A5036757264- Glaucoma and retinal disorders
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Neurological Disorders and Treatments
- Ocular Infections and Treatments
- Pain Mechanisms and Treatments
- Corneal Surgery and Treatments
- Nitric Oxide and Endothelin Effects
- Hypothalamic control of reproductive hormones
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ocular Diseases and Behçet’s Syndrome
- Retinoids in leukemia and cellular processes
- Biochemical effects in animals
- Ophthalmology and Visual Impairment Studies
- Drug-Induced Ocular Toxicity
- Neuroscience and Neuropharmacology Research
- Optical Imaging and Spectroscopy Techniques
- Cerebral Venous Sinus Thrombosis
- Neurobiology and Insect Physiology Research
Tokushima Breast Care Clinic
2011-2023
Katsushika Medical Center
2015
Jikei University School of Medicine
2015
Osaka National Hospital
2015
Senju Pharmaceutical (United States)
2015
Osaka Kaisei Hospital
1995-2014
Osaka Hospital
2004-2009
Koujin Hospital
2003
Osaka University
1981-1995
Hyogo Prefectural Institute of Environmental Sciences
1994
Abstract Purpose To investigate the intra‐ocular pressure ( IOP )‐lowering effects and safety of 0.4% ripasudil (K‐115), a Rho kinase inhibitor, twice daily for 52 weeks, in patients with open‐angle glaucoma or ocular hypertension OHT ). Methods In this multicentre, prospective, open‐label study, 388 primary glaucoma, exfoliation were enrolled 354 them subdivided into four cohorts (monotherapy, 173; additive therapy to prostaglandin analogs, 62; β ‐blockers, 60; fixed combination drugs, 59)....
We conducted a series of phase 1 clinical trials to elucidate the efficacy and safety selective Rho kinase inhibitor K-115 as candidate drug for treatment glaucoma. report intraocular pressure (IOP)-lowering effects based on our results.To study IOP-lowering topical administration inhibitor, K-115, in healthy male adult volunteers.Randomized, placebo-controlled, double-masked, group comparison trial.In initial single-instillation trial, 50 volunteers were subdivided into groups treated with...
Ripasudil hydrochloride hydrate (K-115), a novel rho kinase inhibitor, provides statistically significant intraocular pressure (IOP)-lowering effects and has tolerable safety profile. However, no studies have evaluated ripasudil combined with β-blockers prostaglandin analogues.To evaluate the additive IOP-lowering of ripasudil, 0.4%, timolol, 0.5%, or latanoprost, 0.005%, in patients primary open-angle glaucoma ocular hypertension.We conducted 2, multicenter, randomized, double-masked,...
Abstract Purpose To investigate the intra‐ocular pressure ( IOP )‐lowering effects of a selective Rho kinase inhibitor, ripasudil (K‐115), over 24 hr in patients with primary open‐angle glaucoma POAG ) or ocular hypertension OHT ). Methods In this multicenter, prospective, randomized, open‐label, 3‐period, Latin‐square crossover clinical study, 28 whose level was 21 mmHg higher were subdivided into three groups. Each patient treated placebo and concentrations 0.2 0.4%, at 9:00 21:00 on day 1...
A paired homeodomain transcription factor, PAX6, is a well-known regulator of eye development, and its heterozygous mutations in humans cause congenital anomalies such as aniridia. Because it was recently shown that PAX6 also plays an indispensable role islet cell gene mutation may lead to defect the endocrine pancreas. Whereas islet-cell factors IPF1/IDX-1/STF-1/PDX-1 NEUROD1/BETA2 serve genetic diabetes or glucose intolerance, we investigated possibility being factor common aniridia...
Abstract Introduction Latanoprostene bunod (LBN) is a novel nitric oxide (NO)-donating prostaglandin F2α analog. We evaluated the long-term safety and intraocular pressure (IOP)-lowering efficacy of LBN ophthalmic solution 0.024% over 1 year in Japanese subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT). Methods This was single-arm, multicenter, open-label, clinical study. Subjects aged 20 years older diagnosis OAG OHT instilled drop affected eye(s) once daily evening for...
We studied the epithelial healing of denervated corneas in New Zealand albino rabbits with their left trigeminal ganglia surgically amputated. On 14th day after amputation, were keratectomized (in 8.5 mm diameter) and documentation process began. calculated rate using simple regression analysis. observed a mean 0.463 ± 0.059 mm2/hr (mean SE) corneas, compared to 0.609 0.031 control corneas; statistically significant difference P < 0.001. performed scanning electron microscopic observation...
Using immunohistochemical methods, substance P is localized to nerves of the human eye. Immunoreactive nerve fibers occur in cornea, about limbal blood vessels, and within trabecular meshwork. Substance P-like immunoreactive surround uveal especially choroid ciliary body. are seen processes. The muscle innervated, as iris dilator sphincter muscles. Apposition melanocytes apparent. distribution eye parallels that found other mammals. While probably has important neurotransmitter or...
To report the 5-year incidence of visual impairment after mitomycin C-augmented trabeculectomy (MMC trabeculectomy) and risk factors for impairment.This is a multicentre prospective observational cohort study. Among glaucoma patients registered in Collaborative Bleb-related Infection Incidence Treatment Study performed Japan, with eyes meeting following qualifications were included: primary open-angle glaucoma; angle-closure exfoliative ≥3/60 blindness analysis; ≥20/60 low-vision analysis...
Purpose: To present clinical features and microbial data for bleb-related infections obtained by the 5-year-long Japan Glaucoma Society Survey of Bleb-related Infection (JGSSBI). Methods: This multicentre prospective observational study was conducted in 82 centres Japan. A total 170 developed 157 eyes 156 patients during a 5-year period. The ophthalmological were analysed. Results: patient age at first infection 59.3 ± 17.7 years [mean standard deviation (SD)], period between last glaucoma...
Purpose: We assessed vision-related quality of life (VR-QOL) in glaucoma patients and examined the relationship between VR-QOL indices visual function subjective symptoms. Patients Methods: Four hundred seventy-two completed a questionnaire concerning symptoms glaucoma. was based on 5 subscales selected from National Eye Institute 25-item Visual Function Questionnaire (NEI VFQ-25), whereas were using original questions that we prepared. The following as indices: corrected acuity measured...
To evaluate the intraganglionic organization of ocular sensory neurons in guinea pig, we studied retrograde axonal transport from eye to trigeminal ganglion cholera toxin B subunit and then applied immunohistochemistry for substance P, calcitonin gene-related peptide cholecystokinin. Retrogradely labeled cells were observed only anteromedial portion ipsilateral ganglion. We no somatotopical containing any these three peptides, either projecting or as a whole. The relative proportion...
To estimate the incidence rate of endophthalmitis after cataract surgery performed by Japanese surgeons.A sample 20% members Society Ophthalmic Surgeons was randomly selected. Each member sent a postal survey asking for information on number surgeries in 2003 and postsurgery cases endophthalmitis.Replies were received from 78.7% (513/652) recipients. The total 100 539, among which 52 occurred, resulting an overall 0.052%. Incidence rates 0.049% (38/78 170) scleral incision...