A5101668152- Dendrimers and Hyperbranched Polymers
- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Cell death mechanisms and regulation
- Animal Nutrition and Physiology
- Metal complexes synthesis and properties
- Viral-associated cancers and disorders
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Cancer-related gene regulation
- Click Chemistry and Applications
- Luminescence and Fluorescent Materials
- Analytical Chemistry and Chromatography
- Eicosanoids and Hypertension Pharmacology
- Acute Myeloid Leukemia Research
- Enzyme Production and Characterization
- RNA and protein synthesis mechanisms
- Cancer Research and Treatments
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
China Land Surveying and Planning Institute
2025
Shantou Central Hospital
2023-2024
Guangxi University of Chinese Medicine
2024
Zhejiang Sci-Tech University
2023
EY Technologies (United States)
2023
Unchained Labs (United States)
2023
Guangdong University of Technology
2010-2022
Shandong Academy of Agricultural Sciences
2007-2020
Guangxi Normal University
2018-2020
Yuhuangding Hospital
2010-2019
A new RNA-selective fluorescent dye shows excellent nucleolus RNA staining and imaging performance in live cells.
Given the critical role of urban green space (UGS) in fostering sustainable development, there is a growing focus on assessing levels and inequalities exposure. However, integration UGS with particularly context China’s unique national conditions, remains underexplored. This study evaluates adequacy equity provision 140 Chinese cities (with built-up areas exceeding 100 km2) using metrics such as percentage space, exposure, Gini coefficient. Additionally, investigates interplay between...
Heterozygous mutations in the CD95 (APO-1/Fas) receptor occur most individuals with autoimmune lymphoproliferative syndrome (ALPS) and dominantly interfere apoptosis by an unknown mechanism. We show that local or global alterations structure of cytoplasmic death domain from nine independent ALPS death-domain result a failure to bind FADD/MORT1 signaling protein. Despite heterozygosity for abnormal allele, lymphocytes patients showed markedly decreased FADD association loss caspase...
Triple-negative breast cancer (TNBC) is characterized by unique aggressive behavior and lack of targeted therapies. Among the various molecular subtypes cancer, it was observed that TNBCs express elevated levels sphingosine kinase 1 (SPHK1) compared to other tumor subtypes. High SPHK1 gene expression correlated with poor overall progression- free survival, as well response Doxorubicin-based treatment. Inhibition found attenuate ERK1/2 AKT signaling reduce growth TNBC cells in vitro a...
Nitrogen-doped porous activated carbon (PAC) has been fabricated <italic>via</italic> a facile heat-treatment and chemical activation of cocoon silk. The prepared PAC exhibits excellent ORR catalytic activity.
1. Although there is increasing evidence showing that boswellic acid might be a potential anticancer agent, the mechanisms involved in its action are unclear. 2. In present study, we showed acetyl-keto-beta-boswellic (AKBA) inhibited cellular growth several colon cancer cell lines. Cell cycle analysis by flow cytometry cells were arrested at G1 phase after AKBA treatment. 3. Further cyclin D1 and E, CDK 2 4 phosphorylated Rb decreased AKBA-treated while p21 expression was increased. 4. The...
Single site, functionalized, single stranded (ssDNA) dendri-poly(amidoamine) (PAMAM) di-dendrons have been synthesized by covalently conjugating complementary 32 base pair oligonucleotides to single-site, thiol functionalized dendri-PAMAM possessing neutral or anionic surface groups. Combining these (ss-DNA) PAMAM at appropriate assembly temperatures produced Watson−Crick paired (dsDNA) cores, surrounded four dendrons. These novel core−shell nanostructures represent a new class of precise...
Preparation of a novel c(RGDyK) targeted SN38 prodrug incorporating an indolequinone structure for bioreductively triggered drug release is described. This design yields that targets surface molecules on tumor cells (αvβ3 integrins) and releases under bioreductive conditions. There are three moieties in the design, namely therapeutic SN38, serving as releasing trigger, αvβ3 integrin targeting peptide c(RGDyK). Preliminary studies showed released presence enzyme (DT-diaphorase).
One partner of a fusion gene found in gastric cancer, CD44-SLC1A2 , may contribute to the tumor’s abnormal metabolism.
Abstract The function of Latexin (LXN) in inflammation has attracted attention. However, no data are available regarding its role colitis. We report that LXN is a suppressor deficiency leads to the severity colitis DSS-induced mice, and required for therapeutic effect retinoic acid on Using proteomics approach, we demonstrate interacts forms functional complex with HECTD1 (an E3 ubiquitin ligase) ribosomal protein subunit3 (Rps3). IκBα one substrates HECTD1. Ectopic expression accumulation...
Abstract BACKGROUND The pericarp of citrus in rutaceae is rich flavonoids that may possess diverse biological activities. Some have been used as natural bitterness inhibitors; however, many flavonoid analogues merit taste amelioration functions not reported with respect to utilization food industry. RESULTS effects 12 on the inhibition bitter naringin, quinine hydrochloride and stevioside were evaluated both by a sensory panel electronic tongue analysis. Among compounds evaluated,...