A5086077279- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Long-Term Effects of COVID-19
- Phagocytosis and Immune Regulation
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Neonatal Respiratory Health Research
- Mycobacterium research and diagnosis
- Tracheal and airway disorders
- Metastasis and carcinoma case studies
- Tumors and Oncological Cases
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Pulmonary Hypertension Research and Treatments
- Medical Imaging and Pathology Studies
- Cancer, Lipids, and Metabolism
- Hematological disorders and diagnostics
- Erythrocyte Function and Pathophysiology
- Pleural and Pulmonary Diseases
- Cancer Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- COVID-19 and Mental Health
- Infectious Diseases and Mycology
Nagano Municipal Hospital
2016-2025
Keio University
2004-2018
Fukuoka University
2011
University of Pittsburgh
2007-2010
Kameda Medical Center
2000
The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have variety of comorbidities, but little known about their impact on quality life. This study was designed to investigate comorbid factors that may contribute high CAT scores. An observational at Keio University and affiliated hospitals enrolled 336 67 non-COPD subjects. Health assessed by the CAT, St. Georges Respiratory Questionnaire (SGRQ), all components...
Background Multiple prolonged symptoms observed in patients who recovered from COVID-19 are defined as long COVID. Although diverse phenotypic combinations possible, they remain unclear. This study aimed to perform a cluster analysis of COVID Japan and clarify the association between its characteristics background factors quality life (QOL). Methods multicentre prospective cohort collected various QOL after January 2020 February 2021. included 935 aged ≥18 years with at 26 participating...
Besides lowering cholesterol, statins exert multiple effects, such as anti-inflammatory activity and improvement of endothelial cell function. We examined whether simvastatin (SS) protects against the development elastase-induced pulmonary emphysema in mice by using mean linear intercepts alveoli (Lm) a morphometric parameter emphysema. After injection intratracheal elastase on day 0, C57BL/6 were treated daily with SS (SS+ group) or PBS (SS- for 2 wk. A 21% decrease Lm 7 was observed SS+...
<b>Background:</b> Nicotine is responsible for smoking dependence and mainly metabolised by CYP2A6. Several types of genetic polymorphism <i>CYP2A6</i> have been reported, but their relation to habit chronic obstructive pulmonary disease (COPD) phenotypes has not fully clarified. <b>Methods:</b> 203 current or ex-smokers (lifelong cigarette consumption (CC) ≥10 pack years) with subclinical established COPD were clinically evaluated function tests a chest CT scan performed (smoker group). The...
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Purpose . This study aimed to examine whether plasma levels of cathepsin S or its inhibitor, cystatin C, may serve as biomarkers for COPD. Patients and Methods We measured anthropometrics performed pulmonary function tests chest CT scans on 94 patients with COPD 31 subjects productive cough but no airflow obstruction (“at risk”; AR). In these in 52 healthy nonsmokers (NS) 66 smokers (HS) we concentrations C using an ELISA. Data were analyzed simple logistic regression receiver operating...
The whole gene deletion CYP2A6*4 , the defect of main nicotine oxidase, contributes to limiting lifelong and daily cigarette consumption. However, effects on smoking habits CYP2A6*7 *9 two major functional polymorphisms common in Asian populations, have not been reported. present study examined relationship between *4 *7 with 200 Japanese smokers who visited Keio University Hospital (Tokyo, Japan). allele frequencies *1 (wild type), were 52, 17, 11 20%, respectively. When three considered...
Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro‐resolving mediator known to enhance functions, attenuates the damage of macrophages by CS extract (CSE) induced stress. RvE1 blocked p47phox translocation plasma membrane CSE in cell line, RAW264.7 cells, resulting suppression superoxide production. Furthermore, pretreatment cells with restored phagocytic activity and reduced death treatment CSE....
Efferocytosis is believed to be a key regulator for lung inflammation in chronic obstructive pulmonary disease. In this study we pharmacologically inhibited efferocytosis with annexin V and attempted determine its impact on the progression of emphysema mouse. We first demonstrated vitro vivo experiments using V, an inhibitor phosphatidylserine-mediated efferocytosis. then porcine pancreatic elastase (PPE)-treated mice. PPE-treated mice were instilled intranasally starting from day 8 until...
Introduction The rapid spread of COVID-19 posed a global burden. Substantial number people died the disease in acute phase infection. In addition, significant proportion patients have been reported to suffer from post-acute symptoms, sequelae COVID-19, which may negatively influence quality daily living and/or socioeconomic circumstances patients. However, no previous study has comprehensively and objectively assessed life by using existing international scales. Further, evidence...
Chronic eosinophilic pneumonia (CEP) is characterized by chronic or recurrent pulmonary infiltrates with eosinophils, but the precise mechanism of eosinophil accumulation has not been fully elucidated. Eotaxin one CC chemokines that selectively recruits eosinophils and contributes to pathogenesis allergic airway diseases including asthma, its roles in CEP have The authors measured concentrations eotaxin other chemokines, monocyte chemoattractant protein-1 (MCP-1), regulated on activation,...
Invasive mucinous adenocarcinoma (IMA), formerly referred to as bronchioloalveolar carcinoma, is a rare variant form of invasive and radiologically characterized by dense pneumonic consolidation, ground-glass opacity nodules. By contrast, large, thin-walled cysts are rare. We herein report the case 75-year-old man with IMA presenting irregularly shaped cystic lesion. The histological diagnosis was based on specimens obtained during bronchoscopy. patient underwent lobectomy followed...
Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular (VE-) cells. Soluble (s) cadherin released from the cell surface effects of proteases including matrix metalloproteinases (MMPs).The aim this study was to examine associations sE-/sVE-cadherin levels in plasma development COPD.Plasma sE-/VE-cadherin were measured an enzyme-linked immunosorbent assay 115 patients...
Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema non-emphysema types. We aimed to identify biomarkers related the smoking-sensitivity phenotypes of COPD. Among 240 suggestive COPD, we studied on four groups defined by % forced expiratory volume one second (FEV1) computed tomography-based emphysema. Plasma concentrations 33 inflammatory markers were measured as well Non-smokers using multiplex...
Osimertinib is widely used for the treatment of advanced lung cancers harboring epidermal growth factor receptor (EGFR) mutations. Because its inhibitory activity on human 2 pathway, osimertinib-induced cardiotoxicity concerning. Large-scale international clinical studies revealed a subclinical decline in left ventricular ejection fraction (LVEF) with osimertinib, which allowed continuation drug. Only few have reported symptomatic heart failure reduced (HFrEF) and impact real-world settings...
Giant cell carcinoma, a rare variant of nonsmall lung carcinoma (NSCLC), is characterized by aggressive progression and poor response to conventional chemotherapy. This report the first describe patient with NSCLC giant features who was successfully treated pembrolizumab, an antibody targeting programmed death-1 (PD-1). A 69-year-old woman diagnosed multiple brain metastases. Histological evaluation biopsy specimens revealed proliferation pleomorphic tumor cells cohesiveness, findings...
Background and objective: Cathepsin S is involved in the pathogenesis of COPD murine models overexpressing interferon (IFN)‐γ IL‐13. It widely accepted that genetic factors partly influence susceptibility to COPD; however, association polymorphisms cathepsin gene with has not been reported previously. In this study, functional 5′‐flanking region human were identified their phenotypes was investigated. Methods: Genetic detected by single strand conformation polymorphism analysis direct...