A5046968982- Diabetes Management and Research
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diet and metabolism studies
- Advanced Glycation End Products research
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Cerebrovascular and Carotid Artery Diseases
- Endoplasmic Reticulum Stress and Disease
- Diabetes Management and Education
- Cardiovascular Function and Risk Factors
- Diabetic Foot Ulcer Assessment and Management
- Adipose Tissue and Metabolism
- Blood Pressure and Hypertension Studies
- Retinal Diseases and Treatments
- Chronic Kidney Disease and Diabetes
- Muscle metabolism and nutrition
- Cardiovascular Disease and Adiposity
Tokushima University
2016-2025
Tokushima University Hospital
2010-2021
Takara (Japan)
2019
Osaka University
2003-2015
Fukushima Medical University
2015
Kanazawa Medical University
2005
Kanazawa University
2005
Kwansei Gakuin University
1998-2003
Sumitomo Dainippon Pharma (Japan)
2003
University of Toronto
1997-2000
It has been shown that oxidative stress and activation of the c-Jun N-terminal kinase (JNK) pathway induce nucleocytoplasmic translocation pancreatic transcription factor PDX-1, which leads to β-cell dysfunction. In this study, we have forkhead Foxo1/FKHR plays a role as mediator between JNK PDX-1. Under conditions, Foxo1 changed its intracellular localization from cytoplasm nucleus in line HIT-T15. The overexpression also induced nuclear Foxo1, but contrast, suppression reduced...
The c-Jun N-terminal kinase (JNK) pathway is known to be activated under diabetic conditions and possibly involved in the progression of insulin resistance. In this study, we examined effects modulation JNK liver on resistance glucose tolerance. Overexpression dominant-negative type obese mice dramatically improved markedly decreased blood levels. Conversely, expression wild normal sensitivity. phosphorylation state crucial molecules for signaling was altered upon modification pathway....
To determine the role of endoplasmic reticulum (ER) in diabetes, Akita mice, a mouse model type 2 were mated with either heterozygous knockout mice or two types transgenic 150-kDa oxygen-regulated protein (ORP150), molecular chaperone located ER. Systemic expression ORP150 improves insulin intolerance, whereas exclusive overexpression pancreatic beta-cells did not change their glucose tolerance. Both an tolerance test and hyperinsulinemic-euglycemic clamp revealed that enhanced uptake,...
To determine the impact of blood glucose profile, involving fluctuation and excursion levels, on glycated proteins, we evaluated association among daily profile glucose, albumin (GA) HbA1c levels in patients with type 1 diabetes (n = 93) 2 75). GA were strongly correlated (r 0.85, P<0.0001) 0.61, P<0.0001), respectively. similar between diabetes, while significantly higher diabetes. Thus ratio to was than that (3.32 0.36 vs. 2.89 0.44, p<0.001). The degrees maximum mean Stepwise multivariate...
Diabetes is the most prevalent and serious metabolic disease, number of diabetic patients worldwide increasing. The reduction insulin biosynthesis in pancreatic β-cells closely associated with onset progression diabetes, thus it important to search for ways induce insulin-producing cells non−β-cells. In this study, we showed that a modified form duodenal homeobox factor 1 (PDX-1) carrying VP16 transcriptional activation domain (PDX-1/VP16) markedly increases induces various pancreas-related...
Fibroblast growth factor (FGF) 23 produced by bone is a hormone that decreases serum phosphate (Pi). Reflecting its central role in Pi control, FGF23 tightly regulated alterations. levels are the transcriptional event and posttranslational cleavage into inactive fragments before secretion. For latter, O-glycosylation of GALNT3 gene product prevents cleavage, leading to an increase FGF23. However, molecular basis sensing regulation remains elusive. In this study, we showed high diet enhanced...
A new and highly efficient method for generating mutant pigs by electroporating the CRISPR/Cas9 system into zygotes.
Advanced glycation end-products (AGEs), which are a major cause of diabetic vascular complications, accumulate in various tissues under chronic hyperglycemic conditions, as well with aging patients diabetes. The loss muscle mass and strength, so-called sarcopenia dynapenia, has recently been recognized complication. However, the influence accumulated AGEs on strength remains unclear. present study aimed to evaluate association dynapenia type 2 diabetes.We recruited 166 diabetes aged ≥30...
