A5027934896- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Corneal surgery and disorders
- Retinal and Macular Surgery
- Ophthalmology and Eye Disorders
- Proteoglycans and glycosaminoglycans research
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Cell Adhesion Molecules Research
- Retinal and Optic Conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ocular Surface and Contact Lens
- Retinal Imaging and Analysis
- Fibroblast Growth Factor Research
- Neurological Disorders and Treatments
- Ocular Infections and Treatments
- Connexins and lens biology
- Protein Kinase Regulation and GTPase Signaling
- Ocular Diseases and Behçet’s Syndrome
- Retinopathy of Prematurity Studies
- Neuroscience and Neuropharmacology Research
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
Kumamoto University
2014-2025
Kumamoto University Hospital
2012-2022
Kumamoto City Hospital
2003-2015
Collaborative Research Group
2002-2014
Ministry of Education, Culture, Sports, Science and Technology
2013
Kyoto University
1996-2012
Kurume University
2011
Yokohama City University
2009
Keio University
2008
Japan Science and Technology Agency
2008
To examine the diversity of cadherin family, we isolated cDNAs from brain and retina cDNA preparations with aid polymerase chain reaction. The products obtained included for two three known cadherins as well eight distinct cDNAs, which deduced amino acid sequences show significant similarity sequences. Larger clones were human libraries six new molecules. that overall structure these molecules is very similar to cadherins, indicating are members family. We have tentatively designated...
To elucidate the intraocular pressure (IOP)-lowering effects and associated characteristics of Y-39983, a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor derived from Y-27632, in animal eyes.Y-39983 was compared with Y-27632 for selectivity ROCK inhibition by biochemical assay. The IOP monitored pneumatonometer albino rabbits cynomolgus monkeys that were given topically administered Y-39983. total outflow facility uveoscleral measured two-level constant-pressure...
Objective: To investigate the effects and safety of topical administration an ophthalmic solution a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor, SNJ-1656, 0.003% to 0.1%, in healthy male adult volunteers.Design: Randomized, double-masked, group-comparison, phase 1 clinical study.In initial singleinstillation trial, 45 volunteers were randomly subdivided into 5 groups treated with SNJ-1656 concentrations 0.003%, 0.01%, 0.03%, 0.05%, 0.1% stepwise fashion.In...
Significance The lack of intravital imaging axonal transport mitochondria in the living mammalian CNS precludes characterization dynamics diseased and aged CNS. Here we report minimally invasive multiphoton mouse retinal ganglion cells that offers sequential time-lapse images transported a single axon with submicrometer resolution. We show highly dynamic vivo under physiological conditions characterize disturbances mitochondrial glaucoma model age-related changes transport. Our method is...
Aberrant epithelial-mesenchymal transition (EMT) is involved in development of fibrotic disorders and cancer invasion. Alterations cell-extracellular matrix interaction also contribute to those pathological conditions. However, the functional interplay between EMT interactions remains poorly understood. We now show that inflammatory mediator tumor necrosis factor-α (TNF-α) induces formation foci by cultured retinal pigment epithelial cells through activation transforming growth factor-β...
Abstract Ripasudil hydrochloride hydrate (K-115), a specific Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor, was the first ophthalmic solution developed for treatment of glaucoma and ocular hypertension in Japan. Topical administration K-115 decreased intraocular pressure (IOP) increased outflow facility rabbits. This study evaluated effect on monkey trabecular meshwork (TM) cells Schlemm’s canal endothelial (SCE) cells. induced retraction rounding cell bodies as well...
Abstract Purpose To investigate the intra‐ocular pressure ( IOP )‐lowering effects and safety of 0.4% ripasudil (K‐115), a Rho kinase inhibitor, twice daily for 52 weeks, in patients with open‐angle glaucoma or ocular hypertension OHT ). Methods In this multicentre, prospective, open‐label study, 388 primary glaucoma, exfoliation were enrolled 354 them subdivided into four cohorts (monotherapy, 173; additive therapy to prostaglandin analogs, 62; β ‐blockers, 60; fixed combination drugs, 59)....
We conducted a series of phase 1 clinical trials to elucidate the efficacy and safety selective Rho kinase inhibitor K-115 as candidate drug for treatment glaucoma. report intraocular pressure (IOP)-lowering effects based on our results.To study IOP-lowering topical administration inhibitor, K-115, in healthy male adult volunteers.Randomized, placebo-controlled, double-masked, group comparison trial.In initial single-instillation trial, 50 volunteers were subdivided into groups treated with...
Ripasudil hydrochloride hydrate (K-115), a novel rho kinase inhibitor, provides statistically significant intraocular pressure (IOP)-lowering effects and has tolerable safety profile. However, no studies have evaluated ripasudil combined with β-blockers prostaglandin analogues.To evaluate the additive IOP-lowering of ripasudil, 0.4%, timolol, 0.5%, or latanoprost, 0.005%, in patients primary open-angle glaucoma ocular hypertension.We conducted 2, multicenter, randomized, double-masked,...
To elucidate the long-term outcomes and prognostic factors for trabeculectomy with mitomycin C (MMC) in eyes uveitic glaucoma (UG).A retrospective, consecutive, comparative cohort study was conducted 204 patients who underwent MMC between 1999 2008 at 2 Japanese clinical centers. The group included 101 UG 103 primary open-angle (POAG). Surgical failure defined as intraocular pressure levels of ≥21 mm Hg or an additional surgery. Kaplan-Meier survival curves surgical were compared POAG eyes,...
Abstract Purpose To investigate the intra‐ocular pressure ( IOP )‐lowering effects of a selective Rho kinase inhibitor, ripasudil (K‐115), over 24 hr in patients with primary open‐angle glaucoma POAG ) or ocular hypertension OHT ). Methods In this multicenter, prospective, randomized, open‐label, 3‐period, Latin‐square crossover clinical study, 28 whose level was 21 mmHg higher were subdivided into three groups. Each patient treated placebo and concentrations 0.2 0.4%, at 9:00 21:00 on day 1...
Highlights•Two mouse models of immunodeficient end-stage retinal degeneration were established•Immunodeficient host permitted transplantation human ESC-derived sheets•Transplanted sheets survived long term and maturated•After transplantation, light responses recorded from the degenerated retinaSummaryIncreasing demand for clinical therapies featuring ESC/iPSC-derived tissue cells warrants proof-of-concept studies. Here, we established two with immunodeficiency, NOG-rd1-2J NOG-rd10,...
The optic nerve head in severely myopic eyes may be particularly vulnerable to glaucomatous damage. To study this hypothesis, we examined 122 primary open-angle glaucoma with fair good control of the intraocular pressure and a sign baseline Then, parameters for progression visual field defects were evaluated by multivariate analysis. A high mean (p = 0.007) large refractive error 0.023) significant risk factors subsequent loss. cup-to-disk ratio 0.100) was marginal factor. Nonsignificant...
Retrospective and prospective studies examined the surgical effects in lowering intraocular pressure levels of trabeculotomy ab externo adult eyes with either primary open angle glaucoma or pseudoexfoliation syndrome. We report results as an intervention for glaucoma.Included retrospective study were 357 227 patients 82 65 syndrome, each which underwent alone none had a history laser treatment ocular disease. Included 33 22 17 15 (older than 40 years) syndrome.A life-table analysis showed...