A5091809447- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Ophthalmology and Eye Disorders
- Retinal and Macular Surgery
- Proteoglycans and glycosaminoglycans research
- Retinal Development and Disorders
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- Connexins and lens biology
- Ocular Diseases and Behçet’s Syndrome
- Axon Guidance and Neuronal Signaling
- Corneal Surgery and Treatments
- Mitochondrial Function and Pathology
- Ocular Infections and Treatments
- Neuroscience and Neuropharmacology Research
- Glycosylation and Glycoproteins Research
- Hippo pathway signaling and YAP/TAZ
- Retinopathy of Prematurity Studies
- Aldose Reductase and Taurine
- Ocular Disorders and Treatments
- Fibroblast Growth Factor Research
- Cerebral Venous Sinus Thrombosis
University of Fukui
2016-2025
Kumamoto University
2009-2023
University of Fukui Hospital
2018-2022
YKK (Japan)
2016
Kyoto University
1997-2014
Kumamoto University Hospital
2012
Kurume University
2011
Sanford Burnham Prebys Medical Discovery Institute
2003-2010
Yokohama City University
2009
Discovery Institute
2007
Heparan sulfate (HS) is required for morphogen signaling during Drosophila pattern formation, but little known about its physiological importance in mammalian development. To define the developmental role of HS species, we conditionally disrupted HS-polymerizing enzyme EXT1 embryonic mouse brain. The EXT1-null brain exhibited patterning defects that are composites those caused by mutations multiple HS-binding morphogens. Furthermore, displayed severe guidance errors major commissural tracts,...
Objectives: This study evaluated the clinical preferences of glaucoma specialists regarding surgery and postoperative management in Japan 2024. Methods: A survey about practice care was administered among 50 who were councilors Glaucoma Society. Results: Minimally invasive (MIGS) plus phacoemulsification most preferred procedure for nonoperated mild to moderate cases primary open-angle (POAG) (94.6%) normal tension (NTG) (67.3%) associated with cataract. Microhook MIGS procedures. Meanwhile,...
Mutant mice bearing a targeted disruption of the heparan sulfate (HS) modifying enzyme GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) exhibit severe developmental defects forebrain and forebrain-derived structures, including cerebral hypoplasia, lack olfactory bulbs, eye axon guidance errors. Neural crest-derived facial structures are also severely affected. We show that properly synthesized is required for normal development brain face, Ndst1 modifier sulfate-dependent growth...
To elucidate the intraocular pressure (IOP)-lowering effects and associated characteristics of Y-39983, a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor derived from Y-27632, in animal eyes.Y-39983 was compared with Y-27632 for selectivity ROCK inhibition by biochemical assay. The IOP monitored pneumatonometer albino rabbits cynomolgus monkeys that were given topically administered Y-39983. total outflow facility uveoscleral measured two-level constant-pressure...
Objective: To investigate the effects and safety of topical administration an ophthalmic solution a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor, SNJ-1656, 0.003% to 0.1%, in healthy male adult volunteers.Design: Randomized, double-masked, group-comparison, phase 1 clinical study.In initial singleinstillation trial, 45 volunteers were randomly subdivided into 5 groups treated with SNJ-1656 concentrations 0.003%, 0.01%, 0.03%, 0.05%, 0.1% stepwise fashion.In...
Significance The lack of intravital imaging axonal transport mitochondria in the living mammalian CNS precludes characterization dynamics diseased and aged CNS. Here we report minimally invasive multiphoton mouse retinal ganglion cells that offers sequential time-lapse images transported a single axon with submicrometer resolution. We show highly dynamic vivo under physiological conditions characterize disturbances mitochondrial glaucoma model age-related changes transport. Our method is...
To elucidate the long-term outcomes and prognostic factors for trabeculectomy with mitomycin C (MMC) in eyes uveitic glaucoma (UG).A retrospective, consecutive, comparative cohort study was conducted 204 patients who underwent MMC between 1999 2008 at 2 Japanese clinical centers. The group included 101 UG 103 primary open-angle (POAG). Surgical failure defined as intraocular pressure levels of ≥21 mm Hg or an additional surgery. Kaplan-Meier survival curves surgical were compared POAG eyes,...
