Kazuma Yagi
A5070715121- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Infectious Diseases and Mycology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Infectious Diseases and Tuberculosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diabetes and associated disorders
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Influenza Virus Research Studies
- Tracheal and airway disorders
- interferon and immune responses
- Gut microbiota and health
- Dysphagia Assessment and Management
- Asthma and respiratory diseases
- COVID-19 and Mental Health
Keio University
2016-2025
keiyu Hospital
2020-2025
University of Michigan
2021-2025
Kansai University
2023-2024
Tokyo Medical Center
2019-2024
Michigan United
2022-2024
National Hospital Organization
2019-2021
Pulmonary Associates
2015-2021
Osaka University
2011
BackgroundTo develop an effective vaccine against a novel viral pathogen, it is important to understand the longitudinal antibody responses its first infection. Here we performed study of SARS-CoV-2 in symptomatic patients.MethodsSequential blood samples were collected from 39 individuals at various timepoints between 0 and 154 days after onset. IgG or IgM titers receptor binding domain (RBD) S protein, ectodomain N protein determined by using ELISA. Neutralizing measured plaque reduction...
Significance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are of concern, with the P.1 dominating in Brazil. Brazil is now seeing a record number deaths. Here, we report that pathogenicity hamsters variant similar to nonvariant SARS-CoV-2. However, it has an expanded host range as shown by its replication mice. Prior infection SARS-CoV-2 strains efficiently prevented lower tract upon reinfection. Convalescent sera from patients infected nonvariants or messenger RNA...
In multidrug regimens, including an intravenous aminoglycoside (e.g. amikacin [AMK]) is recommended for difficult-to-treat non-tuberculous mycobacterial (NTM) lung diseases. We aimed to evaluate the efficacy, safety, and feasibility of inhaled AMK therapy in patients with NTM diseases a retrospective chart review. The study population consisted who received combination therapy, at Keio University Hospital (Tokyo, Japan), from January 2014 through May 2016. A total 26 cases, consisting 23...
Early-life respiratory virus infections have been correlated with enhanced development of childhood asthma. In particular, significant numbers syncytial (RSV)-hospitalized infants go on to develop lung disease. It has suggested that early-life viral may lead altered or repair negatively impacts function later in life. Our data demonstrate RSV infection modifies structure, leading decreased function. At 5 wk postneonatal infection, defects are observed baseline pulmonary test (PFT) parameters...
Increasing evidence suggests that mesenchymal stem cells (MSCs) play anti-inflammatory roles during innate immune responses. However, little is known about the effect of MSCs or their secretions on ligand response Toll-like receptor (TLR) 7 and TLR8, receptors recognize viral single-stranded RNA (ssRNA). Macrophages a critical role in to ssRNA virus infection; therefore, we investigated MSC-conditioned medium cytokine expression macrophages following stimulation with TLR7/8 ligands. After...
Mycobacterium avium complex (MAC) lung diseases generally cause chronic disease in immunocompetent hosts. Although a few studies have examined health-related quality of life (HRQL) patients with MAC disease, there been no large studies. This study aimed to evaluate HRQL and its correlation clinical outcomes disease.A cross-sectional was conducted at Keio University Hospital investigate the factors associated pulmonary nontuberculous mycobacterial diseases. were diagnosed according 2007...
In the Berlin definition, acute respiratory distress syndrome (ARDS) is stratified into three stages according to oxygenation severity at onset. The relevance between ARDS and prognosis varies among published reports has not been verified, especially in Asian patients. this study, we examined associations definition criteria clinical parameters, including high-resolution computed tomography (HRCT) scores of fibroproliferative changes lungs. One hundred fifty-three patients (45 females; mean...
Nontuberculous mycobacteria (NTM) are environmental that can cause a chronic progressive lung disease. Although epidemiological data indicate potential genetic predisposition, its nature remains unclear.We aimed to identify host susceptibility loci for Mycobacterium avium complex (MAC), the most common NTM pathogen.This genome-wide association study (GWAS) was conducted in Japanese patients with pulmonary MAC and healthy controls, followed by genotyping of candidate single-nucleotide...
In the present studies, assessment of how viral exacerbation asthmatic responses with and without pulmonary steroid treatment alters microbiome in conjunction immune presents striking data. The overall findings identify that although allergic animals diminished severity respiratory syncytial virus (RSV)-induced airway function mucus hypersecretion, there were local increases IL-17 expression. Analysis lung gut suggested are differences RSV further altered by fluticasone (FLUT) treatment....
A double-blind, placebo-controlled, parallel-group, multicentre study was conducted to evaluate the efficacy of pentoxifylline (Trental) in patients with multi-infarct dementia (MID) according DSM-III-R criteria. Men and women aged 45 years or older, a Hachinski Ischemia Scale score > = 7 Mini Mental State Examination (MMSE) 10-25 at entry, computed tomographic evidence vascular disease were enrolled. total 289 randomised receive either oral 400 mg t.i.d. placebo for 9 months, assessed every...
Macrolides are used to treat various inflammatory diseases owing their immunomodulatory properties; however, little is known about precise mechanism of action. In this study, we investigated the functional significance expansion myeloid-derived suppressor cell (MDSC)-like CD11b+Gr-1+ cells in response macrolide antibiotic clarithromycin (CAM) mouse models shock and post-influenza pneumococcal pneumonia as well humans. Intraperitoneal administration CAM markedly expanded splenic lung...
Severe respiratory syncytial virus (RSV) infection during infancy is associated with a 2 to 4-fold increased risk for the development of wheezing and asthma. Recent studies have implicated microbiome changes, either within lung or gut, early life can also affect pulmonary disease. Our demonstrate long-term gastrointestinal changes following (EL) RSV infection. To determine respective roles ELRSV gut microbiome, we performed germ-free neonatal colonization using from an uninfected animal...
Various prolonged systemic symptoms, forming the long coronavirus disease (COVID), have been observed in patients who recovered from acute phase of COVID-19. Although previous studies reported that COVID-19 impacts health-related quality life (HRQoL), associations COVID symptoms and clinical characteristics with HRQoL remain unclear. This study aimed to clarify these using nationwide Japanese epidemiological data. A prospective cohort was conducted on between January 2020 February 2021 at 26...
Introduction Glycemic control following pancreatectomy presents challenges, especially in patients with diabetes due to a lack of endogenous insulin, however, optimal management remains unclear. This study evaluated the efficacy and safety continuous intravenous insulin infusion protocol employed at our institution, comparison conventional glycemic pancreatectomy. Materials methods Sixty-one preoperative glycosylated hemoglobin (HbA1c) 6.5% or higher, on medications, who underwent total were...
In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (MACLD) patients in this context. This study aimed to evaluate HRQL and investigate the impact PA MACLD patients. cross-sectional was conducted using Registry Prospective Cohort Study including The 36-item Short-Form health survey (SF-36) St. George’s Respiratory Questionnaire (SGRQ)...