their photoluminescence (PL) intensity. The resultant particles 3−6 nm; they varied with experimental conditions and discrete colloidally stable. band-gap energy PL wavelength Zn-Cu-In-S (ZCIS) NCs content particle size. Their was...
A micro-reactor was utilized for continuous and controlled CdSe nanocrystal preparation. Effects of reaction conditions on optical properties the nanocrystals were investigated; in this current system, rapid exact temperature control beneficial controlling particle diameter reproducible preparation particles; additional effort made towards narrower particle-size distributions.
Ovarian cancer is one of the most aggressive female reproductive tract tumors. Paclitaxel (PTX) widely used for treatment ovarian cancer. However, cancers often acquire chemotherapeutic resistance to this agent. We investigated mechanism chemoresistance by analysis microRNAs using cell line KFr13 and its PTX-resistant derivative (KFr13Tx). found that miR-31 was downregulated in KFr13Tx cells, re-introduction miR31 re-sensitized them PTX both vitro vivo. bind 3'-UTR mRNA MET, decrease MET...
Enzymes are biocatalysts. They useful in environmentally friendly production processes and have high potential for industrial applications. However, because of problems with operational stability, cost, catalytic efficiency, many enzymatic limited The use cross-linked enzyme aggregates (CLEAs) has been introduced as an effective carrier-free immobilization method. This method is attractive it simple robust, unpurified enzymes can be used. Coimmobilization different achieved. CLEAs generally...
ZnS-coated CdSe composite particles have been continuously synthesized in a microfluidic reactor. By using this system, and ZnS coating can be produced sequence, the particle size layer thickness directly adjusted by residence time. It demonstrated that continuous synthesis microreactor was simple efficient way to prepare with different structures determine optimized experimental conditions.
Well-dispersed Y2O3:Eu nanocrystals, with a size less than 10 nm, and self-assembled nanodisks (see Figure) could be synthesized by simple organometallic route. Two strong emission peaks located between 610 630 2.6 % quantum yield, are achievable upon excitation at 330 nm. Excellent dispersibility, long lifetime, improved may allow nanocrystals to useful for biological labeling.
We have characterized an SH3-SH2-SH3 linker protein that is prominently expressed in lymphoid tissues. This has 58% sequence identity to Grb2. An identical called Grap been found hematopoietic cells. In Jurkat cells, T cell receptor activation leads the association of with phosphoproteins p36/38 and, a lesser degree, Shc. interaction mediated by SH2 domain, which similar binding specificity Grb2 domain. also associates via its SH3 domains Sos, Ras guanine nucleotide exchange factor; dynamin,...
An air-stable, low-toxicity, single-molecular source for ZnS is demonstrated to be an appropriate reagent synthesize highly luminescent ZnS-capped CdSe with a narrow size distribution. A photoluminescence quantum yield of above 50 % and peak full width at half maximum around 32 nm could obtained after synthesis using microreactor. The surface the nanocrystals can hydrophilic, while retaining high yield. Microscopic observation shows that accurate time control, which achieved by microreactor,...
We have developed a microfluidic system for polymerization of amino acid N-carboxyanhydride and compared the properties products with those obtained by batchwise under various experimental conditions. It was found that microreactor produced polymers narrower molecular weight distribution system. Also, mass polymer using simply governed flow (pumping) rate. These results indicated could be model synthesis highly controllable average distribution.
A stable interface between two insoluble currents in a microchannel reactor has been obtained by selecting the solvents and adjusting flow rate; titania particles with size of less than 10 nm could be prepared continuously on this interface; new method shows great advantage for control measurement particle sizes.
Bioremediation uses the degradation abilities of microorganisms and other organisms to remove harmful pollutants that pollute natural environment, helping return it a state is free substances. Organism-derived enzymes can degrade eliminate variety transform them into non-toxic forms; as such, they are expected be used in bioremediation. However, since proteins, low operational stability catalytic efficiency enzyme-based systems need improvement. Enzyme immobilization methods often overcome...
A novel and facile method for the preparation of an enzyme-immobilized microreactor has been developed in which enzymes are immobilized as enzyme-polymer membrane formed on inner wall microchannel by a cross-linking polymerization method; resulting shows excellent reaction performance stability against denaturating agents.
We used a microreactor for CdSe nanocrystal preparation and explored the effects of experimental conditions on properties products. The particle growth kinetics photoluminescence nanocrystals showed identical trends to previous reports, indicating efficiency current method analysis rapid synthesis as well industrial production nanocrystals.
Abstract The enzyme microreactor has considerable potential for use in biotechnological syntheses and analytical studies. Simplifying the procedure of immobilization a is attractive, it achievable by utilizing techniques taking advantage characteristics microfluidics. We previously developed facile inexpensive preparation method an enzyme‐immobilized microreactor. enzymes can be achieved formation enzyme‐polymeric membrane on inner wall microchannel through cross‐linking polymerization...
We developed a novel microreaction system for optical resolution of racemic amino acids. This device, which is based on continuous microfluidic system, consists an enzyme-immobilized microreactor and microextractor. Use the enzyme-microreactor, was prepared by membrane formation microchannel surface, enabled highly enantioselective reaction acid derivative. The microextractor provided laminar flow two immiscible solutions, selective extraction product. Using this integrated we could perform...