A5033376925- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Endoplasmic Reticulum Stress and Disease
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Cardiovascular Health and Disease Prevention
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- FOXO transcription factor regulation
- Pancreatitis Pathology and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adrenal Hormones and Disorders
- Vitamin D Research Studies
- Autophagy in Disease and Therapy
- Pluripotent Stem Cells Research
- Adipokines, Inflammation, and Metabolic Diseases
- Natural Antidiabetic Agents Studies
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Chromatin Remodeling and Cancer
- Chemokine receptors and signaling
Osaka University
2015-2025
Osaka University Hospital
2022-2025
Kawasaki Hospital
2021-2023
Suita Municipal Hospital
2018
Joslin Diabetes Center
2010-2017
Harvard University
2007-2014
Brigham and Women's Hospital
2011-2014
Harvard University Press
2010
University of Bergen
2010
Kanazawa Medical University
2005
The transcriptional coactivator PPARgamma 1alpha (PGC-1alpha) is a strong activator of mitochondrial biogenesis and oxidative metabolism. While expression PGC-1alpha many its target genes are decreased in the skeletal muscle patients with type 2 diabetes, no causal relationship between abnormal glucose metabolism has been established. To address this question, we generated muscle-specific knockout mice (MKOs), which developed significantly impaired tolerance but showed normal peripheral...
It has been shown that oxidative stress and activation of the c-Jun N-terminal kinase (JNK) pathway induce nucleocytoplasmic translocation pancreatic transcription factor PDX-1, which leads to β-cell dysfunction. In this study, we have forkhead Foxo1/FKHR plays a role as mediator between JNK PDX-1. Under conditions, Foxo1 changed its intracellular localization from cytoplasm nucleus in line HIT-T15. The overexpression also induced nuclear Foxo1, but contrast, suppression reduced...
The c-Jun N-terminal kinase (JNK) pathway is known to be activated under diabetic conditions and possibly involved in the progression of insulin resistance. In this study, we examined effects modulation JNK liver on resistance glucose tolerance. Overexpression dominant-negative type obese mice dramatically improved markedly decreased blood levels. Conversely, expression wild normal sensitivity. phosphorylation state crucial molecules for signaling was altered upon modification pathway....
Oxidative stress is induced in pancreatic β-cells under diabetic conditions and causes β-cell dysfunction. Antioxidant treatment of animals leads to recovery insulin biosynthesis increases the expression its controlling transcription factor, duodenal homeobox-1 (PDX-1), β-cells. Here, we show that PDX-1 translocated from nuclei cytoplasm response oxidative stress. When was charged upon β-cell-derived HIT-T15 cells, both endogenous exogenously introduced green fluorescent protein-tagged moved...
Background. Differential diagnosis of angiosarcoma, predominantly showing a non- or poorly vasoformative proliferation from other types sarcomas, differentiated carcinomas, and amelanotic melanoma, is often problematic. Methods. The use antibodies directed against Factor VIII-related antigen (FVIIIRA), Ulex europaeus lectin type 1 (UEA-1), CD31, vascular endothelial growth factor (VEGF) in the angiosarcoma was examined 98 cases autopsy-proven diagnosed during 1974-1990 survey 178 Japanese...
Aberrations in epigenetic processes, such as histone methylation, can cause cancer. Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) demethylate tri- and dimethylated lysine 4 H3, which are marks for transcriptionally active chromatin, whereas the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation. Previous studies suggested that inhibition of RBP2 contributed to suppression by retinoblastoma (pRB). Here, we show genetic ablation Rbp2...
Integrative organ crosstalk regulates key aspects of energy homeostasis, and its dysregulation may underlie metabolic disorders such as obesity diabetes. To test the hypothesis that between liver pancreatic islets modulates β cell growth in response to insulin resistance, we used liver-specific receptor knockout (LIRKO) mouse, a unique model exhibits dramatic islet hyperplasia. Using complementary vivo parabiosis transplantation assays, well vitro culture approaches, demonstrate humoral,...
Insufficient insulin secretion and reduced pancreatic beta cell mass are hallmarks of type 2 diabetes (T2DM). Here, we confirm that a previously identified polymorphism (rs2295490/Q84R) in exon the pseudokinase-encoding gene tribbles 3 (TRB3) is associated with an increased risk for T2DM populations people mixed European descent. Carriers 84R allele had substantially plasma levels C-peptide, product proinsulin processing to insulin, suggesting role TRB3 function. Overexpression mouse cells,...
Glucagon-like peptide-1 (GLP-1) protects β-cells against apoptosis, increases their glucose competence, and induces proliferation. We previously demonstrated that the anti-apoptotic effect was mediated by an increase in insulin-like growth factor-1 receptor (IGF-1R) expression signaling, which dependent on autocrine secretion of factor 2 (IGF-2). Here, we further investigated how GLP-1 IGF-1R whether IGF-2/IGF-1R loop is also involved mediating GLP-1-increase competence show up-regulated a...
Abstract Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis only transcriptional activator present islet β-cells. Here we show that ectopic expression sufficient to induce a small amount endogenous insulin variety non-β-cell lines. mRNA protein was induced much higher level when provided with two other key activators, pancreatic duodenal homeobox (PDX-1) BETA2....