To examine carotid intima-media thickness (IMT), predictors of its progression, and relationship with incident coronary heart disease (CHD) in type 2 diabetic Japanese patients.Carotid IMT 287 subjects diabetes (mean age 61.6 years) without CHD or cerebrovascular was examined at baseline after a mean follow-up 3.1 years.The annual progression (means +/- SEM) 0.04+/-0.004 mm/year. Stepwise multivariate analysis demonstrated that independent risk factors for progress were the initial...
OBJECTIVE—The binding of advanced glycation end products (AGEs) to their receptor (RAGE) plays an important role in the development diabetic vascular complications. In present study, we examined circulating endogenous secretory RAGE (esRAGE) levels subjects with type 1 diabetes and explored possible association between esRAGE severity RESEARCH DESIGN AND METHODS—Circulating serum were 67 Japanese patients (22 men 45 women, age 24.0 ± 4.4 years [means SD]) 23 age-matched healthy nondiabetic...
To study the effects of aging and gender, circadian profiles heart rate variability were evaluated for 105 healthy volunteers by frequency domain analysis a Holter electrocardiogram record. The low-frequency (LF) component representing cardiac beta-adrenergic function showed high values 0800-1200 period in male subjects 1200-2400 female subjects. high-frequency (HF) parasympathetic peak 0000-0600 both independent age. Male significantly higher %LF [LF/(LF + HF) x 100] than LF consistently...
A paired homeodomain transcription factor, PAX6, is a well-known regulator of eye development, and its heterozygous mutations in humans cause congenital anomalies such as aniridia. Because it was recently shown that PAX6 also plays an indispensable role islet cell gene mutation may lead to defect the endocrine pancreas. Whereas islet-cell factors IPF1/IDX-1/STF-1/PDX-1 NEUROD1/BETA2 serve genetic diabetes or glucose intolerance, we investigated possibility being factor common aniridia...
MafA, a recently isolated pancreatic beta-cell-specific transcription factor, is potent activator of insulin gene transcription. In this study, we show that MafA overexpression, together with PDX-1 (pancreatic and duodenal homeobox factor-1) NeuroD, markedly increases expression in the liver. Consequently, substantial amounts protein were induced by such combination. Furthermore, streptozotocin-induced diabetic mice, overexpression liver, dramatically ameliorated glucose tolerance, while...
To evaluate whether low-grade inflammation contributes to early-stage advanced carotid atherosclerosis in young subjects with type 1 diabetes.The mean and maximum (max) intima-media thicknesses (IMT) of the artery were assessed using ultrasound B-mode imaging 55 patients diabetes (22 men 33 women, aged 22.1 +/- 3.6 years (+/- SD), duration 14.2 5.7 years) 75 age-matched healthy nondiabetic (28 47 women). High-sensitive C-reactive protein (hs-CRP) levels measured a latex-enhanced...
Reactive oxygen species (ROS) are induced under diabetic conditions and likely associated with the development of type 2 diabetes. It is also known that ROS production facilitated in presence copper ion through Fenton reaction. The aim this study was to examine involvement pathogenesis diabetes evaluate potential usefulness a chelating agent for treatment First, both serum levels C57BL/KsJ-db/db mice were significantly higher compared those nondiabetic mice. Second, we treated db/db...
OBJECTIVE Islet β-cells loose their ability to synthesize insulin under diabetic conditions, which is at least partially due the decreased activity of transcription factors such as MafA. Although an in vitro study showed that reactive oxygen species (ROS) decrease MafA expression, underlying mechanism still remains unclear. In this study, we examined effects c-Jun, known be upregulated by ROS, on expression conditions. RESEARCH DESIGN AND METHODS To examine protein levels and performed...
To compare efficacy and safety of new insulin glargine 300 U/ml (Gla-300) with that 100 (Gla-100) in Japanese adults type 1 diabetes.
Background Experimental studies have suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors provide cardiovascular protective effects. We performed a randomized study to evaluate the effects of sitagliptin added on conventional therapy compared with alone (diet, exercise, and/or drugs, except for incretin-related agents) intima-media thickness (IMT) carotid artery, surrogate marker evaluation atherosclerotic disease, in people type 2 diabetes mellitus (T2DM). Methods and Findings used...