This multicenter retrospective study compared the surgical outcomes of Baerveldt glaucoma implant (BGI) surgery with those Ahmed valve (AGV) in patients neovascular (NVG). The included NVG aged ≥ 20 years who had undergone BGI (223 eyes) or AGV (146 between April 1, 2012 and December 31, 2021 across 10 clinical centers Japan. Surgical success failure was primary outcome measure this study. We defined as a reduction < 20% pre-operative intraocular pressure (IOP) criterion A (IOP > 21 mmHg), B...
purpose. Toll-like receptor 4 (TLR4) is a transmembrane that mediates immune responses to exogenous and endogenous ligands interacts with heat shock proteins, which are reportedly involved in normal tension glaucoma (NTG). This study was undertaken investigate whether TLR4 polymorphisms associated NTG. methods. Two hundred fifty Japanese patients NTG 318 healthy control subjects were recruited. Eight single-nucleotide (SNPs) the gene genotyped, allelic phenotypic diversity assessed between...
To evaluate cytokine and growth factor levels in the aqueous humor patients with open-angle glaucoma (OAG).Kumamoto University Hospital, Kumamoto, Japan.Cross-sectional cohort study.Aqueous samples were collected from cataract cases OAG cases. Aqueous of cytokines factors determined by multiplex immunoassay. The data analyzed using Tukey-Kramer honestly-significant-difference test multiple regression analyses.The study evaluated 52 73 In cases, mean interleukin (IL)-6, IL-8, monocyte...
Purpose.: To investigate the effect of a specific inhibitor Rho-associated protein kinase, Y-27632, on monkey Schlemm's canal endothelial (SCE) cells. Methods.: SCE cells were isolated from cynomolgus eyes. The effects Y-27632 aqueous outflow facility evaluated using enucleated eyes and constant-pressure perfusion system. barrier function confluent SCE-cell monolayer was by measuring transendothelial electrical resistance (TEER) fluorescein permeability. Y-27632–induced changes in...
To elucidate the impact of phacoemulsification on aqueous monocyte chemoattractant protein-1 (MCP-1) levels, and identify its cell origin.For clinical study, humor samples were collected before after surgery (17.0 ± 4.0 months postoperatively) from 21 cataract cases that underwent intraocular lens (IOL) implantation. Aqueous MCP-1 levels determined using a multiplex immunoassay. For animal experiments, rabbits (± IOL). nonoperated eyes operated eyes, immunoassays performed. Eyes analyzed by...
Mutations in optineurin (OPTN) are linked to the pathology of primary open angle glaucoma (POAG) and amyotrophic lateral sclerosis. Emerging evidence indicates that OPTN mutation is involved accumulation damaged mitochondria defective mitophagy. Nevertheless, role played by an E50K pathogenic mitochondrial mechanism underlies retinal ganglion cell (RGC) degeneration POAG remains unknown. We show here expression induces fission-mediated degradation mitophagy axons glial lamina aged E50K-tg...
There is increasing evidence that heparan sulfate (HS) plays an essential role in various axon guidance processes. These observations, however, have not addressed whether HS required cell autonomously as axonal coreceptor or environmental factor modulates the localization of molecules terrain which growing axons navigate. Here we demonstrate netrin-1-mediated commissural requires cell-autonomous expression neurons vivo . We used Wnt1 –Cre transgene to drive region-specific ablation Ext1 ,...
To evaluate the effects of intravitreal bevacizumab (IVB) before mitomycin C trabeculectomy (MMCT) for neovascular glaucoma (NVG).The study is a retrospective, comparative, consecutive case series. The group consisted 57 eyes from 50 patients with NVG who underwent first MMCT: 33 were treated MMCT alone between June 1, 2005 and May 17, 2007 (Control Group); and, 24 combination IVB after 18, (IVB Group). Surgical complications, intraocular pressure (IOP), probability success compared 2...
To investigate the rate and risk factors for neovascular glaucoma (NVG) after vitrectomy in proliferative diabetic retinopathy (PDR).Five hundred twelve patients (512 eyes) with PDR who underwent between January 1, 2003 June 30, 2009 at Kumamoto University Hospital, Japan, were retrospectively evaluated. Postoperative NVG was defined as neovascularization anterior segment intraocular pressure (IOP) ≥ 22 mm Hg vitrectomy. Kaplan-Meier survival analysis applied to calculate of Risk identified...