A5063742204- Gas Sensing Nanomaterials and Sensors
- Pluripotent Stem Cells Research
- Advanced Chemical Sensor Technologies
- Genomics and Chromatin Dynamics
- Analytical Chemistry and Sensors
- Congenital heart defects research
- 3D Printing in Biomedical Research
- CRISPR and Genetic Engineering
- Cardiac electrophysiology and arrhythmias
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Reproductive Biology and Fertility
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Neuroscience and Neural Engineering
- Spaceflight effects on biology
- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
- Face and Expression Recognition
- Text and Document Classification Technologies
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Electrochemical sensors and biosensors
Lanzhou University
2022-2025
Tsinghua University
2012-2024
Boston Children's Hospital
2023-2024
Boston Children's Museum
2024
Center for Life Sciences
2019-2021
Xi'an Jiaotong University
2020
Minzu University of China
2011
Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved relatively stable during lineage differentiation. In an effort unravel basic principle underlying folding, here we focus on itself report a fundamental role for L1 (LINE1 or LINE-1) B1/Alu retrotransposons, most abundant subclasses repetitive sequences, in chromatin compartmentalization. We find that homotypic clustering demarcates grossly exclusive domains, characterizes predicts Hi-C...
Timing and trigger of cell polarization During mammalian embryo development, the first fate decision separates progenitors trophectoderm (destined to form placenta) from inner mass (which forms all tissues embryonic yolk sac). A key event for this lineage segregation is establishment apicobasal polarity. This set occur at a fixed developmental stage. The factors that polarity as well its temporal regulation have remained unknown. Zhu et al. show in mouse embryos three molecular...
Background: Cardiac chamber-selective transcriptional programs underpin the structural and functional differences between atrial ventricular cardiomyocytes (aCMs vCMs). The mechanisms responsible for these remain largely undefined. Methods: We nominated candidate enhancers (CSEs) by determining genome-wide occupancy of 7 key cardiac transcription factors (GATA4, MEF2A, MEF2C, NKX2-5, SRF, TBX5, TEAD1) coactivator P300 in atria ventricles. Candidate were tested using an adeno-associated...
Oxygen vacancies (V
Abstract The mouse and human embryo gradually loses totipotency before diversifying into the inner cell mass (ICM, future organism) trophectoderm (TE, placenta). transcription factors TFAP2C TEAD4 with activated RHOA accelerate polarization. Here we show that these also loss of totipotency. paradoxically promote inhibit Hippo signaling lineage diversification: they drive expression multiple regulators while promoting apical domain formation, which inactivates Hippo. Each factor activates TE...
BACKGROUND: Calmodulinopathies are rare inherited arrhythmia syndromes caused by dominant heterozygous variants in CALM1 , CALM2 or CALM3 which each encode the identical CaM (calmodulin) protein. We hypothesized that antisense oligonucleotide (ASO)–mediated depletion of an affected calmodulin gene would ameliorate disease manifestations, whereas other 2 genes preserve level and function. METHODS: tested this hypothesis using human induced pluripotent stem cell–derived cardiomyocyte mouse...
On the ground that acetone is a common flammable and physiologically toxic gas, it an important task to detect sensitively. Cobalt ferrite exhibits promising characteristics for enhancing gas sensitivity due their variable polyvalent cations controllable components, yet lucubrate on sensing capabilities still inadequate. In this study, series of cobalt CoxFe(3–x)O4 (x = 0.47–0.87) nanoparticles were synthesized sensitive detection factors impacting performance explored. The response...
Deep neural networks (DNNs) typically employ an end-to-end (E2E) training paradigm which presents several challenges, including high GPU memory consumption, inefficiency, and difficulties in model parallelization during training. Recent research has sought to address these issues, with one promising approach being local learning. This method involves partitioning the backbone network into gradient-isolated modules manually designing auxiliary train modules. Existing methods often neglect...
Stem cell-based embryo models by cultured pluripotent and extra-embryonic lineage stem cells are novel platforms to model early postimplantation development. We showed that induced (iPSCs) could form ITS (iPSCs trophectoderm cells) ITX (iPSCs, cells, XEN embryos, resembling the gastrula developed in vivo. To facilitate efficient unbiased analysis of model, we set up a machine learning workflow extract multi-dimensional features perform quantification embryos using 3D images collected from...
Transition metal oxide semiconductors have great potential for use in H
Abstract Coordination of cell division and fate is crucial for the successful development mammalian early embryos. Aurora kinases are evolutionarily conserved serine/threonine key regulators mitosis. kinase B (AurkB) ubiquitously expressed while C (AurkC) specifically in gametes preimplantation We found that increasing AurkC level one blastomere 2-cell embryo accelerated decreasing slowed down Changing AurkB had opposite effect. The domains were responsible their different ability to...