A5026189830- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Chromosomal and Genetic Variations
- Pluripotent Stem Cells Research
- Endoplasmic Reticulum Stress and Disease
- Voice and Speech Disorders
- Cancer-related gene regulation
- Chromatin Remodeling and Cancer
- Dysphagia Assessment and Management
- Plant Virus Research Studies
- RNA regulation and disease
- Hearing, Cochlea, Tinnitus, Genetics
- Genetics, Aging, and Longevity in Model Organisms
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Tracheal and airway disorders
- Fungal and yeast genetics research
- Pancreatic function and diabetes
- 3D Printing in Biomedical Research
- Thyroid and Parathyroid Surgery
Center for Life Sciences
2016-2025
Tsinghua University
2016-2025
Hunan Agricultural University
2025
Peking University
2003-2024
Jiangxi Provincial Cancer Hospital
2024
King Center
2020
Dana-Farber Cancer Institute
2006-2015
Harvard University
2006-2015
Harvard Stem Cell Institute
2006-2015
Harvard University Press
2015
All eukaryotic cells respond to the accumulation of unfolded proteins in endoplasmic reticulum (ER) by signaling an adaptive pathway termed protein response (UPR). In yeast, a type-I ER transmembrane kinase, Ire1p, is proximal sensor lumen that initiates unconventional splicing reaction on HAC1 mRNA. Hac1p transcription factor required for induction UPR genes. higher cells, also induces site-2 protease (S2P)-mediated cleavage ER-localized ATF6 generate N-terminal fragment activates To...
Polycomb-repressive complex 2 (PRC2) promotes tissue-specific differentiation by depositing trimethylated histone H3 Lys 27 (H3K27me3) epigenetic marks to silence ectopic gene expression programs. Here, we show that EZH2, the catalytic subunit of PRC2, is required for cardiac morphogenesis. Both in vitro and fetal hearts, EZH2 interacted with transcription factor GATA4 directly methylated it at 299. PRC2 methylation attenuated its transcriptional activity reducing interaction acetylation...
Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved relatively stable during lineage differentiation. In an effort unravel basic principle underlying folding, here we focus on itself report a fundamental role for L1 (LINE1 or LINE-1) B1/Alu retrotransposons, most abundant subclasses repetitive sequences, in chromatin compartmentalization. We find that homotypic clustering demarcates grossly exclusive domains, characterizes predicts Hi-C...
Repetitive elements are abundantly distributed in mammalian genomes. Here, we reveal a striking association between repeat subtypes and gene function. SINE, L1, low-complexity repeats demarcate distinct functional categories of genes may dictate the time level expression by providing binding sites for different regulatory proteins. Importantly, imaging sequencing analysis show that L1 sequester large set with specialized functions nucleolus- lamina-associated inactive domains depleted SINE...
The unfolded protein response (UPR) is an adaptive signaling pathway utilized to sense and alleviate the stress of folding in endoplasmic reticulum (ER). In mammals, UPR mediated through three proximal sensors PERK/PEK, IRE1, ATF6. PERK/PEK a kinase that phosphorylates alpha subunit eukaryotic translation initiation factor 2 inhibit synthesis. Activation IRE1 induces splicing XBP1 mRNA produce potent transcription factor. ATF6 transmembrane activated by cleavage upon ER stress. We show...
Aberrations in epigenetic processes, such as histone methylation, can cause cancer. Retinoblastoma binding protein 2 (RBP2; also called JARID1A or KDM5A) demethylate tri- and dimethylated lysine 4 H3, which are marks for transcriptionally active chromatin, whereas the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor promotes H3K4 methylation. Previous studies suggested that inhibition of RBP2 contributed to suppression by retinoblastoma (pRB). Here, we show genetic ablation Rbp2...